Results 141 to 150 of about 111,756 (251)

Computed Tomography‐Based Morphometric Analysis Reveals Intercondylar Notch Stenosis and Osteophytes Are Associated With Anterior Cruciate Ligament Injury

Arthroscopy, EarlyView.
Purpose To quantitatively assess intercondylar notch morphometrics using 3‐dimensional computed tomography reconstruction, evaluate their association with anterior cruciate ligament (ACL) injury in Asian populations, and investigate the prevalence of osteophytes in patients with ACL injury.
Xiaozhong Ma, WenMing Jiang, Chao Lu, Tongyue Ji, Su Yan, Heng Zhu, Xue He, Hao Shu, Lei Wang, Luning Sun   +9 more
wiley   +1 more source

Intra‐articular Orthobiologics Show Statistically but Not Clinically Meaningful Improvements Compared With Viscosupplementation in Knee Osteoarthritis: A Network Meta‐analysis of Randomized Controlled Trials

Arthroscopy, EarlyView.
Purpose To evaluate the comparative effectiveness of intra‐articular platelet‐rich plasma (PRP), stromal vascular fraction (SVF), bone marrow aspirate concentrate (BMAC), umbilical cord‐derived mesenchymal stem cell (UC‐MSC), and hyaluronic acid (HA) for pain relief and functional improvement in patients with knee osteoarthritis through network meta ...
Joo Hyung Han, Min Jung, Kwangho Chung, Hyun‐Soo Moon, Se‐Han Jung, Sung‐Hwan Kim   +5 more
wiley   +1 more source

Hip Arthroscopy in Adults Aged 40 or Older Produces Clinically Meaningful Symptom Improvement but Carries a Substantial Risk of Conversion to Total Hip Arthroplasty: A Systematic Review

Arthroscopy, EarlyView.
Purpose To report conversion rates to total hip arthroplasty (THA), patient‐reported outcome measures, and complication rates in adults aged ≥ 40 years undergoing hip arthroscopy since 2016. Methods MEDLINE, EMBASE, and PubMed were searched from January 2016 to March 2025, and pertinent data were abstracted from eligible studies according to the ...
Helena Son, Benjamin Blackman, Joshua Dworsky‐Fried, Dan Cohen, Yoan Bourgeault‐Gagnon, Axel Öhlin, Nicole Simunovic, Iqbal Multani, Tyler M. Hauer, Craig S. Mauro, Olufemi Ayeni   +10 more
wiley   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Dual Labral and Ligamentum Teres Reconstruction Achieves High Functional Outcomes and Arthroplasty‐Free Survivorship at 2 Years

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To evaluate the clinical outcomes and survivorship of hip arthroscopy with simultaneous labral and ligamentum teres (LT) reconstruction for the treatment of irreparable labral and LT tears, with a minimum follow‐up of 2 years. Methods Prospectively collected data were retrospectively reviewed for patients who underwent combined arthroscopic ...
Roger Quesada‐Jimenez, Krishi Rana, Matthew J. Strok, Ady H. Kahana‐Rojkind, Alexander K. Burt, Etan P. Sugarman, Benjamin G. Domb   +6 more
wiley   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Tissue‐Specific and Spatially Dependent Metabolic Signatures Perturbed by Injury in Male and Female Mice

Arthritis &Rheumatology, EarlyView.
Objective Osteoarthritis, the leading cause of disability worldwide, disproportionately affects women, yet sex remains an overlooked determinant. This disparity stems from sex‐specific differences in injury susceptibility—a major risk factor for disease.
Hope D. Welhaven, Avery H. Welfley, Priyanka P. Brahmachary, Mark Greenwood, Donald F. Smith, Brian Bothner, Ronald K. June   +6 more
wiley   +1 more source

CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post‐traumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine osteoarthritis (OA) models that vary in severity of pathology and rate of progression to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source

Tissue Damage in Rheumatoid Arthritis Is Genetically Linked to Low Peptidylglycine Alpha‐Amidating Monooxygenase Activity in Synovial Fibroblasts

Arthritis &Rheumatology, EarlyView.
Objective Both susceptibility to, and severity of, rheumatoid arthritis (RA) is associated with the rs26232 C allele. Our primary aim was to identify the biologic mechanism underlying this association. Methods Expression of surrounding genes was compared among rs26232 genotypes.
Kevin J. Sheridan, Emma R. Dorris, Maria Inês Pimenta, Jemma Falkov, Matthew Fisher, Sam Pledger, Hector Devey, Munitta Muthana, Denis C. Shields, Richard E. Mains, Betty A. Eipper, Christopher D. Buckley, Anthony G. Wilson   +12 more
wiley   +1 more source

Functional Impact of Structural Damage in Psoriatic Arthritis: Insights from a Prospective Cohort Study

Arthritis &Rheumatology, EarlyView.
Objective To examine the association between radiographic structural damage and physical function (PF) in psoriatic arthritis (PsA). Methods Data were analyzed from a large longitudinal PsA cohort. PF was measured using the Health Assessment Questionnaire (HAQ, 0–3) and Short Form‐36 PF subscale (SF‐36, 0–100); radiographic joint damage was measured ...
Pankti Mehta, Shangyi Gao, Virginia Carrizo Abarza, Fadi Kharouf, Daniel Pereira, Richard J. Cook, Dafna D. Gladman, Vinod Chandran, Denis Poddubnyy   +8 more
wiley   +1 more source