Results 51 to 60 of about 50,485 (292)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Perceived social support as predictors of adolescents’ career exploration

, 2014
The aim of this study was to examine whether adolescents’ career exploration is predicted by perceived social support. Participants were 718 seventh, eighth, ninth and tenth grade students.
Çelik, E., Turan, M. E., Turan, E.
core   +1 more source

FAKTOR YANG MEMENGARUHI EKSPLORASI KARIER SISWA SLTP

Cakrawala Pendidikan: Jurnal Ilmiah Pendidikan, 2013
Abstrak: Faktor yang Mempengaruhi Eksplorasi Karier Siswa SLTP. Penelitian ini bertujuan untuk mengungkap pengaruh kepribadian siswa terhadap eksplorasi karier, pengaruh prestasi akademik, dan persepsi aspirasi orang tua terhadap perilaku eksplorasi ...
Edi Purwanta
doaj   +1 more source

Career Exploration as Social and Emotional Learning: A Collaborative Ethnography with Spanish Children from Low-Income Contexts

Education Sciences, 2021
Children’s career exploration is a critical aspect of career development. Through it, children explore the interplay between their different life roles, including those related to work (in a broad sense), learning, and education.
Soledad Romero-Rodríguez, Celia Moreno-Morilla, David Muñoz-Villaraviz, Marina Resurrección-Pérez   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Helicopter parenting during emerging adulthood: Consequences for career identity and adaptability

Frontiers in Psychology, 2022
This study explores the relationship between parental over involvement and the career development of emerging adults. Specifically, it investigates how emerging adults’ career meta competencies of vocational identity formation and career adaptability ...
Joshua E. LeBlanc, Sean T. Lyons
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source