Results 81 to 90 of about 39,628 (288)

From protein binding to pharmacokinetics: a novel approach to active drug absorption prediction [PDF]

arXiv, 2008
Due to inherent complexity active transport presents a landmark hurdle for oral absorption properties prediction. We present a novel approach carrier-mediated drug absorption parameters calculation based on entirely different paradigm than QSPR. We capitalize on recently emerged ideas that molecule activities against a large protein set can be used for
arxiv  

Protein Carrier AAV

ABSTRACTAAV is widely used for efficient delivery of DNA payloads. The extent to which the AAV capsid can be used to deliver a protein payload is unexplored. Here, we report engineered AAV capsids that directly package proteins – Protein Carrier AAV (pcAAV).
Mareike D. Hoffmann, Ryan J. Sorensen, Ajay Extross, Yungui He, Daniel Schmidt   +4 more
openaire   +2 more sources

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

A Review of Whey Protein-Based Bioactive Delivery Systems: Design, Fabrication, and Application

Foods
The efficacy of many edible bioactive agents is limited by their low water dispersibility and chemical instability in foods, as well as by their poor bioaccessibility, low absorption, and metabolism within the human gastrointestinal tract.
Liming Jiang, Zhiheng Zhang, Chao Qiu, Jinsheng Wen   +3 more
doaj   +1 more source

Hemelipoglycoprotein from the ornate sheep tick, dermacentor marginatus: structural and functional characterization

Parasites & Vectors, 2011
Background Tick carrier proteins are able to bind, transport, and store host-blood heme, and thus they function also as antioxidants. Nevertheless, the role of carrier proteins in ticks is not fully understood.
Sterba Jan, Dupejova Jarmila, Vancova Marie, Grubhoffer Libor   +3 more
doaj   +1 more source

The Acyl‐Carrier Protein of Citrate Lyase [PDF]

European Journal of Biochemistry, 1973
When [14C]acetyl citrate lyase was dissociated in sodium dodecylsulfate and the products were separated by gel electrophoresis, all of the radioactive label appeared in a small protein. This had a molecular weight of about 10000 and contained phosphopantetheine.
Peter Dimroth, Hermann Eggerer, Gundel Walther, Wolfgang Dittmar   +3 more
openaire   +3 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Acyl Carrier Protein

Journal of Biological Chemistry, 1970
Abstract β-Ketoacyl acyl carrier protein (ACP) synthetase, which catalyzes the condensation of fatty acyl-ACP with malonyl-ACP to form β-ketoacyl-ACP, has been crystallized in a highly active form which is stable for several months. Phosphate has been shown to cause enzyme activation which may be due to a conformational change of the protein. Guanidine
Vagelos Pr, Prescott Dj
openaire   +5 more sources

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

FEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source