Results 71 to 80 of about 1,993,068 (279)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Career Decision-Making Difficulties: Why Exploration Alone Is Not Enough for High School Students

Gadjah Mada Journal of Professional Psychology
Career exploration is important for high school students to face career decision-making difficulties. This study aims to investigate the effect of career exploration training on career decision-making difficulties among 12th-grade high school students. A
Janice Grace Lusiani Larasati Simanjuntak
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dinamika Eksplorasi Karier Mahasiswa: Peran Dukungan Sosial Orang Tua dan Status Sosial Ekonomi

Jurnal Humanitas: Katalisator Perubahan dan Inovator Pendidikan
University students are in the emerging adulthood phase, characterized by increasing demands to prepare for careers and determine future directions.
Dini Rahma Lestari, Talitha Lintang Pertiwi   +1 more
doaj   +1 more source

Enhancing professionalism - progressing the career development sector [PDF]

, 2015
Much has changed in the career development sector since the launch of the Careers Profession Task Force report, ‘Towards a Strong Careers Profession’ in 2010.
Neary, Siobhan, Neary, S., Johnson, Claire   +2 more
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Examining Career Calling Through Career Exploration: The Influence of Decision Self-Efficacy and Openness

Social Sciences
In today’s rapidly changing social and employment environment, young university students face unprecedented career development challenges. They must not only acquire strong professional knowledge and skills but also navigate the complex job market ...
Xiaomin Su, Anuar Ahmad, Jamsari Alias
doaj   +1 more source

Kontribusi Planned Happenstance Skills terhadap Perilaku Eksplorasi Karier Siswa Sekolah Menengah Kejuruan: Peran Mediasi Career Decision Self-Efficacy

Jurnal Kajian Bimbingan dan Konseling, 2020
: Career exploration is the acquisition of career information that results in the formation of career maturity. This study aims to explain the role of internal factors that drive career exploration behavior.
Subhanallah Ramdhan, Rose Mini Agoes Salim   +1 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source