Results 71 to 80 of about 609,358 (298)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

School is over - what to do? How school prepares for the transition from school to apprenticeship or university as perceived by 11th graders [PDF]

, 2006
Die Schule hat den ausdrücklichen Auftrag Jugendliche im Prozess der Berufswahl zu unterstützen. Geeignete schulische Maßnahmen sollen Jugendlichen ermöglichen, gut überlegte Entscheidungen für ein Studium oder eine Ausbildung zu treffen. Die vorliegende
Kracke, Bärbel
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Career Decision-Making Difficulties: Why Exploration Alone Is Not Enough for High School Students

Gadjah Mada Journal of Professional Psychology
Career exploration is important for high school students to face career decision-making difficulties. This study aims to investigate the effect of career exploration training on career decision-making difficulties among 12th-grade high school students. A
Janice Grace Lusiani Larasati Simanjuntak
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Enriching Summer Work: An Evaluation of the Summer Career Exploration Program [PDF]

, 2004
To determine the impact of the Summer Career Exploration Program (SCEP), a privately funded summer jobs program for low-income teens, P/PV examined the lives of over 1700 applicants. These youth were randomly assigned to participate or to not participate
Cynthia L. Sipe, Thomas J. Smith, Wendy S. McClanahan   +2 more
core  

The Philosophical Significance of Wittgenstein’s Experiments on Rhythm, Cambridge 1912–13 [PDF]

, 2020
Wittgenstein’s experiments on rhythm, conducted in Charles Myers’s laboratory in Cambridge during the years 1912–13, are his earliest recorded engagement in thinking about music, not just appreciating it, and philosophizing by means of musical thinking ...
Guter, Eran
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Examining Career Calling Through Career Exploration: The Influence of Decision Self-Efficacy and Openness

Social Sciences
In today’s rapidly changing social and employment environment, young university students face unprecedented career development challenges. They must not only acquire strong professional knowledge and skills but also navigate the complex job market ...
Xiaomin Su, Anuar Ahmad, Jamsari Alias
doaj   +1 more source

Pathways from caring and engaging adults to youth vocational identity: the mediational roles of career search self-efficacy and goal capacity [PDF]

, 2017
This study examines the role played by access to caring and engaging adults, career search self-efficacy (CSSE), and goal capacity in the development of youth vocational identity.
Chen, Zi, Solberg, V. Scott H.
core   +1 more source