Results 41 to 50 of about 9,648,893 (334)

Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-inducing Chemotherapies

Cancer Cell, 2015
Summary Many tumor cells are fueled by altered metabolism and increased glutamine (Gln) dependence. We identify regulation of the L-glutamine carrier proteins SLC1A5 and SLC38A2 (SLC1A5/38A2) by the ubiquitin ligase RNF5.
Y. Jeon, Sihem Khelifa, B. Ratnikov, D. Scott, Yongmei Feng, Fabio Parisi, Chelsea M. Ruller, E. Lau, Hyungsoo Kim, L. Brill, Tingting Jiang, D. Rimm, R. Cardiff, G. Mills, Jeffrey W. Smith, A. Osterman, Y. Kluger, Z. Ronai   +17 more
semanticscholar   +1 more source

Mitochondrial Protein Import [PDF]

, 1987
The role of nucleoside triphosphates (NTPs) in mitochondrial protein import was investigated with the precursors of N. crassa ADP/ATP carrier, F1-ATPase subunit β, F0-ATPase subunit 9, and fusion proteins between subunit 9 and mouse dihydrofolate ...
Pfanner, Nikolaus, Tropschug, Maximilian, Neupert, Walter   +2 more
core   +1 more source

A crucial role of the mitochondrial protein import receptor MOM19 for the biogenesis of mitochondria [PDF]

, 1994
The novel genetic method of "sheltered RIP" (repeat induced point mutation) was used to generate a Neurospora crassa mutant in which MOM19, a component of the protein import machinery of the mitochondrial outer membrane, can be depleted.
W Neupert, Lill, Roland, Harkness, Troy A.A.,, van der Klei, Ida, Neupert, Walter, Harkness, Troy A. A., Klei, Ida J. van der, TA Harkness, Klei, Ida van der,, Nargang, Frank E.,, I van der Klei, Neupert, Walter,, Lill, Roland,, van der Klei, Ida ; id_orcid, Nargang, Frank E., FE Nargang, R Lill   +16 more
core   +3 more sources

A review on protein based nanocarriers for polyphenols: interaction and stabilization mechanisms

Food Innovation and Advances, 2023
Protein has been used as the carrier for protecting and targeting polyphenols and increasing their shelf-life. Interactions of a protein molecule with polyphenols are important, which change functions and physiochemical properties of the complex and ...
Yun Xiao, Talha Ahmad, Tarun Belwal, Rana Muhammad Aadil, Muhammad Siddique, Limin Pang, Yanqun Xu   +6 more
doaj   +1 more source

Induced circular dichroism as a tool to investigate the binding of drugs to carrier proteins: Classic approaches and new trends.

Journal of Pharmaceutical and Biomedical Analysis, 2015
Induced circular dichroism (ICD) is a spectroscopic phenomenon that provides versatile and useful methods for characterizing the structural and dynamic properties of the binding of drugs to target proteins.
D. Tedesco, C. Bertucci
semanticscholar   +1 more source

Legionella pneumophila secretes a mitochondrial carrier protein during infection.

PLoS Pathogens, 2012
The Mitochondrial Carrier Family (MCF) is a signature group of integral membrane proteins that transport metabolites across the mitochondrial inner membrane in eukaryotes. MCF proteins are characterized by six transmembrane segments that assemble to form
Pavel Dolezal, Margareta Aili, Janette Tong, Jhih-Hang Jiang, Carlo M T Marobbio, Sau Fung Lee, Ralf Schuelein, Simon Belluzzo, Eva Binova, Aurelie Mousnier, Gad Frankel, Giulia Giannuzzi, Ferdinando Palmieri, Kipros Gabriel, Thomas Naderer, Elizabeth L Hartland, Trevor Lithgow   +16 more
doaj   +1 more source

Ligands and carriers for enhancing immune activity: Mechanisms of action and prospects for applications in medicine and biotechnology

Медицинская иммунология
This article provides a comprehensive overview of research focusing on the role of antibodies, cytokines, complement proteins, major histocompatibility complex (MHC) molecules, and Toll-like receptors (TLRs) in the immune response and their potential as ...
S. S. Gogina, A. M. Stoinova
doaj   +1 more source

Insights on the Quest for the Structure–Function Relationship of the Mitochondrial Pyruvate Carrier

Biology, 2020
The molecular identity of the mitochondrial pyruvate carrier (MPC) was presented in 2012, forty years after the active transport of cytosolic pyruvate into the mitochondrial matrix was first demonstrated.
José Edwin Neciosup Quesñay, Naomi L. Pollock, Raghavendra Sashi Krishna Nagampalli, Sarah C. Lee, Vijayakumar Balakrishnan, Sandra Martha Gomes Dias, Isabel Moraes, Tim R. Dafforn, Andre Luis Berteli Ambrosio   +8 more
doaj   +1 more source

Presentation matters: Impact of association of amphiphilic LPS with serum carrier proteins on innate immune signaling. [PDF]

PLoS ONE, 2018
Recognition of Pathogen-associated Molecular Patterns (PAMPs) by Toll-like receptors is central to innate immunity. Many bacterial PAMPs such as lipopolysaccharide (LPS) and lipoteichoic acid have amphiphilic properties. The hydrophobicity of amphiphilic
Loreen R Stromberg, Heather M Mendez, Jessica Z Kubicek-Sutherland, Steven W Graves, Nicolas W Hengartner, Harshini Mukundan   +5 more
doaj   +1 more source

The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins

Proteins: Structure, Function, and Bioinformatics, 2014
Carrier proteins (CPs) play a critical role in the biosynthesis of various natural products, especially in nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) enzymology, where the CPs are referred to as peptidyl‐carrier proteins (PCPs ...
J. Lohman, M. Ma, M. Cuff, L. Bigelow, J. Bearden, G. Babnigg, A. Joachimiak, G. N. Phillips, B. Shen   +8 more
semanticscholar   +1 more source