Results 81 to 90 of about 50,485 (292)

Between- and within-person level motivational precursors associated with career exploration

, 2016
Career exploration is a critical process for child and adolescent development leading people toward suitable work and developing a vocational identity.
Lee, Bora, Porfeli, Erik J., Hirschi, Andreas   +2 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Effect of career exploration program on career maturity and self-concept among Form Four students / Lau Poh Li

, 2011
This study investigated the effect of the Career Exploration Program (CEP) on career maturity and self-concept of Form Four subjects (N = 139) in a typical secondary school as assessed by the Career Maturity Inventory Revised (CMI-R) and Tennessee Self ...
Lau, Poh Li
core  

The Effect of Evaluation on Career Support by the College and Career Exploration Efficacy of Dental Hygiene Students on the Career Exploration Behavior

Journal of dental hygiene science, 2015
efficacy, and career exploration behavior.
Eun-Suk Jeon, Eun-Mi Noh, Hyo-Jin Ko
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Protean and Boundaryless Career Attitudes in New Zealand Workers

, 2010
This study explored protean and boundaryless career attitudes in a sample of New Zealand workers. Recent changes to both organisational and societal structures have significantly altered how careers are acted out.
Morrell, Heather Rebecca
core  

Career exploration and its influence on the relationship between self-efficacy and career choice: The moderating role of social support

Heliyon
Career choice is a highly complex process. The growth in the number, nature, and overlap between occupations creates a more multifaceted career landscape, especially for young people.
Minh Pham, Bao Quoc Lam, Anh Tuan Ngoc Bui   +2 more
doaj   +1 more source

Career Exploration and Career Decision-Making Difficulties

Journal of Career Assessment, 2017
This article investigated the moderating role of creative self-efficacy (CSE) on the relationship between career exploration and career decision-making difficulties among French undergraduate students ( N = 415). Drawing a parallel between the career decision-making process and the notion of creative problem-solving, we reasoned that career exploration
Storme, Martin, Celik, Pinar
openaire   +2 more sources