Results 201 to 210 of about 69,736 (263)
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Microdetermination of (−)carnitine and carnitine acetyltransferase activity
Analytical Biochemistry, 1977Abstract A method for the determination of picomole amounts of total (−)carnitine and free (−)carnitine in the presence of short-chain acyl(−)carnitines is described. The method is based on the conversion of radioactive acetyl-CoA to acetyl(−)carnitine in the presence of carnitine acetyltransferase and oxidized glutathione or N -ethylmaleimide to ...
R, Parvin, S V, Pande
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Annual Review of Nutrition, 1983
Carnitine has a critical role in energy metabolism. Many of the functions of carnitine are not clearly elucidated and many of the regulatory mechanisms governing carnitine metabolism are ill-defined. Carnitine deficiency can be life threatening but may be resolved with carnitine supplementation.
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Carnitine has a critical role in energy metabolism. Many of the functions of carnitine are not clearly elucidated and many of the regulatory mechanisms governing carnitine metabolism are ill-defined. Carnitine deficiency can be life threatening but may be resolved with carnitine supplementation.
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Biology of the Neonate, 2009
After birth, the main energy fuel for the newborn is constituted by fat. Carnitine is necessary for the β-oxidation of long chain fatty acids at the mitochondrial level, and seems also to have a role in the metabolism of the branched-chain amino acids, in ammonia detoxification, and in urea production.
F F, Rubaltelli +4 more
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After birth, the main energy fuel for the newborn is constituted by fat. Carnitine is necessary for the β-oxidation of long chain fatty acids at the mitochondrial level, and seems also to have a role in the metabolism of the branched-chain amino acids, in ammonia detoxification, and in urea production.
F F, Rubaltelli +4 more
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Metabolic Effects of Carnitine and Carnitine Analogs
1990Cirrhosis of the liver is a common and serious disease with a poor prognosis (1). Loss of liver perfusion and function compromises hepatic detoxification reactions and exposes the central nervous system (CNS) to amino acid imbalances and to multiple toxins including ammonia, mercaptans, short-chain fatty acids, and “middle” molecular weight molecules ...
Y, Ohtsuka, D J, Clark, O W, Griffith
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Journal of Adolescent Health, 1993
Carnitine, abundant in muscle and other tissues, is normally synthesized from lysine. Its major metabolic role is transport of long-chain fatty acids into muscle where beta oxidation takes place. Normative data are available for carnitine levels, but few studies define carnitine of specific age groups.
R, Buchta +3 more
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Carnitine, abundant in muscle and other tissues, is normally synthesized from lysine. Its major metabolic role is transport of long-chain fatty acids into muscle where beta oxidation takes place. Normative data are available for carnitine levels, but few studies define carnitine of specific age groups.
R, Buchta +3 more
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American Journal of Kidney Diseases, 2003
Carnitine, gamma-trimethyl-beta-hydroxybutyrobetaine, is a small molecule widely present in all cells from prokaryotic to eukaryotic. It is an important element in the beta-oxidation of fatty acids. A lack of carnitine in hemodialysis patients is caused by insufficient carnitine synthesis and particularly by the loss through dialytic membranes, leading
BELLINGHIERI, Guido +4 more
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Carnitine, gamma-trimethyl-beta-hydroxybutyrobetaine, is a small molecule widely present in all cells from prokaryotic to eukaryotic. It is an important element in the beta-oxidation of fatty acids. A lack of carnitine in hemodialysis patients is caused by insufficient carnitine synthesis and particularly by the loss through dialytic membranes, leading
BELLINGHIERI, Guido +4 more
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Annual Review of Pharmacology and Toxicology, 1987
Camitine (3-hydroxy-4-N-trimethylaminobutyric acid; see Figure 1) was iso lated from meat in 1905 ( l ). In 1959 Fritz (2) demonstrated that camitine has an obligatory role in long-chain fatty acid (LCFA) oxidation. Cederblad & Lindstedt (3) developed a sensitive assay in 1972, which was later modified by McGarry & Foster (4).
J J, Bahl, R, Bressler
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Camitine (3-hydroxy-4-N-trimethylaminobutyric acid; see Figure 1) was iso lated from meat in 1905 ( l ). In 1959 Fritz (2) demonstrated that camitine has an obligatory role in long-chain fatty acid (LCFA) oxidation. Cederblad & Lindstedt (3) developed a sensitive assay in 1972, which was later modified by McGarry & Foster (4).
J J, Bahl, R, Bressler
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[Catabolism of carnitine: products of carnitine decarboxylase and carnitine dehydrogenase in vivo].
Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 19811) Rats and mice were given large oral or subcutaneous doses of (-)-L-, (+)-D- and DL-carnitine (5 mg/g body weight). The carnitine metabolites, beta-methylcholine and acetonyltrimethylammonium, were isolated from the urine by special methods, and determined as their characteristic derivatives (2,4-dinitrophenylhydrazone and butyric ester) by thin ...
H, Seim, H, Löster, E, Strack
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Conversion of D-carnitine into L-carnitine with stereospecific carnitine dehydrogenases
Biotechnology Letters, 1997D-Carnitine was converted to L-carnitine by resting and permeabilized cells as well as with purified stereospecific carnitine dehydrogenases from Agrobacterium sp. With permeabilized cells only 11% of D-carnitine was converted into L-carnitine. Using highly stereospecific D- and L-carnitine dehydrogenases from Agrobacterium sp.
Henning Hanschmann, Hans-Peter Kleber
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Pathology, 1985
Carnitine is an essential cofactor in the transfer of long-chain fatty acids across the inner mitochondrial membrane. Carnitine is metabolized from lysine, trimethyllysine and butyrobetaine. Butyrobetaine undergoes hydroxylation in the liver, brain and kidney to form carnitine which in turn is transported via the plasma to the heart and skeletal muscle
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Carnitine is an essential cofactor in the transfer of long-chain fatty acids across the inner mitochondrial membrane. Carnitine is metabolized from lysine, trimethyllysine and butyrobetaine. Butyrobetaine undergoes hydroxylation in the liver, brain and kidney to form carnitine which in turn is transported via the plasma to the heart and skeletal muscle
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