Results 41 to 50 of about 425,158 (263)

Heat transport with advection in fractured rock [PDF]

, 2019
In the transport of heat in porous media, diffusion generally dominates over advection due to slow fluid velocities imposed by low permeability. This is the reason why standard Galerkin formulation leading to extra non-symmetric matrix terms may be still
Carol, Ignacio, Prat Catalán, Pere, Pérez Carreras, Adrià   +2 more
core  

How to Conduct a Multi‐Domain Systematic (Literature) Review? Guidelines Using The Lotus Protocol

Psychology &Marketing, EarlyView.
ABSTRACT Complex challenges increasingly demand multidisciplinary research across intersecting knowledge domains. However, existing systematic (literature) review protocols offer limited guidance and tend to confine scholars to single‐domain or single‐intersection reviews.
Bart J. A. van Bueren, Weng Marc Lim, Naveen Donthu, Kevin Argus, Julian M. Water‐Lynch, Alvedi Sabani, Mark A. A. M. Leenders   +6 more
wiley   +1 more source

p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response

Nature Communications
Activation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress. However, the molecular mechanisms by which p53 controls gene transcription are not completely understood. Here, we uncover the critical role
François Serra, Andrea Nieto-Aliseda, Lucía Fanlo-Escudero, Llorenç Rovirosa, Mónica Cabrera-Pasadas, Aleksey Lazarenkov, Blanca Urmeneta, Alvaro Alcalde-Merino, Emanuele M. Nola, Andrei L. Okorokov, Peter Fraser, Mariona Graupera, Sandra D. Castillo, Jose L. Sardina, Alfonso Valencia, Biola M. Javierre   +15 more
doaj   +1 more source

The Weak Core, Partition‐Based Universal Stability, and Their Risk Associations Through A Partial Order

Naval Research Logistics (NRL), EarlyView.
ABSTRACT We are concerned with the stability of a transferable‐utility cooperative (TU) game. First, the concept of core can be weakened so that the blocking of changes is limited to only those with multilateral backings. This principle of consensual blocking, as well as the traditional core‐defining one of unilateral blocking and one straddling in ...
Jian Yang
wiley   +1 more source

The onset of PI3K‐related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib

EMBO Molecular Medicine, 2022
Low‐flow vascular malformations are congenital overgrowths composed of abnormal blood vessels potentially causing pain, bleeding and obstruction of different organs.
Piotr Kobialka, Helena Sabata, Odena Vilalta, Leonor Gouveia, Ana Angulo‐Urarte, Laia Muixí, Jasmina Zanoncello, Oscar Muñoz‐Aznar, Nagore G Olaciregui, Lucia Fanlo, Anna Esteve‐Codina, Cinzia Lavarino, Biola M Javierre, Veronica Celis, Carlota Rovira, Susana López‐Fernández, Eulàlia Baselga, Jaume Mora, Sandra D Castillo, Mariona Graupera   +19 more
doaj   +1 more source

Developing a serocorrelate of protection against invasive group B streptococcus disease in pregnant women: a feasibility study. [PDF]

, 2019
BACKGROUND: Group B streptococcus is the leading cause of infection in infants. Currently, intrapartum antibiotic prophylaxis is the major strategy to prevent invasive group B streptococcus disease.
Andrews, N, Carreras-Abad, C, Cochet, M, Djennad, A, Hall, T, Hamid, R, Heath, P, Khalil, A, Le Doare, K, Peregrine, E, Planche, T, Plumb, J, Ramkhelawon, L, Sheridan, E, Sivarajan, S, Vinayakarao, L, Winchester, S   +16 more
core   +1 more source

Ruthenium‐Catalyzed CH Alkenylation of Trypanocidal Naphthoquinones: A Mechanistic Benchmarking Study

ChemistryOpen, EarlyView.
Computational roadmap to click‐ready quinones. Quantum chemical analysis reveals how substituents modulate the reactivity of trypanocidal naphthoquinones in Ru‐catalyzed CH alkenylation, guiding the design of sulfonyl‐fluoride scaffolds for next‐generation antiparasitic agents.
Esther R. S. Paz, Cauê P. Souza, Joyce C. De Oliveira, Renata G. Almeida, Chonny Herrera‐Acevedo, Sulaiman Lakoh, Guilherme A. M. Jardim, Eufrânio N. da Silva Júnior, Felipe Fantuzzi   +8 more
wiley   +1 more source

Navigating the Rapids: How Non‐Governmental Organization Managers Develop Strategic Adaptation to Repressive Political Environments

Public Administration and Development, EarlyView.
ABSTRACT This article explores the management adaptation strategies non‐governmental organizations (NGOs) managers employ in order to operate in repressive political environments. It answers the question: how do NGO managers initiate, manage and sustain internal change when the political/regulatory environment changes?
Charles Kaye‐Essien, Shahjahan Bhuiyan, Ghadeer Ali   +2 more
wiley   +1 more source

DETECCIÓN DE CAMBIOS NO SUPERVISADA DE IMÁGENES SAR PARA EL SEGUIMIENTO DEL COMPORTAMIENTO Y ANÁLISIS DE INUNDACIONES EN COLOMBIA

Revista de Investigaciones Universidad del Quindío, 2015
Este trabajo propone un método no supervisado de detección cambios para el estudio del comportamiento de las inundaciones en Colombia usando imágenes SAR (Synthetic Aperture Radar).
Jonathan Avendaño P, Jorge I. Padilla, Jhon E. Vera, Jaime A. Parra   +3 more
doaj   +1 more source

Land data assimilation of satellite‐based surface soil moisture: Impact on atmospheric simulations over the contiguous United States

Quarterly Journal of the Royal Meteorological Society, EarlyView.
Soil Moisture Active Passive soil moisture retrievals are assimilated into a land surface model and the resulting land reanalysis product is used to initialise the land component of coupled land‐atmosphere experiments. We show that the local impact of land data assimilation on the atmosphere is influenced by two factors: the magnitude by which it ...
Zdenko Heyvaert, Michel Bechtold, Wouter Dorigo, Jonas Mortelmans, Daniel Hagan, Joseph Santanello, Gabriëlle De Lannoy   +6 more
wiley   +1 more source