Results 51 to 60 of about 705,010 (250)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
career service papers - csp 17/19
, 2019 Themen dieser Ausgabe sind veränderte Anforderungen an Hochschule und Arbeitgeber*innen (Generation Z), Beiträge zu studentischen Praktika und zur Qualitätssicherung von Praktika, ein Beitrag zur Beschäftigungsfähigkeit und Qualitätssicherung im Rahmen ...
Dorenburg, Christiane +9 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
SAGE OpenInclusive entrepreneurship has increasingly received attention as a promising means of simultaneously fostering economic growth and mitigating inequality.
Aaron A. Vargas-Zeledon, Su-Yol Lee
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
The Fifth National Career Leaders Conference [PDF]
, 2022 This article reflects on the recent Career Leaders Conference held at the University of Derby in June 2022. The report explains the importance of the event and the role that the University plays in supporting the career development ...
Moore, N.
core
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Supporting Transition to the Workforce for Neurodivergent Learners
GiLE Journal of Skills DevelopmentThis article offers evidence-based recommendations to enhance the neuroinclusivity of post-secondary career education and practices for career educators and student support professionals.
Jennifer Fane, Liana Giacoboni
doaj +1 more source