Results 231 to 240 of about 135,428 (332)

Multi‐Omics Reveals Mechanisms of Metabolic Rejuvenation in Aged Mice and Pre‐Frail Older Men by Losartan

open access: yesAging Cell, Volume 25, Issue 5, May 2026.
Losartan partially reversed serum metabolomic aging signatures in both aged mice and pre‐frail older men, and this effect required functional angiotensin II receptors in mice. Cross‐species analyses suggest aging shifts circulating metabolites in opposite directions in mice versus humans, particularly among lipids, with losartan partially normalizing ...
Michael R. Bene   +13 more
wiley   +1 more source

The Mitochondrial NAD Transporter SLC25A51 in Adipocytes Regulates Adipose Tissue Mitochondrial Function and Systemic Metabolism During Aging

open access: yesAging Cell, Volume 25, Issue 5, May 2026.
We revealed the pathophysiological significance and therapeutic potential of adipocyte mitochondrial NAD transporter, namely solute carrier family 25 member 51 (SLC25A51), in age‐associated metabolic diseases, particularly adipose tissue mitochondrial function, obesity, and insulin resistance, by analyzing adipocyte‐specific Slc25a51 knockout (ASKO ...
Daiki Kojima   +19 more
wiley   +1 more source

Citrate‐Dependent Activation of Acetyl CoA Carboxylase Promotes Renal Lipid Accumulation in a Rat Model of Chronic Kidney Disease

open access: yesActa Physiologica, Volume 242, Issue 5, May 2026.
ABSTRACT Background Abnormal accumulation of lipids within the kidney contributes to the progression of chronic kidney disease, but the underlying metabolic mechanisms remain unclear. Citrate is a central metabolite in cellular energy regulation and is frequently elevated in advanced kidney disease, yet its impact on renal lipid metabolism has not been
Marta Sanz‐Gómez   +8 more
wiley   +1 more source

Guideline of guidelines: Peyronie's disease

open access: yesBJU International, Volume 137, Issue 5, Page 770-782, May 2026.
Objective To compare major Peyronie's disease (PD) guidelines, highlight key similarities and differences among panel recommendations, and identify areas requiring further research. Methods An extensive review was conducted to analyse and compare diagnostic and treatment recommendations from publicly available guidelines published by the American ...
Francesco Chierigo   +7 more
wiley   +1 more source

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