Results 51 to 60 of about 9,103,182 (195)
Metabolism of Cartilage Proteoglycans in Health and Disease [PDF]
BioMed Research International, 2014 Cartilage proteoglycans are extracellular macromolecules with complex structure, composed of a core protein onto which a variable number of glycosaminoglycan chains are attached. Their biosynthesis at the glycosaminoglycan level involves a great number of sugar transferases well-orchestrated in Golgi apparatus.
openaire +3 more sources
Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons [PDF]
Journal of Experimental Medicine Aug 2019, 216 (8) 1904-1924, 2019 Rheumatoid arthritis-associated joint pain is frequently observed independent of disease activity, suggesting unidentified pain mechanisms. We demonstrate that antibodies binding to cartilage, specific for collagen type II (CII) or cartilage oligomeric matrix protein (COMP), elicit mechanical hypersensitivity in mice, uncoupled from visual ...
arxiv +1 more source
Cartilage, 2021 Purpose of Review Mitochondria are recognized to be one of the most important organelles in chondrocytes for their role in triphosphate (ATP) generation through aerobic phosphorylation.
Shiyi Kan +4 more
semanticscholar +1 more source
microRNAs in Cartilage Development, Homeostasis, and Disease [PDF]
Current Osteoporosis Reports, 2014 microRNAs (miRNAs) regulate gene expression mainly at the posttranscriptional level. Many different miRNAs are expressed in chondrocytes, and each individual miRNA can regulate hundreds of target genes, creating a complex gene regulatory network.
Fatemeh Mirzamohammadi +2 more
openaire +3 more sources
Structural Origins of Cartilage Shear Mechanics [PDF]
arXiv, 2021 Healthy cartilage is a remarkable tissue, able to withstand tens of millions of loading cycles with minimal damage. While much is known about the structural origins of its compressive mechanics, how composition determines its mechanical behavior in shear, a major mode of failure, is poorly understood.
arxiv
An Update on the Role of Leptin in the Immuno-Metabolism of Cartilage
International Journal of Molecular Sciences, 2021 Since its discovery in 1994, leptin has been considered as an adipokine with pleiotropic effects. In this review, we summarize the actual information about the impact of this hormone on cartilage metabolism and pathology. Leptin signalling depends on the
Alfonso Cordero-Barreal +11 more
semanticscholar +1 more source
Investigation of the Effect of Selected Piperazine-2,5-Diones on Cartilage-Related Cells
Chemistry Proceedings, 2021 Various chronic inflammatory diseases have become a problem, especially in the Western world. Whether it concerns inflammation of visceral organs, joints, bones, etc., it is always a physiological reaction of the body, which always tries to eradicate ...
Josef Jampilek, Jan Hosek, Pavel Bobal
doaj +1 more source
Multi-Channel Volumetric Neural Network for Knee Cartilage Segmentation in Cone-beam CT [PDF]
, 2019 Analyzing knee cartilage thickness and strain under load can help to further the understanding of the effects of diseases like Osteoarthritis. A precise segmentation of the cartilage is a necessary prerequisite for this analysis. This segmentation task has mainly been addressed in Magnetic Resonance Imaging, and was rarely investigated on contrast ...
arxiv +1 more source
Liposomic lubricants suppress shear-stress induced inflammatory gene regulation in the joint in vivo [PDF]
arXiv, 2023 Osteoarthritis (OA) is a widespread, debilitating joint disease associated with articular cartilage degradation. It is driven via mechano-inflammatory catabolic pathways, presumed up-regulated due to increased shear stress on the cartilage-embedded chondrocytes, that lead to tissue degeneration.
arxiv
Knee Cartilage Defect Assessment by Graph Representation and Surface Convolution [PDF]
arXiv, 2022 Knee osteoarthritis (OA) is the most common osteoarthritis and a leading cause of disability. Cartilage defects are regarded as major manifestations of knee OA, which are visible by magnetic resonance imaging (MRI). Thus early detection and assessment for knee cartilage defects are important for protecting patients from knee OA.
arxiv