Results 31 to 40 of about 111,756 (251)
Cartilage homeostasis in health and rheumatic diseases [PDF]
Arthritis Research & Therapy, 2009 As the cellular component of articular cartilage, chondrocytes are responsible for maintaining in a low-turnover state the unique composition and organization of the matrix that was determined during embryonic and postnatal development. In joint diseases, cartilage homeostasis is disrupted by mechanisms that are driven by combinations of biological ...
Goldring, Mary B, Marcu, Kenneth B
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microRNAs in Cartilage Development, Homeostasis, and Disease [PDF]
Current Osteoporosis Reports, 2014 microRNAs (miRNAs) regulate gene expression mainly at the posttranscriptional level. Many different miRNAs are expressed in chondrocytes, and each individual miRNA can regulate hundreds of target genes, creating a complex gene regulatory network.
Fatemeh, Mirzamohammadi +2 more
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Cartilage to bone transitions in health and disease [PDF]
Journal of Endocrinology, 2013 Aberrant redeployment of the ‘transient’ events responsible for bone development and postnatal longitudinal growth has been reported in some diseases in what is otherwise inherently ‘stable’ cartilage. Lessons may be learnt from the molecular mechanisms underpinning transient chondrocyte differentiation and function, and their application may better ...
Staines, Katherine +4 more
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Investigation of the Effect of Selected Piperazine-2,5-Diones on Cartilage-Related Cells
Chemistry Proceedings, 2021 Various chronic inflammatory diseases have become a problem, especially in the Western world. Whether it concerns inflammation of visceral organs, joints, bones, etc., it is always a physiological reaction of the body, which always tries to eradicate ...
Josef Jampilek, Jan Hosek, Pavel Bobal
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Hemophilic arthropathy remains the leading morbidity in hemophilia despite modern prophylaxis, and early joint damage may be missed by routine exams. This study explored T2* MRI as a noninvasive biomarker of hemosiderin deposition in pediatric hemophilia.
Jessica Garcia +6 more
wiley +1 more source
Materials Today Bio, 2022 While joint arthroplasty remains nowadays the most popular option available to repair chronically degenerated osteoarthritic joints, possibilities are recently emerging for regeneration of damaged cartilage rather than its replacement with artificial ...
Giuseppe Pezzotti +6 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Animal Models and Experimental MedicineBackground Native cartilage has low capacity for regeneration because it has very few progenitor cells. Human umbilical cord blood‐derived mesenchymal stem cells (hUCB‐MSCs) and human umbilical cord‐derived MSCs (hUC‐MSCs) have been employed as promising
Xingfu Li, Zhenhan Deng, Wei Lu
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Mesenchymal stem cells for cartilage regeneration
Journal of Tissue Engineering, 2020 Cartilage injuries are typically caused by trauma, chronic overload, and autoimmune diseases. Owing to the avascular structure and low metabolic activities of chondrocytes, cartilage generally does not self-repair following an injury. Currently, clinical
Hanxiang Le +5 more
doaj +1 more source
Cartilage tissue engineering for degenerative joint disease☆ [PDF]
Advanced Drug Delivery Reviews, 2006 Pain in the joint is often due to cartilage degeneration and represents a serious medical problem affecting people of all ages. Although many, mostly surgical techniques, are currently employed to treat cartilage lesions, none has given satisfactory results in the long term.
Nesic, Dobrila +5 more
openaire +4 more sources