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Integrins in Articular Cartilage
2008In the following sections, we primarily review our own work on the expression, tissue distribution and function of integrins in selected in vitro models of articular chondrocytes and limb bud mesenchymal cells. The expression pattern of α1-, α3-, αv- and α5β1-integrins and their specific ligand binding were investigated in monolayer cultures of ...
Shakibaei, M, Csaki, C, Mobasheri, A
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Journal of the American Academy of Orthopaedic Surgeons, 2003
Articular cartilage is a complex tissue maintained by chondrocytes, which undergo metabolic changes as a result of aging, disease, and injury. These changes may hinder tissue maintenance and repair, resulting in accelerated loss of articular surface and leading to end-stage arthritis.
Michael, Ulrich-Vinther +4 more
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Articular cartilage is a complex tissue maintained by chondrocytes, which undergo metabolic changes as a result of aging, disease, and injury. These changes may hinder tissue maintenance and repair, resulting in accelerated loss of articular surface and leading to end-stage arthritis.
Michael, Ulrich-Vinther +4 more
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The American Journal of Sports Medicine, 1998
Articular cartilage can tolerate a tremendous amount of intensive and repetitive physical stress. However, it manifests a striking inability to heal even the most minor injury. Both the remarkable functional characteristics and the healing limitations reflect the intricacies of its structure and biology.
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Articular cartilage can tolerate a tremendous amount of intensive and repetitive physical stress. However, it manifests a striking inability to heal even the most minor injury. Both the remarkable functional characteristics and the healing limitations reflect the intricacies of its structure and biology.
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Permeability of Articular Cartilage
Nature, 1968IN 1962, McCutcheon1 first drew attention to a decrease in the permeability of articular cartilage with increasing depth from the surface. This observation has been confirmed2 and the permeability shown to be inversely related to the fixed charge density of the cartilage matrix.
A, Maroudas, P, Bullough
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Immunogenicity of Allograft Articular Cartilage
The Journal of Bone & Joint Surgery, 1974Allograft articular cartilage was transplanted between inbred strains of rats and between rabbits. Three forms of allograft were employed: isolated articular chondrocytes, shavings of articular cartilage, and intact articular surfaces. Immunological assessment with the leukocyte migration technique for cell-mediated immunity and Cr51 cytotoxicity for ...
F, Langer, A E, Gross
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Clinical Orthopaedics and Related Research, 2002
The acute and repetitive impact and torsional joint loading that occurs during participation in sports can damage articular surfaces causing pain, joint dysfunction, and effusions. In some instances, this articular surface damage leads to progressive joint degeneration. Three classes of chondral and osteochondral injuries can be identified based on the
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The acute and repetitive impact and torsional joint loading that occurs during participation in sports can damage articular surfaces causing pain, joint dysfunction, and effusions. In some instances, this articular surface damage leads to progressive joint degeneration. Three classes of chondral and osteochondral injuries can be identified based on the
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The collagens of articular cartilage
Seminars in Arthritis and Rheumatism, 1991Articular cartilage contains at least five genetically distinct types of collagen. Types II, IX, and XI are cartilage-specific and are cross-linked together in a copolymeric network that forms the extracellular framework of the tissue. Fibrils of type II collagen provide the basic architecture.
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Ultrastructure of articular cartilage
Zeitschrift f�r Zellforschung und Mikroskopische Anatomie, 1959The present paper describes an electron microscopical investigation into the ultrastructure of patellary and femorocondylar articular cartilage from adult guinea pigs, mice and young rats. The following observations were made: 1. The intercellular matrix contains two varieties of collagen fibrils, one being 85 A in diameter and not striated, the ...
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Smart Biomaterials for Articular Cartilage Repair and Regeneration
Advanced Functional Materials, 2023Hongyan He, Qi Gan
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