Results 31 to 40 of about 3,371 (214)

Precision medicine for suicidality: from universality to subtypes and personalization [PDF]

, 2017
Suicide remains a clear, present and increasing public health problem, despite being a potentially preventable tragedy. Its incidence is particularly high in people with overt or un(der)diagnosed psychiatric disorders.
Ballew, A, Dainton, H L, Gelbart, T, Graham, D L, Jones, T J, Kurian, S M, Le-Niculescu, H, Levey, D F, Niculescu, A B, Niculescu, E M, Niezer, J O, Phalen, P L, Roseberry, K, Salomon, D R, Sandusky, G E, Schork, N J, Shekhar, A, Venugopal, V, Williams, A, Yard, M   +19 more
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Case report : Successful administration of cariprazine in a young, severely ill patient with recurrent relapses of schizophrenia and persistent negative symptoms [PDF]

, 2023
Publisher Copyright: Copyright © 2023 Vrublevska.The present case report describes a young man diagnosed with schizophrenia and presents a “revolving door” (RD) phenomenon. He was hospitalized in an acute psychiatric clinic three times in 1 year.
Vrublevska, Jelena
core   +1 more source

Relationship Between Plasma Concentrations and Clinical Effects of Cariprazine in Patients With Schizophrenia or Bipolar Mania

Clinical and Translational Science, 2020
Population pharmacokinetic/pharmacodynamic modeling (via NONMEM) was used to describe longitudinal exposure‐response relationships for total cariprazine (sum of cariprazine and its major active metabolites) in 2,558 patients with schizophrenia or bipolar
Antonia Periclou, Susan Willavize, David Jaworowicz, Julie Passarell, Timothy Carrothers, Parviz Ghahramani, Suresh Durgam, Willie Earley, Margit Kapás, Tatiana Khariton   +9 more
doaj   +1 more source

Case series: Cariprazine in early-onset schizophrenia

Frontiers in Psychiatry, 2023
IntroductionNegative symptoms are part of the clinical manifestations of schizophrenia and their presence is associated with a poorer prognosis, significantly limited vocational opportunities, impaired quality of life and social functioning.
Elena Ivanova, Elena Ivanova, Desislava Maslinkova, Desislava Maslinkova, Nadia Polnareva, Vihra Milanova   +5 more
doaj   +1 more source

Early Clinical Effects of Novel Partial D3/D2 Agonist Cariprazine in Schizophrenia Patients With Predominantly Negative Symptoms (Open-Label, Non-controlled Study)

Frontiers in Psychiatry, 2022
BackgroundBecause of limited efficacy of antipsychotics against negative symptoms in schizophrenia new drugs with wider spectrums of clinical efficacy are very desirable.
Stanislav V. Ivanov, Stanislav V. Ivanov, Anatoly B. Smulevich, Anatoly B. Smulevich, Evgeniya I. Voronova, Evgeniya I. Voronova, Kausar K. Yakhin, Tangyul Z. Beybalaeva, Alena A. Katok   +8 more
doaj   +1 more source

Dopamine dysregulation in the prefrontal cortex relates to cognitive deficits in the sub-chronic PCP-model for schizophrenia: a preliminary investigation [PDF]

, 2017
yesRationale: Dopamine dysregulation in the prefrontal cortex (PFC) plays an important role in cognitive dysfunction in schizophrenia. Sub-chronic phencyclidine (scPCP) treatment produces cognitive impairments in rodents and is a thoroughly validated ...
Andrew MJ Young, Joanna C Neill, Michael K Harte, Paxinos G, Samantha L McLean, Snigdha S, Yee BK   +6 more
core   +2 more sources

The effect of cariprazine on patient engagement: Post-hoc analysis of a phase 3 study in patients with predominant negative symptoms of schizophrenia

European Psychiatry, 2021
Introduction Motivation deficit is a significant aspect of lack of improvement in patients with schizophrenia especially with predominant negative symptoms (PNS).
I. Laszlovszky, Z.B. Dombi, Á. Balogh, Á. Barabássy, G. Vass, B. Szatmári, G. Németh   +6 more
doaj   +1 more source

The efficacy of cariprazine in chronic schizophrenia – post hoc analyses of phase II/III clinical trials

European Psychiatry, 2022
Introduction Chronic schizophrenia patients are experiencing persistent and severe illness for more than 15-20 years and are usually suffering from long-term negative symptoms.
P. Falkai, Z. Dombi, K. Acsai, Á. Barabássy, G. Németh   +4 more
doaj   +1 more source

Multiple Fragment Docking and Linking in Primary and Secondary Pockets of Dopamine Receptors [PDF]

, 2014
A sequential docking methodology was applied to computationally predict starting points for fragment linking using the human dopamine D-3 receptor crystal structure and a human dopamine D-2 receptor homology model.
Horti, Ferenc, Keserű, György Miklós, Vass, Márton, Ágai-Csongor, Éva   +3 more
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Evaluation of cariprazine in the treatment of bipolar I and II depression: a randomized, double-blind, placebo-controlled, phase 2 trial [PDF]

, 2021
This double-blind placebo-controlled, fixed/flexible-dose phase 2 trial assessed the efficacy, safety, and tolerability of cariprazine vs. placebo for depressive episodes associated with bipolar I or II disorder. Primary endpoint was change in Montgomery-
Earley, Willie, Vieta i Pascual, Eduard, 1963-, Yatham, Lakshmi N.ª.   +2 more
core   +1 more source