Results 41 to 50 of about 86,499 (264)

Therapeutic Extracellular Vesicles from Synovial Fibroblast‐Primed MSCs for Osteoarthritis Treatment

Advanced Healthcare Materials, EarlyView.
EVs derived from the microenvironment of SFs transferred MSCs (miSF‐MSC‐EVs) enhanced the expression of miRNAs that regulate cell migration, cell adhesion, and the TGF‐β signaling pathway, demonstrating superior anti‐inflammatory and cartilage regeneration effects compared to conventional MSC‐EVs.
Seo Jeong Kim, Ji Seob Kim, Min Hee Moon, Jae‐Hyeok Jang, In Sun Hwang, Byung‐Hyun Cha   +5 more
wiley   +1 more source

Recent progress of hydrogel-based biomimetic articular cartilage in mechanical and lubricated enhancement

Friction
Articular cartilage covering a joint surface provides excellent lubrication and a load-bearing interface for the daily activities of the human body, which is characterized by high load-bearing, low friction, and wear resistance.
Qin Chen, Kai Chen, Xinyue Zhang, Haiyan Feng, Cunao Feng, Xiaowei Li, Dekun Zhang   +6 more
doaj   +1 more source

Cartilaginous Organoids: Advances, Applications, and Perspectives

Advanced NanoBiomed Research, 2023
Cartilage is a nonvascular and non‐neural, mesoderm‐derived tissue. Cartilage repair, especially articular cartilage repair and reconstruction, has always been a difficult problem in bone tissue engineering.
Yuhao Yu, Juan Wang, Yamin Li, Yunsu Chen, Wenguo Cui   +4 more
doaj   +1 more source

Engineering Layered Magnetic Hydrogels for Cell Placement via Shear and Magnetic Field‐Induced Assembly

Advanced Materials, EarlyView.
Magnetic particles are organized into layered architectures by combining shear flow and magnetic fields, with the resulting structures governed by appropriate Mason numbers. The programmed assemblies provide spatial guidance for cell placement, linking field‐controlled self‐assembly, flow‐induced structuring and biological organization.
Guillermo Camacho, Jose R. Morillas, Jesús García‐Gutiérrez, Stefania Nardecchia, Óscar Martínez‐Cano, Juan de Vicente   +5 more
wiley   +1 more source

Does radiofrequency ablation (RFA) epiphysiodesis affect adjacent joint cartilage?

Journal of Children's Orthopaedics, 2016
Purpose To test the hypothesis that epiphysiodesis made with radiofrequency ablation (RFA) is a safe procedure that disrupts the growth plate without damaging the adjacent joint articular cartilage.
Juan Manuel Shiguetomi-Medina, O. Rahbek, A. A. H. Abood, H. Stødkilde-Jørgensen, J. L. Ramírez Garcia-Luna, B. Møller-Madsen   +5 more
doaj   +1 more source

Neutron Reflectometry and Compression of Graded Hydrogel Surfaces

Advanced Materials Interfaces, EarlyView.
Highly‐entangled and covalently‐crosslinked hydrogels with thin and thick surface gel layers are compressed in neutron reflectometry experiments. Surface gel layer thickness dictates the extent to which the polymer network at the surface of a hydrogel collapses, while crosslinking chemistry, and therefore elastic modulus, impacts the pressure at which ...
Kathryn E. Shaffer, Alex Q. Zhang, Mehdi Karimi, Ahmed Al Kindi, Linnaea D. Uliassi, Nemea S. Courelli, Julia J. Ong, Conor D. Pugsley, Andrew R. Rhode, Erik B. Watkins, Rebecca J.L. Welbourn, Alexander Alexeev, Angela A. Pitenis   +12 more
wiley   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Magnetically targeted delivery through cartilage

AIP Advances, 2018
In this study, we have invented a method of delivering drugs deep into articular cartilage with shaped dynamic magnetic fields acting on small metallic magnetic nanoparticles with polyethylene glycol coating and average diameter of 30 nm.
Sahar Jafari, Lamar O. Mair, Sagar Chowdhury, Alek Nacev, Ryan Hilaman, Pavel Stepanov, James Baker-McKee, Said Ijanaten, Christian Koudelka, Bradley English, Pulkit Malik, Irving N. Weinberg   +11 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

An Implantable Optogenetics‐Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light‐Controlled Metabolic Reprogramming of Synovial Macrophages

Advanced Science, EarlyView.
An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu, Yaru Sun, Qi Lu, Yi Zhang, Jieruo Li, Huige Hou, Huajun Wang, Hui Tang, Yunsong Zhang, Xiaofei Zheng, Qingsong Mei   +10 more
wiley   +1 more source