Results 71 to 80 of about 672,324 (310)

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Psychological intervention in Portuguese college students: effects of two career self-management seminars [PDF]

, 2015
This article describes the evaluation of a psychological intervention—the Career Self-Management Seminar, Version A, for undergraduate students, and Version B for postgraduate students—developed to support Portuguese college students in career ...
Loureiro, Nazaré, Pinto, Joana Carneiro, Taveira, Maria do Céu   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Interdisciplinary educational intervention to career groups

INFAD, 2019
Background: The quality of life of caregivers is conditioned by several factors: the context of the caregiver, the degree of dependency of the family member, the type of illness, the mediating elements (formal administration and informal support, family ...
Carmen García López, José Carrascal Gutiérrez, Diego Pérez Vázquez   +2 more
doaj   +1 more source

Career self-management and vocational guidance: theory, practice and empirical contributions [PDF]

, 2010
En este artículo se aborda y discute el concepto de gestión personal de la carrera y su importancia en términos de empleabilidad profesional en la vida adulta.
Rodríguez-Moreno, Maria Luísa, Taveira, Maria do Céu   +1 more
core  

Effects of a vocational psychological intervention on career adaptability [PDF]

, 2017
A intervenção psicológica vocacional deve proporcionar oportunidades para o desenvolvimento de conhecimentos e competências vocacionais, permitindo aos alunos, a implementação de decisões esclarecidas de carreira.
Cordeiro, Sílvia Amado, Lobo, Cristina Costa, Neves, Lúcia, Rodrigues, Bruna, Silva, Ana Daniela, Taveira, Maria do Céu   +5 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Assessment of the value of group-based counselling for career construction

International Journal of Adolescence and Youth, 2018
This article reports on the change in the career adaptability of participants exposed to an intervention programme characterized by career and self-construction principles compared to the change in participants who participated in standard, traditional ...
Jacobus Gideon Maree, Antoinette V. Cook, Lizelle Fletcher   +2 more
doaj   +1 more source

Pathways from caring and engaging adults to youth vocational identity: the mediational roles of career search self-efficacy and goal capacity [PDF]

, 2017
This study examines the role played by access to caring and engaging adults, career search self-efficacy (CSSE), and goal capacity in the development of youth vocational identity.
Chen, Zi, Solberg, V. Scott H.
core   +1 more source