Results 211 to 220 of about 69,736 (263)
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Neurology, 1980
A 29-year-old women had muscle weakness, low concentrations of carnitine in muscle and serum, and abnormally low urinary excretion of carnitine. During a fast, exercise capacity declined, ketone body concentrations rose, metabolic acidosis worsened, and she became hypoglycemic.
J E, Carroll +6 more
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A 29-year-old women had muscle weakness, low concentrations of carnitine in muscle and serum, and abnormally low urinary excretion of carnitine. During a fast, exercise capacity declined, ketone body concentrations rose, metabolic acidosis worsened, and she became hypoglycemic.
J E, Carroll +6 more
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Carnitine, carnitine acyltransferases, and rat brain function
Experimental Neurology, 1982The concentrations of free, short chain, and long chain acylcarnitines and the enzyme activities of carnitine acetyltransferase (CAT) and carnitine palmityltransferase (CPT) were studied in different rat brain regions. The fate of tritium-labeled carnitine was studied in different brain regions in vivo after i.p. injection in 3-month-old Sprague-Dawley
Bresolin N. +3 more
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Carnitine and Carnitine Esters in Acute Renal Failure
Nephrology Dialysis Transplantation, 1989Plasma concentrations of carnitine and carnitine esters were determined in patients with multiple forms of acute renal failure with and without sepsis, and also before and after haemodialysis therapy. Total carnitine, free carnitine, short-chain and long-chain acylcarnitine values of both groups of acute renal failure patients were markedly elevated ...
C, Wanner +3 more
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Transport of carnitine into cells in hereditary carnitine deficiency
Journal of Inherited Metabolic Disease, 1988SummaryCarnitine uptake has been studied in fibroblasts from a case of hereditary carnitine deficiency and in relatives. There was no evidence for carrier‐dependent uptake in cells from the patient. The mother and probably the healthy sister had an impaired uptake. The results show that the defect in this form of carnitine deficiency is an inability to
B O, Eriksson +3 more
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Effect of exogenous carnitine on carnitine homeostasis in the rat
Biochimica et Biophysica Acta (BBA) - General Subjects, 1991The interaction of exogenous carnitine with whole body carnitine homeostasis was characterized in the rat. Carnitine was administered in pharmacologic doses (0-33.3 mumols/100 g body weight) by bolus, intravenous injection, and plasma, urine, liver, skeletal muscle and heart content of carnitine and acylcarnitines quantitated over a 48 h period.
L J, Ruff, L G, Miller, E P, Brass
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Clinical varieties of carnitine and carnitine palmitoyltransferase deficiency
Clinical Biochemistry, 1987Several clinical entities are associated with disorders of fatty acid oxidation or transfer across the inner mitochondrial membrane. Over 40 cases of the primary carnitine deficiency syndrome have been reported to date and various subtypes have been characterized. This represents a large clinical spectrum.
Angelini C. +4 more
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Carnitine, carnitine acetyltransferase, and glutathione in Alzheimer brain
Neurochemical Research, 1995Glutathione and "total" carnitine (i.e., free carnitine plus acid-soluble carnitine esters) were measured in an affected (superior frontal gyrus; SFG) and unaffected (cerebellum: CBL) region of Alzheimer disease (AD) and control brains. Average glutathione content in AD SFG (n = 13) and AD CBL (n = 7) (7.9 +/- 2.1 and 11.9 +/- 4.0 nmol/mg protein ...
T K, Makar +4 more
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Current Genetics, 2008
To date, the only reported metabolic and physiological roles for carnitine in Saccharomyces cerevisiae are related to the activity of the carnitine shuttle. In yeast, the shuttle transfers peroxisomal activated acetyl-residues to the mitochondria. However, acetyl-CoA can also be metabolised by the glyoxylate cycle to form succinate.
Franken, J. +3 more
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To date, the only reported metabolic and physiological roles for carnitine in Saccharomyces cerevisiae are related to the activity of the carnitine shuttle. In yeast, the shuttle transfers peroxisomal activated acetyl-residues to the mitochondria. However, acetyl-CoA can also be metabolised by the glyoxylate cycle to form succinate.
Franken, J. +3 more
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Carnitine transport and tissue carnitine accretion in rats
Biochimica et Biophysica Acta (BBA) - General Subjects, 1990In rats, circulating carnitine levels were highly correlated with skeletal muscle and heart carnitine concentrations over the range of 26-69 microM serum carnitine, but not at higher extracellular carnitine concentrations (70-188 microM). By contrast, circulating carnitine levels over the entire range studied (26-188 microM) correlated with liver and ...
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1999
Carnitine, a name derived from the Latin carnis (flesh), was isolated from meat extracts in 19051 and early its chemical formula (C7H15NO3) was proposed. Its structure, a trimethylbetaine of γ-amino-β-hydroxybutyric acid, was correctly identified and published about twenty years later.2 Initially, some circumstances led to consider carnitine as a ...
CALVANI M. +5 more
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Carnitine, a name derived from the Latin carnis (flesh), was isolated from meat extracts in 19051 and early its chemical formula (C7H15NO3) was proposed. Its structure, a trimethylbetaine of γ-amino-β-hydroxybutyric acid, was correctly identified and published about twenty years later.2 Initially, some circumstances led to consider carnitine as a ...
CALVANI M. +5 more
openaire +4 more sources