Results 81 to 90 of about 2,979 (199)

Social and Clinical Factors Associated With Antipsychotic Medication Discontinuation in Patients With Schizophrenia

International Journal of Methods in Psychiatric Research, Volume 35, Issue 2, June 2026.
ABSTRACT Objectives This study aims to identify social and clinical factors associated with antipsychotic medication discontinuation in patients with schizophrenia. Methods This cross‐sectional case‐control study comprised 111 schizophrenia patients, including 55 who discontinued medication on their own initiative and 56 matched continuous‐treatment ...
Zhengquan Chen, Yiming Wu, Zuowei Wang, Jun Wang, Chao Jiang, Wenchao Shen, Yanting Zheng, Yi Wu   +7 more
wiley   +1 more source

Effect of cariprazine on attention and quality of life in patients with predominant negative symptoms of schizophrenia: A post-hoc analysis

Schizophrenia Research: Cognition
Background: Cariprazine, a potent dopamine D3-preferring D3/D2 receptor partial agonist, has demonstrated benefits on negative symptoms among patients with schizophrenia.
Oloruntoba J. Oluboka, Andrea Bardell, Howard C. Margolese, Philip G. Tibbo, Lisa Buchy, Christine Di Cresce, Jun Yu, Roger S. McIntyre   +7 more
doaj   +1 more source

Pharmacological Management, Safety, and Outcomes in Bipolar Disorder: An Integrated Narrative Review of Clinical and Translational Evidence

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
This graph summarizes bipolar disorder management, showing pharmacological treatments including lithium, valproate, antipsychotics, combination therapy, and emerging agents. It links these treatments to outcomes such as relapse reduction, mortality benefits, and cognitive effects, while highlighting safety issues, poor adherence, pregnancy risks, and ...
Gudisa Bereda
wiley   +1 more source

Tailoring cariprazine for dual disorders via secondary pharmacophore optimization [PDF]

Cariprazine is an approved drug used to treat schizophrenia, bipolar disorder, and (more recently) major depression. These serious mental illnesses are often comorbid with psychostimulant use disorders, for which no pharmacotherapeutic is currently ...
Bonifazi, Alessandro, Ranjit, Arina, Rais, Rana, Lane, J. Robert, Vogt, Caleb D., Newman, Amy Hauck, Saab, Elizabeth, Sanchez, Julie   +7 more
core   +1 more source

Efficacy and safety of 2–4 mg brexpiprazole in the management of schizophrenia: A systematic review and meta‐analysis

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.
This graphical summary illustrates the efficacy and safety of brexpiprazole (2–4 mg) in patients with schizophrenia. The meta‐analysis demonstrates significant improvement in clinical outcomes, with reductions in Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression ‐ Severity scale (CGI‐S) scores, indicating better symptom ...
Sher Bano, Aashan Ahmad, Abdul Haseeb Mohammed, Ismailova Rushana Nurbekovna, Saja Saad, Noor Fatima, Muhammad Bilal Akbar, Zainab Salahuddin, Sadikun Nabi, Mohammad Mustafa Ababneh, Laiba Ajmal, Sidra Hariss, Hiba Manaf, Farah Saleh, Raouf Khan   +14 more
wiley   +1 more source

Cariprazine: a review in schizophrenia

, 2018
Compliance with Ethical StandardsFunding The preparation of this review was not supported by any external funding.Conflicts of interest Karly Garnock-Jones is a salaried employee of Adis/Springer, is responsible for the article content and declares no ...
Karly Garnock-Jones (4985351)
core   +1 more source

Efficacy and Tolerability of Cariprazine as Monotherapy for Acute Bipolar Depression: A Systematic Review and Meta-analysis

Journal of Psychiatry Spectrum
Background: Bipolar depression (BDep) presents a significant clinical challenge with limited treatment options. The second-generation antipsychotics are increasingly utilized as primary or adjunct treatments.
Poulami Laha, Rakshathi Basavaraju, Soumya Parameshwaran, Dinakaran Damodaran, Palash Kumar Malo, Binukumar Bhaskarapillai, Muralidharan Kesavan   +6 more
doaj   +1 more source

Clinical pharmacology consultations and their implementation in clinical decision making

British Journal of Clinical Pharmacology, Volume 92, Issue 4, Page 1069-1077, April 2026.
Aims One of the key roles of clinical pharmacologists is to work as consultants for other medical specialties. We wanted to investigate the characteristics of clinical pharmacology consultations, compare the types of consultations from different specialties, and evaluate how well the recommendations given were followed.
Mirjam Kauppila, Janne T. Backman, Outi Lapatto‐Reiniluoto   +2 more
wiley   +1 more source

A case series of serious and unexpected adverse drug reactions under treatment with cariprazine

, 2021
Reporting of new or unexpected adverse drug reactions of medicines that are subject to additional monitoring (“black triangle” label), such as the antipsychotic drug cariprazine, is of paramount importance to improve pharmacotherapy safety.Reporting of ...
Stefan Bleich, Bleich, Stefan, Gregor R. Szycik, Szycik, Gregor R., Adrian Groh, Detlef Degner, Seifert, Johanna, Toto, Sermin, Dirk O. Stichtenoth, Grohmann, Renate, Michael Schneider, Johannes Heck, Renate Grohmann, Catherine Glocker, Groh, Adrian, Sermin Toto, Johanna Seifert, Ivana Adamovic, Christoph Schroeder, Rüther, Eckart, Schneider, Michael, Glocker, Catherine, Eckart Rüther, Heck, Johannes, Degner, Detlef, Schroeder, Christoph, Adamovic, Ivana, Stichtenoth, Dirk O.   +27 more
core   +1 more source

Cariprazine in the management of negative symptoms of schizophrenia : state of the art and future perspectives [PDF]

, 2020
In schizophrenia, dopaminergic hyperactivity in the mesolimbic regions, or possibly even selectively so in the dorsal striatum, seems to cause the emergence of psychotic symptoms, whereas dopaminergic hypoactivity in cortical regions underlies the ...
Singh, Swaran P., Correll, Christoph U, Demyttenaere, Koen, Racagni, Giorgio, Hajak, Göran, Fagiolini, Andrea, Pallanti, Stefano, Singh, Swaran, Correll, Christoph U., Giorgio Racagni, Swaran Singh, Christoph U Correll, Göran Hajak, Koen Demyttenaere, Andrea Fagiolini, Stefano Pallanti   +15 more
core   +1 more source