Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
Nature Medicine, 2013 Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO).
Robert A. Koeth +22 more
semanticscholar +1 more source
Carnitine in Human Muscle Bioenergetics: Can Carnitine Supplementation Improve Physical Exercise?
Molecules, 2020 l-Carnitine is an amino acid derivative widely known for its involvement in the transport of long-chain fatty acids into the mitochondrial matrix, where fatty acid oxidation occurs.
A. Gnoni +3 more
semanticscholar +1 more source
Regulation of genes involved in carnitine homeostasis by PPARa across different species (rat, mouse, pig, cattle, chicken, and human) [PDF]
, 2012 Recent studies in rodents convincingly demonstrated that PPAR-alpha is a key regulator of genes involved in carnitine homeostasis, which serves as a reasonable explanation for the phenomenon that energy deprivation and fibrate treatment, both of which ...
Egeri, Leonie +4 more
core +1 more source
l-carnitine in critically ill patients—a case series study
Renal Replacement Therapy, 2018 Background l-carnitine is essential for lipid metabolism, and lack of l-carnitine intake and loss by treatments lead to carnitine depletion causing muscle weakness, anemia, and immune dysfunction.
Takehiko Oami +6 more
doaj +1 more source
Circulating Carnitine Levels and Breast Cancer: A Matched Retrospective Case-Control Study
Frontiers in Oncology, 2022 IntroductionEpidemiological studies investigating the association between carnitine and breast cancer are scarce.Materials and MethodsThis 1:1 age-matched retrospective case-control study identified 991 female breast cancer cases and 991 female controls ...
Jiayi Zhang +9 more
doaj +1 more source
Effects of exercise on l-carnitine and lipid metabolism in African catfish (Clarias gariepinus) fed different dietary l-carnitine and lipid levels [PDF]
, 2010 African catfish (Clarias gariepinus) were fed four isonitrogenous diets (34 % crude protein), each containing one of two lipid (100 or 180 g/kg) and two l-carnitine (15 or 1000 mg/kg) levels. After 81 d of feeding, thirty-two fish (body weight 32 g) from
Bessa, R.J.B. +5 more
core +2 more sources
Effect of Combined Oral Ferrotherapy with L-carnitine on Exercise Tolerance of Patients with Chronic Heart Failure with Reduced Ejection Fraction of Left Ventricle with Concomitant Iron Deficiency Anemia [PDF]
, 2019 According to numerous studies, a high prevalence of iron deficiency (ID) with anaemic syndrome and its association with mortality during chronic heart failure (CHF) have been revealed.
Ivanov, V. (Valerii) +1 more
core +3 more sources
The EuroBiotech Journal, 2021 Carnitine (β-hydroxy-γ-trimethyl amino butyrate) is, a vitamin-like substance carrying long-chain fatty acids into the mitochondrial matrix. Due to its effect in energy metabolism, carnitine plays an important role in controlling diabetes and its ...
Özer Şehriban Duyar +1 more
doaj +1 more source
Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota [PDF]
, 2014 Dietary intake of L-carnitine can promote cardiovascular diseases in humans through microbial production of trimethylamine (TMA) and its subsequent oxidation to trimethylamine N-oxide (TMAO) by hepatic flavin-containing monooxygenases.
Bugg, Tim +6 more
core +1 more source
Potential TMA-Producing Bacteria Are Ubiquitously Found in Mammalia
Frontiers in Microbiology, 2020 Human gut bacteria metabolize dietary components such as choline and carnitine to trimethylamine (TMA) that is subsequently oxidized to trimethylamine-N-oxide (TMAO) by hepatic enzymes.
Silke Rath +4 more
doaj +1 more source