Results 61 to 70 of about 8,126,655 (341)

A conserved motif flags Acyl Carrier Proteins for β-branching in polyketide synthesis

Nature Chemical Biology, 2013
Type I PKSs often utilise programmed β-branching, via enzymes of an “HMG-CoA synthase (HCS) cassette”, to incorporate various side chains at the second carbon from the terminal carboxylic acid of growing polyketide backbones.
A. Haines, Xu Dong, Zhongshu Song, R. Farmer, Christopher Williams, J. Hothersall, Eliza Płoskoń, P. Wattana-Amorn, Elton R. Stephens, Erika Yamada, R. Gurney, Yuiko Takebayashi, J. Masschelein, Russell John Cox, R. Lavigne, C. Willis, T. J. Simpson, J. Crosby, P. Winn, Christopher M Thomas, M. Crump   +20 more
semanticscholar   +1 more source

Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan, Lydie Da Costa, Ludivine David Nguyen, Heloise Chosseler, Audrey Riquet, Benedicte Bruno, Melissa Barbati   +6 more
wiley   +1 more source

Hydroxyethyl cellulose matrix applied to serial crystallography

Scientific Reports, 2017
Serial femtosecond crystallography (SFX) allows structures of proteins to be determined at room temperature with minimal radiation damage. A highly viscous matrix acts as a crystal carrier for serial sample loading at a low flow rate that enables the ...
Michihiro Sugahara, Takanori Nakane, Tetsuya Masuda, Mamoru Suzuki, Shigeyuki Inoue, Changyong Song, Rie Tanaka, Toru Nakatsu, Eiichi Mizohata, Fumiaki Yumoto, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Osamu Nureki, Keiji Numata, Eriko Nango, So Iwata   +18 more
doaj   +1 more source

An Overview on Spray-Drying of Protein-Loaded Polymeric Nanoparticles for Dry Powder Inhalation

Pharmaceutics, 2020
The delivery of therapeutic proteins remains a challenge, despite recent technological advances. While the delivery of proteins to the lungs is the gold standard for topical and systemic therapy through the lungs, the issue still exists.
Tânia Marante, Cláudia Viegas, Inês Duarte, Ana S. Macedo, Pedro Fonte   +4 more
doaj   +1 more source

Mutational Analysis of the QRRQ Motif in the Yeast Hig1 Type 2 Protein Rcf1 Reveals a Regulatory Role for the Cytochrome \u3cem\u3ec\u3c/em\u3e Oxidase Complex [PDF]

, 2017
The yeast Rcf1 protein is a member of the conserved family of proteins termed the hypoxia-induced gene (domain) 1 (Hig1 or HIGD1) family. Rcf1 interacts with components of the mitochondrial oxidative phosphorylation system, in particular the cytochrome ...
Garlich, Joshua, Strecker, Valentina, Stuart, Rosemary A., Wittig, Ilka   +3 more
core   +1 more source

Oxidative Protein-Folding Systems in Plant Cells

International Journal of Cell Biology, 2013
Plants are unique among eukaryotes in having evolved organelles: the protein storage vacuole, protein body, and chloroplast. Disulfide transfer pathways that function in the endoplasmic reticulum (ER) and chloroplasts of plants play critical roles in the
Yayoi Onda
doaj   +1 more source

Glucose transporters as markers of diagnosis and prognosis in cancer diseases

Oncology Reviews, 2022
Glucose is a main metabolic substrate, which plays a role as a source of energy and a substrate in several processes. Cell membrane is lipophilic, whereas monosaccharides are hydrophilic.
Leszek Szablewski
doaj   +1 more source

Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers (mTOT)—Relationship to Newly Identified Mitochondrial Pyruvate Carrier Proteins

PLoS ONE, 2013
Thiazolidinedione (TZD) insulin sensitizers have the potential to effectively treat a number of human diseases, however the currently available agents have dose-limiting side effects that are mediated via activation of the transcription factor PPARγ.
J. Colca, W. G. McDonald, G. Cavey, Serena L. Cole, Danielle D. Holewa, Angela S. Brightwell-Conrad, C. L. Wolfe, J. Wheeler, Kristin R. Coulter, Peter M. Kilkuskie, E. Gracheva, Y. Korshunova, M. Trusgnich, Robert Karr, S. Wiley, Ajit S. Divakaruni, A. Murphy, P. Vigueira, B. Finck, R. Kletzien   +19 more
semanticscholar   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Transport of proteins into mitochondria [PDF]

, 1985
The transfer of cytoplasmically synthesized precursor proteins into or across the inner mitochondrial membrane is dependent on energization of the membrane.
Neupert, Walter, Pfanner, Nikolaus
core