Results 51 to 60 of about 2,326,263 (272)

Direct Visualisation of the Depth-Dependent Mechanical Properties of Full-Thickness Articular Cartilage. [PDF]

, 2012
The structural anisotropy of articular cartilage controls its deformation response. As proteoglycans and collagen vary with depth, simple uniaxial compression results in inhomogeneous deformation with distinct depth-dependent mechanical properties ...
Szarko, M, Xia, Y
core   +1 more source

Development of a Disease Activity Index for the Assessment of VEXAS Syndrome (VEXAS‐DAI)

Arthritis Care &Research, EarlyView.
Objective Vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic syndrome (VEXAS) syndrome is characterized by a complex spectrum of inflammatory and hematologic manifestations. Clinical research to identify effective therapies is urgently needed but is hindered by the lack of validated outcome measures.
Kevin Byram, Heřman Mann, Danielle Hammond, Onima Chowdhury, Sinisa Savic, Yohei Kirino, Carmelo Gurnari, Maël Heiblig, Thibault Comont, Arsène Mekinian, Mrinal M. Patnaik, Lachelle D. Weeks, Gary Ho, Adam Al‐Hakim, Scott Goldberg, Marcela A. Ferrada, Sophie Georgin‐Lavialle, Peter C. Grayson, Emma M. Groarke, Bhavisha Patel, Megan Sullivan, Sarah A. Buckley, Bryan G. Harder, Raman Garcha, David B. Beck, Matthew J. Koster   +25 more
wiley   +1 more source

Bioreactor based engineering of large-scale human cartilage grafts for joint resurfacing [PDF]

, 2010
Apart from partial or total joint replacement, no surgical procedure is currently available to treat large and deep cartilage defects associated with advanced diseases such as osteoarthritis.
Dieter Wirz, Longinotti, Cristina, Lacroix, Damien, Rosaria Santoro, Olivares, Andy L., Gerben Brans, Damien Lacroix, Wendt, David, Wirz, Dieter, Santoro, Rosaria, Martin, Ivan, Ivan Martin, Cristina Longinotti, David Wendt, Andy L. Olivares, Brans, Gerben   +15 more
core   +1 more source

Biomechanical Influence of Cartilage Homeostasis in Health and Disease [PDF]

Arthritis, 2011
There is an urgent demand for long term solutions to improve osteoarthritis treatments in the ageing population. There are drugs that control the pain but none that stop the progression of the disease in a safe and efficient way. Increased intervention efforts, augmented by early diagnosis and integrated biophysical therapies are therefore needed ...
D. L. Bader, D. M. Salter, T. T. Chowdhury   +2 more
openaire   +4 more sources

Polysaccharide-based hydrogels for cartilage regeneration

Frontiers in Cell and Developmental Biology
Cartilage defect is one of the common tissue defect clinical diseases and may finally lead to osteoarthritis (OA) which threat patients’ physical and psychological health.
Ning Chen, Sidi Li, Congrui Miao, Qin Zhao, Jinlei Dong, Lianxin Li, Ci Li   +6 more
doaj   +1 more source

Industrial application of fish cartilaginous tissues

Current Research in Food Science, 2022
Cartilage is primarily composed of proteoglycans and collagen. Bioactive compounds derived from animal cartilage, such as chondroitin sulfate and type II collagen, have multiple bioactivities and are incorporated in popular health products.
Wen Li, Kazuhiro Ura, Yasuaki Takagi
doaj   +1 more source

Clinical Validation of Artificial Intelligence (AI)‐based Cartilage Segmentation Predicting Knee Replacement

Arthritis Care &Research, Accepted Article.
Objective For cartilage morphology to serve as a scalable endpoint in clinical trials, analyses should be performed automatically without human interaction. To clinically validate artificial intelligence (AI)‐based analysis, we studied cartilage loss from MRI prior to knee replacement.
Felix Eckstein, David J. Hunter, C. Kent Kwoh, Wolfgang Wirth   +3 more
wiley   +1 more source

Estimating the prevalence and incidence of symptomatic hand OA in the Netherlands using primary care electronic health records.

Arthritis Care &Research, Accepted Article.
Objective This study estimated the incidence and prevalence of symptomatic hand osteoarthritis (OA) in the Dutch population using a validated algorithm that integrates free‐text data from primary care electronic health records (EHRs). Methods This retrospective cohort study used the Integrated Primary Care Information (IPCI) database, including EHRs ...
Onur Kaya, Jacoline van den Driest, Laura Struik, Margreet Kloppenburg, Ruud Selles, Daniel Prieto Alhambra, Sita Bierma‐Zeinstra, Dieuwke Schiphof   +7 more
wiley   +1 more source

From cells to organs: progress and potential in cartilaginous organoids research

Journal of Translational Medicine, 2023
While cartilage tissue engineering has significantly improved the speed and quality of cartilage regeneration, the underlying metabolic mechanisms are complex, making research in this area lengthy and challenging.
Xiao-he Wang, Ning Liu, Hui Zhang, Zong-sheng Yin, Zhen-Gang Zha   +4 more
doaj   +1 more source

Water loss and defects dependent strength and ductility of articular cartilage

Journal of Materials Research and Technology, 2022
Water loss and surface defects of articular cartilage extremely aggravate the risk of osteoarticular diseases. The effects of water content and surface defects on the mechanical properties of cartilage need to be taken into further account.
Jize Liu, Shuting Xu, Zhichao Ma, Yue Jiang, Hongwei Zhao, Luquan Ren   +5 more
doaj   +1 more source