Results 41 to 50 of about 705,010 (250)

Enhancing professionalism - progressing the career development sector [PDF]

, 2015
Much has changed in the career development sector since the launch of the Careers Profession Task Force report, ‘Towards a Strong Careers Profession’ in 2010.
Neary, Siobhan, Neary, S., Johnson, Claire   +2 more
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Pathways to leadership: what accounts for women’s (in)equitable career paths in the health sectors in India and Kenya? A scoping review

BMJ Global Health
Objectives We aimed to capture evidence on enablers and barriers to improving equal opportunity and effective organisational interventions that can advance women’s leadership in India and Kenya’s health sectors.Methods We systematically searched JSTOR ...
Sarah Hawkes, Kent Buse, Sonja Tanaka, Ravi Verma, Naomi M Saville, Sylvia Kiwuwa-Muyingo, Henry Owoko Odero, Aaron Koay, Sapna Kedia, Radhika Uppal, Sally Atieno Odunga, Lawrence Eleh, Sucharitha Venkatesh, Zahra Zeinali   +13 more
doaj   +1 more source

Barriers to learning and using point-of-care ultrasound: a survey of practicing internists in six North American institutions

The Ultrasound Journal, 2020
Background Point-of-care ultrasound (POCUS) is increasingly used in internal medicine, but a lack of trained faculty continues to limit the spread of POCUS education.
Jonathan Wong, Steven Montague, Paul Wallace, Kay Negishi, Andrew Liteplo, Jennifer Ringrose, Renee Dversdal, Brian Buchanan, Janeve Desy, Irene W. Y. Ma   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Career decision-making in impoverished contexts: Why do rural youth find it hard or easy to make a career choice?

African Journal of Career Development
Background: In the ever-changing economic landscape characterised by job scarcities and high rates of unemployment, making a sensible career choice has become increasingly crucial in helping individuals find their career paths.
Bongani Mtshweni, Asanda Nogqala, Anza Ndou, Kagiso D. Mahlatji, Mpho Mathane, Nature M. Masufi, Zuzeka P. Mkra   +6 more
doaj   +1 more source

‘They Can Replace You at Any Time!’: (In)Visible Hyper-Ableism, Employment and Sickle Cell Disorders in England

Scandinavian Journal of Disability Research, 2021
This paper explores how ableism interacts with multiple identities in the workplace, in order to understand barriers and enablers to employment. Two focus group discussions and forty-seven semi-structured interviews were conducted with people who have ...
Maria Berghs, Simon Dyson, Anne-Marie Greene, Karl Atkin, Vanetta Morrison   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source