Results 81 to 90 of about 3,371 (214)

Early-Onset Schizophrenia With Predominantly Negative Symptoms: A Case Study of a Drug-Naive Female Patient Treated With Cariprazine [PDF]

, 2020
Schizophrenia is a chronic and severe mental disorder characterized by positive, negative, and cognitive symptoms. Negative symptoms are usually present from the prodromal phase; early diagnosis and management of negative symptoms is a major health ...
Arango, Bartlet, Boonstra, Clemmensen, Correll, Fusar-Poli, Galderisi, Gauthier, Groth-Marnat, Hafner, Hsiao, Hsieh, Immonen, Kao, Kirkpatrick, Klosterkotter, Krause, Lehman, Leucht, Leucht, Marder, McGuffin, Millan, Mucci, Murru, Nemeth, Olie, Penttila, Perkins, Rabinowitz, Riedel, Russell, Stahl, Stahl, Veerman   +34 more
core   +1 more source

Oral Adverse Effects of Antipsychotic Medications: A Case/Noncase Analysis of EudraVigilance Data

Oral Diseases, Volume 31, Issue 8, Page 2630-2640, August 2025.
ABSTRACT Objective Neuropsychiatric disorders are associated with poor oral health, with antipsychotics as potential contributors. This study aimed to analyse the oral adverse effects of antipsychotics using the EudraVigilance database. Methods A case/noncase analysis was conducted to calculate reporting odds ratios (ROR) and assess the ...
Leire Urien, Unax Lertxundi, Montserrat Garcia, Carmelo Aguirre, Nerea Jauregizar, Teresa Morera‐Herreras   +5 more
wiley   +1 more source

Mechanism of action of cariprazine [PDF]

CNS Spectrums, 2016
Cariprazine is a new therapeutic agent recently approved for the treatment of both schizophrenia and manic or mixed episodes associated with bipolar disorder, and is under investigation for the treatment of both bipolar depression and major depressive disorder.
openaire   +2 more sources

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, Volume 182, Issue 14, Page 3044-3067, July 2025.
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source

Differential G protein activation by the long and short isoforms of the dopamine D2 receptor

British Journal of Pharmacology, Volume 182, Issue 14, Page 3336-3352, July 2025.
Background and Purpose The dopamine D2 receptor is expressed as a short (D2S) and a long (D2L) isoform with 29 additional amino acids in the third intracellular loop. The D2S isoform shows higher presynaptic expression than the D2L isoform, and decreased D2S expression has recently been linked to an increased risk for schizophrenia.
David Reiner‐Link, Jakob Sture Madsen, David E. Gloriam, Hans Bräuner‐Osborne, Alexander S. Hauser   +4 more
wiley   +1 more source

The safety and tolerability of cariprazine in long-term treatment of schizophrenia: a post hoc pooled analysis

BMC Psychiatry, 2017
Background Schizophrenia is a chronic and debilitating neuropsychiatric disorder that often requires long-term pharmacotherapy to manage symptoms and prevent relapse.
Henry A. Nasrallah, Willie Earley, Andrew J. Cutler, Yao Wang, Kaifeng Lu, István Laszlovszky, György Németh, Suresh Durgam   +7 more
doaj   +1 more source

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, Volume 182, Issue 14, Page 3249-3300, July 2025.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

Impact of cariprazine on body weight and blood pressure among adults with bipolar I disorder, schizophrenia, or major depressive disorder in a real-world setting

Annals of General Psychiatry
Background Atypical antipsychotics are a common treatment for serious mental illness, but many are associated with adverse effects, including weight gain and cardiovascular issues, and real-world experience may differ from clinical trial data ...
Christoph U. Correll, Andrew J. Cutler, François Laliberté, Guillaume Germain, Sean D. MacKnight, Julien Boudreau, Sally W. Wade, Nadia Nabulsi, Huy-Binh Nguyen, Mousam Parikh   +9 more
doaj   +1 more source

Negative Symptoms of Schizophrenia: Constructs, Burden, and Management [PDF]

, 2018
The aim of the chapter is to raise awareness about recent constructs of negative symptoms, their burden on patients, caregivers and society, and about their management. Schizophrenia consists of positive, negative, and cognitive symptoms.
Barabassy, Agota, Laszlovszky, István, Németh, György, Szatmári, Balázs   +3 more
core   +1 more source

Anthropogenic reaction parameters - the missing link between chemical intuition and the available chemical space [PDF]

, 2014
How do skilled synthetic chemists develop such a good intuitive expertise ? Why can we only access such a small amount of the available chemical space — both in terms of the re actions used and the chemical scaffolds we make?
Anderson, Arcadi, Arndtsen, Athanasiadis, Baghbanzadeh, Bemis, Bemis, Blum, Bohacek, C. Oliver Kappe, Chebanov, Damm, DeSimone, Eckert, Edwards, Enders, Enders, Erős, Fedorov, Feigenbaum, Gartner, Gartner, Gibb, Grabowski, Graulich, Greaney, Grondal, Grueneberg, Gutmann, György M. Keserű, Hashmi, Hessel, Hessel, Inhelder, Kahneman, Kahneman, Kappe, Kappe, Klahr, Klein, Kolb, Kutchukian, Larsen, Ley, Li, Lipkus, Lovering, Malet-Sanz, Manktelow, McNally, Morley, Moses, Munos, O'Brien, Obermayer, Reichardt, Reymond, Ruddigkeit, Schummer, Simon, Simon, Simon, Soós, Stephan, Tibor Soós, Tietze, Tversky, Wang, Weisinger, Welch, Wiles, Yoon, Yoshida   +72 more
core   +1 more source