Results 51 to 60 of about 108,199 (280)
Advanced Functional Materials, EarlyView.Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana +2 more
wiley +1 more source
Advanced Functional Materials, EarlyView.This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer +7 more
wiley +1 more source
iCartiGD: the Integrated Cartilage Gene Database
BMC Genetics, 2007 Background Diseases of cartilage, such as arthritis and degenerative disc disease, affect the majority of the general population, particularly with ageing.
Sham Pak +10 more
doaj +1 more source
3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research
Advanced Functional Materials, EarlyView.A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram +5 more
wiley +1 more source
Cell Transplantation, 2019 Regeneration of articular cartilage is of great interest in cartilage tissue engineering since articular cartilage has a low regenerative capacity. Due to the difficulty in obtaining healthy cartilage for transplantation, there is a need to develop an ...
Yeri Alice Rim, Yoojun Nam, Ji Hyeon Ju
doaj +1 more source
Cartilage Adjacent Subchondral Bone in Ageing and Disease as a Diagnostic and Therapeutic Target [PDF]
, 2021 Shahed Taheri
openalex +1 more source
Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix
Advanced Functional Materials, EarlyView.Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt +2 more
wiley +1 more source
Ionic Control of Microstructure and Lubrication in Charged, Physically Cross‐Linked Hydrogels
Advanced Functional Materials, EarlyView.Here, charged, physically cross‐linked poly(methacrylamide‐co‐methacrylic acid) hydrogels stabilized by a short‐range attractive, long‐range repulsive potential is investigated. This work uncovers how salt addition alters not only swelling, but also the microstructure and dynamics, near‐surface stiffness and charge, and ultimately, its lubricity. Salts
Alexander Deptula +1 more
wiley +1 more source
Role of Epigenomics in Bone and Cartilage Disease [PDF]
Journal of Bone and Mineral Research, 2019 ABSTRACT Phenotypic variation in skeletal traits and diseases is the product of genetic and environmental factors. Epigenetic mechanisms include information-containing factors, other than DNA sequence, that cause stable changes in gene expression and are maintained during cell divisions.
Joyce B. J. van Meurs +3 more
openalex +4 more sources
Frontiers in Bioengineering and BiotechnologyFocal cartilage defects are common in youth and older adults, cause significant morbidity and constitute a major risk factor for developing osteoarthritis (OA).
T. Mark Campbell +5 more
doaj +1 more source