Results 231 to 240 of about 7,114,272 (394)
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner +4 morewiley +1 more sourceEffective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet +17 morewiley +1 more sourceThe impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applications. [PDF]
Front PharmacolDu J, Shen M, Chen J, Yan H, Xu Z, Yang X, Yang B, Luo P, Ding K, Hu Y, He Q. +10 moreeuropepmc +1 more sourceMitochondrial protein import [PDF]
, 1989 Ades, Ades, Adrian, Ainger, Allison, Alt, Aquila, Aquila, Arakawa, Arends, Argan, Argan, Baker, Banroques, Basile, Beckmann, Bedwell, Behra, Bellion, Beltzer, Beltzer, Berkhout, Bhasker, Bhat, Blobel, Borst, Bouillaud, Boutry, Brandriss, Braun, Burns, Böhni, Böhni, Cerletti, Chatton, Chen, Chen, Chen, Chen, Chen, Cheng, Chien, Chien, Chirico, Chu, Conboy, Conboy, Coruzzi, Craig, Dahl, Daum, Daum, De Haan, De Jong, De Lange, De Lange, Deshaies, Dickerson, Dieckmann, Dieckmann, Douglas, Duffaud, Dumont, Eilers, Eilers, Eilers, Ellis, Ellis, Emr, Epand, Evans, Farrell, Farrell, Faye, Firgaira, Fisher, Flügge, Foury, Fox, Freeman, Freitag, Fujiki, Fujiki, Gabellini, Gabellini, Gasser, Gasser, Gasser, Gay, Gearing, Geller, Gillespie, Gilmore, Gilmore, Grant, Grossmann, Guiard, Hackenbrock, Hallemayer, Hallermayer, Hallewell, Hampsey, Hansen, Harmey, Harmey, Harmey, Harmey, Harnisch, Hartl, Hartl, Hartl, Hartl, Hase, Hase, Hase, Hatalova, Hauska, Hawlitschek, Hay, Heinrich, Hemmingsen, Hennig, Hennig, Hennig, Henning, Hensgen, Ho, Ho, Horwich, Horwich, Horwich, Horwich, Horwich, Horwich, Hunter, Hurt, Hurt, Hurt, Hurt, Hurt, Hurt, Hurt, Hurt, Imanaka, Ito, Jaussi, Jaussi, Joh, Just, Kanazawa, Kaput, Kellems, Kellems, Kellens, Keng, Kirwin, Kleene, Koerner, Koerner, Koike, Kolansky, Kolarov, Korb, Kraus, Kraus, Kraus, Kraus, Krebs, Kruse, Kryzwicki, Kun, Labouesse, Lazarow, Lederer, Lennart-Nilsson, Lewin, Lewin, Lindquist, Lingelbach, Lomax, Lubben, Lustig, Lustig, Maarse, Maarse, Maccecchini, Maccecchini, Macino, Maher, Marres, Marzuki, Matsubara, Matsuura, McAda, McGraw, McIntyre, Meyer, Meyer, Meyer, Michel, Mihara, Mihara, Mihara, Mihara, Miura, Miura, Mori, Mori, Morita, Morohashi, Morohashi, Morohashi, Mueckler, Mueckler, Mueckler, Myers, Myers, Müller, Müller, Nagata, Nakagawa, Nargang, Natsoulis, Nelson, Nelson, Ness, Neupert, Neupert, Nguyen, Nguyen, Nguyen, Nguyen, Nicholson, Nicholson, Nicholson, Nicholson, Nishikimi, Nyunoya, Oda, Oda, Ohashi, Ohba, Ohba, Ohta, Ohta, Okamura, Okamura, Ono, Ono, Ono, Ono, Ou, Ou, Oudshoorn, Pain, Pain, Pape, Pape, Park, Patterson, Pelham, Perara, Pfaller, Pfaller, Pfaller, Pfaller, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pillar, Pollock, Pratje, Pratje, Randall, Randall, Raymond, Reid, Reid, Richter, Ricquier, Ridley, Rietveld, Riezman, Riezman, Riezman, Robinson, Roise, Roise, Rothblatt, Rothman, Runswick, Rödel, Römisch, Sabatini, Sachs, Sadler, Saraste, Schatz, Schlenstedt, Schleyer, Schleyer, Schleyer, Schmeizer, Schmidt, Schmidt, Schmidt, Schmidt, Schmidt, Schneller, Schwaiger, Schägger, Sebald, Shore, Sidhu, Sierra, Simmaco, Skerjank, Smagula, Stellwagen, Stuart, Suissa, Suissa, Surguchov, Suske, Sztul, Söllner, Takeda, Takeda, Takiguchi, Tamm, Taniuchi, Teintze, Tropschug, Tzagoloff, Tzagoloff, Ueda, Urban-Grimal, Van Loon, Van Loon, Van Loon, Van Loon, Van Loon, Van Loon, Van Loon, Van Loon, Van Steeg, Vasarotti, Vasarotti, Veloso, Velours, Verner, Vestweber, Viebrock, Von Heijne, Walter, Walter, Walter, Watanabe, Waters, Watts, Weiss, Werner, Wickner, Wiech, Wielburski, Wierenga, Witte, Wold, Woodrow, Wright, Wright, Wu, Yaffe, Yaffe, Yamane, Yoshida, Yoshida, Young, Zimmermann, Zimmermann, Zimmermann, Zimmermann, Zimmermann, Zimmermann, Zwizinski, Zwizinski, Zwizinski, Zwizinski +395 morecore +1 more sourceExploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair +17 morewiley +1 more source
