Results 71 to 80 of about 50,485 (292)

Career Decision-Making Difficulties: Why Exploration Alone Is Not Enough for High School Students

Gadjah Mada Journal of Professional Psychology
Career exploration is important for high school students to face career decision-making difficulties. This study aims to investigate the effect of career exploration training on career decision-making difficulties among 12th-grade high school students. A
Janice Grace Lusiani Larasati Simanjuntak
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Gender Differences for Optimism, Self-esteem, Expectations and Goals in Predicting Career Planning and Exploration in Adolescents

, 2004
An Australian sample (N = 467) of high school students was administered scales tapping optimism, self-esteem, career expectations, career goals, career planning and career exploration. The study tested a career mediational model based on social cognitive
Bartrum, Dee, Patton, Wendy A., Bartrum, Dee A., Creed, Peter A, Creed, Peter, Patton, Wendy   +5 more
core   +1 more source

Examining Career Calling Through Career Exploration: The Influence of Decision Self-Efficacy and Openness

Social Sciences
In today’s rapidly changing social and employment environment, young university students face unprecedented career development challenges. They must not only acquire strong professional knowledge and skills but also navigate the complex job market ...
Xiaomin Su, Anuar Ahmad, Jamsari Alias
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The Role of Career Exploration Behavior as A Mediator in The Relationship Between Social Support and Career Decision Self-Efficacy Among High School Students

Jurnal Kependidikan
This study aims to analyze the role of career exploration behavior as a mediator of the relationship between social support and career decision self-efficacy (CDSE) among high school students.
Atika Rahmania El Barusi, Puji Lestari Suharso   +1 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Qualitative exploration of career adaptability of Turkish adolescents

, 2019
This article reports on a qualitative study that uses a phenomenological approach to investigate the differences between adolescents with high and low career adaptability levels, regarding adaptive strategies and needs.
KARACAN ÖZDEMİR, NURTEN, Ozdemir, Nurten Karacan   +1 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Career development learning in higher education: how authentic work experiences and opportunities for career exploration canincrease self-efficacy and inform career identity

, 2015
A recent study suggests that enhancing career development is a key motivator for students entering university (Kandiko & Mawer, 2013). This article discusses the place of career development learning within the ‘employability’ agenda.
Benton, Paula
core