Results 141 to 150 of about 2,326,263 (272)

A Living Multi‐Omics PDX Biobank of High‐Risk Sarcomas Reveals ecDNA‐Driven Oncogene Amplification in Osteosarcoma and Enables Preclinical Precision Oncology

Advanced Science, EarlyView.
A living multi‐omics sarcoma PDX biobank is enriched for high‐risk disease and preserves key patient tumor features at histopathological and molecular levels. Integrated profiling reveals ecDNA‐driven oncogene amplification in osteosarcoma and preferential retention of ecDNA during PDX evolution.
Weisong Zhao, Zhiwei Cheng, Kai Tian, Mengxiong Sun, Zhuoying Wang, Ming Jiao, Jens Luebeck, Kaiyuan Zhu, Xiao Zhang, Dongqing Zuo, Hongsheng Wang, Chongren Wang, Jiakang Shen, Xiaojun Ma, Gangyang Wang, Zongyi Wang, Jing Han, Kaiyuan Liu, Haoran Mu, Weiqi Ma, Yongyong Ren, Shibing Guo, Huangxin Tu, Lingfeng Yu, Yining Tao, Yu Lv, Hui Lu, Owen S. Chapman, Rishaan Kenkre, Lukas Chavez, Zhengdong Cai, Yuqin Yang, Wei Sun, Yafei Jiang, Yingqi Hua   +34 more
wiley   +1 more source

The Protective Activity of Apigenin Against Bone and Cartilage Diseases. [PDF]

Clin Interv Aging
Chen J, Liao X, Wu L.
europepmc   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Role of Tyrosine Kinase Inhibitors in Modulating Chondrocyte Activity and Cartilage Diseases. [PDF]

J Bone Metab
Hadid KA, Zaki MK, Alassaf FA, Abed MN.
europepmc   +1 more source

Runx2 and microRNA regulation in bone and cartilage diseases. [PDF]

Ann N Y Acad Sci, 2016
Zhao W, Zhang S, Wang B, Huang J, Lu WW, Chen D.   +5 more
europepmc   +1 more source

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo, Lidong Yang, Tiantian Xu, Dong Sun   +3 more
wiley   +1 more source

Targeting mitochondria in bone and cartilage diseases: A narrative review. [PDF]

Redox Biol
Mendelsohn DH, Walter N, Cheung WH, Wong RMY, Schönmehl R, Winter L, El Khassawna T, Heiss C, Brochhausen C, Rupp M.   +9 more
europepmc   +1 more source

Machine Learning‐Enabled Field Prediction and Inverse Design of Functionally Graded Materials Inspired by Tendon–Bone Enthesis

Advanced Intelligent Systems, EarlyView.
A mechanics‐informed machine learning framework enables mechanics field prediction and inverse design of tendon–bone enthesis‐inspired functionally graded materials that reduce stress concentration and failure risk. By coupling multiscale finite element modeling, convolutional field prediction, and kernel‐based inverse design, the study uncovers ...
Zhangke Yang, Zhaoxu Meng
wiley   +1 more source

THE TREATMENT OF DISEASES OF THE COSTAL CARTILAGES

Annals of Surgery, 1918
openaire   +3 more sources

A Molecular Chemical Perspective: Mitochondrial Dynamics Is Not a Bystander of Cartilage Diseases. [PDF]

ACS Pharmacol Transl Sci
Wu J, Zhou X, Xu X, Xie J.
europepmc   +1 more source