Results 31 to 40 of about 2,326,263 (272)

Effect on mechanical properties of articular cartilage through inflammatory response of synoviocytes under tissue and cell co-culture model

Nihon Kikai Gakkai ronbunshu, 2014
Articular cartilage has a poor ability to regenerate itself, therefore it is important to establish the treatment methodologies for cartilage diseases such as osteoarthritis (OA) or rheumatoid arthritis (RA).
Shinya YAMAZAKI, Shogo MIYATA
doaj   +1 more source

Histone Modifications and Chondrocyte Fate: Regulation and Therapeutic Implications

Frontiers in Cell and Developmental Biology, 2021
The involvement of histone modifications in cartilage development, pathology and regeneration is becoming increasingly evident. Understanding the molecular mechanisms and consequences of histone modification enzymes in cartilage development, homeostasis ...
Chao Wan, Chao Wan, Chao Wan, Fengjie Zhang, Fengjie Zhang, Fengjie Zhang, Hanyu Yao, Hanyu Yao, Hanyu Yao, Haitao Li, Rocky S. Tuan, Rocky S. Tuan, Rocky S. Tuan   +12 more
doaj   +1 more source

lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration

Stem Cell Research & Therapy, 2019
With the increasing incidence of cartilage-related diseases such as osteoarthritis (OA) and intervertebral disc degeneration (IDD), heavier financial and social burdens need to be faced.
Jian Zhu, Wei Yu, Yitian Wang, Kaishun Xia, Yuluan Huang, Ankai Xu, Qixin Chen, Bing Liu, Huimin Tao, Fangcai Li, Chengzhen Liang   +10 more
doaj   +1 more source

Computational modelling of fluid load support in articular cartilage [PDF]

, 2013
Natural articular cartilage is known to be an excellent bearing material with very low friction coefficient and wear rate. Theoretical and experimental studies have demonstrated that the interstitial fluid of cartilage is pressurized considerably ...
An, Shuqiang
core   +6 more sources

Roles of the calcified cartilage layer and its tissue engineering reconstruction in osteoarthritis treatment

Frontiers in Bioengineering and Biotechnology, 2022
Sandwiched between articular cartilage and subchondral bone, the calcified cartilage layer (CCL) takes on both biomechanical and biochemical functions in joint development and ordinary activities.
Weiyang Wang, Weiyang Wang, Ruixi Ye, Ruixi Ye, Wenqing Xie, Wenqing Xie, Yueyao Zhang, Yueyao Zhang, Senbo An, Yusheng Li, Yusheng Li, Yang Zhou   +11 more
doaj   +1 more source

Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilage

, 2008
Osteoarthritis (OA) is generally a disease of the elderly population, but can occur in young patients in exceptional cases. This study compares the cellular and epigenetic features of primary old-age OA with those of secondary OA in a 23-year old patient
da Silva, M.A., Roach, H.I., Yamada, N., Clarke, N.M.   +3 more
core   +1 more source

microRNAs in Cartilage Development, Homeostasis, and Disease [PDF]

Current Osteoporosis Reports, 2014
microRNAs (miRNAs) regulate gene expression mainly at the posttranscriptional level. Many different miRNAs are expressed in chondrocytes, and each individual miRNA can regulate hundreds of target genes, creating a complex gene regulatory network.
Fatemeh, Mirzamohammadi, Garyfallia, Papaioannou, Tatsuya, Kobayashi   +2 more
openaire   +2 more sources

Cartilage to bone transitions in health and disease [PDF]

Journal of Endocrinology, 2013
Aberrant redeployment of the ‘transient’ events responsible for bone development and postnatal longitudinal growth has been reported in some diseases in what is otherwise inherently ‘stable’ cartilage. Lessons may be learnt from the molecular mechanisms underpinning transient chondrocyte differentiation and function, and their application may better ...
Staines, Katherine, Pollard, Andrea Sophie, McGonnell, Imelda M, Farquharson, Colin; id_orcid 0000-0002-4970-4039, Pitsillides, Andrew Anthony   +4 more
openaire   +3 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Investigation of the Effect of Selected Piperazine-2,5-Diones on Cartilage-Related Cells

Chemistry Proceedings, 2021
Various chronic inflammatory diseases have become a problem, especially in the Western world. Whether it concerns inflammation of visceral organs, joints, bones, etc., it is always a physiological reaction of the body, which always tries to eradicate ...
Josef Jampilek, Jan Hosek, Pavel Bobal
doaj   +1 more source