Results 61 to 70 of about 2,693 (199)

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 345-356, August 2026.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, Volume 19, Issue 7, July 2026.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

Tailoring cariprazine for dual disorders via secondary pharmacophore optimization [PDF]

Cariprazine is an approved drug used to treat schizophrenia, bipolar disorder, and (more recently) major depression. These serious mental illnesses are often comorbid with psychostimulant use disorders, for which no pharmacotherapeutic is currently ...
Bonifazi, Alessandro, Ranjit, Arina, Rais, Rana, Lane, J. Robert, Vogt, Caleb D., Newman, Amy Hauck, Saab, Elizabeth, Sanchez, Julie   +7 more
core   +1 more source

Electrochemical Hofmann Rearrangement for Modular Synthesis of Unsymmetrical Ureas and Late‐Stage Modification of Drugs

Advanced Science, Volume 13, Issue 31, 4 June 2026.
An electrochemical Hofmann rearrangement of amide involving amine or other amide nucleophiles has been developed. The use of NaI guarantees the feasibility and compatibility of the electrosynthesis protocol, which enables highly chemoselective synthesis of unsymmetrical N‐acylureas from two different amides, as well as the production of unsymmetrical ...
Xue‐Qing Mou, Xiao Zha, Yu‐Rui Jian, Shao‐Xing Zhong, Xin‐Yu Fu, Sheng‐Yang Xu, Wei Xiang, Bao‐Dong Cui, Yun Zhang, Yong‐Zheng Chen   +9 more
wiley   +1 more source

Therapeutic Appropriateness of Cariprazine in the Management of Schizophrenia: Experts’ Opinion using a Delphi Approach

, 2023
Background: Schizophrenia is a psychiatric disorder whose therapeutic objectives are aimed at reducing symptoms and improving patient's quality of life. First- and second-generation antipsychotics present numerous side effects. Recently introduced in the
Bellomo, Antonello, Domenico De Berardis, Massimo Di Giannantonio, Virginio Salvi, Maria Conca, Andreas Pietro, Berardis, Domenico De, Bernardo Dell’Osso, Salvi, Virginio, Alberto Siracusano, Antonello Bellomo, Andreas Pietro Maria Conca, Carmelo Zaffora, Dell'Osso, Bernardo, Giannantonio, Massimo Di, Zaffora, Carmelo, Siracusano, Alberto   +15 more
core   +1 more source

Characterizing treatment initiation with central nervous system–active polypharmacy among adults with dementia

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Central nervous system (CNS) –active polypharmacy, defined as concurrent use of antidepressants, antipsychotics, anti‐seizure medications, benzodiazepines, nonbenzodiazepine benzodiazepine receptor agonists, opioids, or skeletal muscle relaxants for ≥ 31 consecutive days, poses significant risks patients with dementia.
Donovan T. Maust, Rachel C. Davis, Julie Strominger, Steven C. Marcus, Hyungjin Myra Kim, Tanner Caverly, Frederic C. Blow, Lauren P. Wallner, Sarah Krein, Sarah E. Vordenberg   +9 more
wiley   +1 more source

Social and Clinical Factors Associated With Antipsychotic Medication Discontinuation in Patients With Schizophrenia

International Journal of Methods in Psychiatric Research, Volume 35, Issue 2, June 2026.
ABSTRACT Objectives This study aims to identify social and clinical factors associated with antipsychotic medication discontinuation in patients with schizophrenia. Methods This cross‐sectional case‐control study comprised 111 schizophrenia patients, including 55 who discontinued medication on their own initiative and 56 matched continuous‐treatment ...
Zhengquan Chen, Yiming Wu, Zuowei Wang, Jun Wang, Chao Jiang, Wenchao Shen, Yanting Zheng, Yi Wu   +7 more
wiley   +1 more source

Long-term effects of aripiprazole exposure on monoaminergic and glutamatergic receptor subtypes: comparison with cariprazine [PDF]

, 2019
OBJECTIVE: This study examined the chronic effects of aripiprazole and cariprazine on serotonin (5-HT1A and 5-HT2A) and glutamate (NMDA and AMPA) receptor subtypes.
Adham, N, Tarazi, FI, Gyertyán, István, Choi, YK, Kiss, B   +4 more
core   +1 more source

Pharmacological Management, Safety, and Outcomes in Bipolar Disorder: An Integrated Narrative Review of Clinical and Translational Evidence

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
This graph summarizes bipolar disorder management, showing pharmacological treatments including lithium, valproate, antipsychotics, combination therapy, and emerging agents. It links these treatments to outcomes such as relapse reduction, mortality benefits, and cognitive effects, while highlighting safety issues, poor adherence, pregnancy risks, and ...
Gudisa Bereda
wiley   +1 more source

Volumetric absorptive microsampling for the therapeutic drug monitoring of psychiatric patients treated with cariprazine [PDF]

, 2023
Psychiatric disorders are usually treated with antipsychotic agents belonging to different pharmacological and chemical classes, the most recent ones collectively known as “third-generation antipsychotics”, such as cariprazine, approved in 2015 for the ...
Mondella, Fortunata, Soledad Cárdenas, Alessandro Serretti, Mandrioli, Roberto, Sardella, Roccaldo, Vitagliano, Rosalba, Rosalba Vitagliano, Roberto Mandrioli, Lucena, Rafael, Mercolini, Laura, Jaime Millán-Santiago, Cárdenas, Soledad, Fortunata Mondella, Tomaž Vovk, Millán-Santiago, Jaime, Roccaldo Sardella, Vovk, Tomaž, Federico Boaron, Michele Protti, Laura Mercolini, Rafael Lucena, Carmine Petio, Boaron, Federico   +22 more
core   +1 more source