Results 11 to 20 of about 192,550 (253)

MSC-EV therapy for bone/cartilage diseases [PDF]

Bone Reports, 2022
Mesenchymal stromal cells (MSCs) have been utilized in cell therapy for various diseases. Recent studies have demonstrated that extracellular vesicles (EVs) released by MSCs play an important role in their therapeutic activities. EVs contain a variety of
Joe Kodama, Kevin J. Wilkinson, Satoru Otsuru   +2 more
doaj   +2 more sources

A novel therapeutic strategy for cartilage diseases based on lipid nanoparticle-RNAi delivery system [PDF]

International Journal of Nanomedicine, 2018
Shaowei Wang,1 Xiaochun Wei,1 Xiaojuan Sun,1 Chongwei Chen,1 Jingming Zhou,2 Ge Zhang,3 Heng Wu,3 Baosheng Guo,3 Lei Wei1,2 1Department of Orthopaedics, The 2nd Hospital of Shanxi Medical University, Taiyuan, Shanxi, China; 2Department of Orthopaedics ...
Wang S, Wei X, Sun X, Chen C, Zhou J, Zhang G, Wu H, Guo B, Wei L   +8 more
doaj   +2 more sources

Stem Cells in Cartilage Diseases and Repair 2018 [PDF]

Stem Cells International, 2018
Jianying Zhang, Shiwu Dong, Wesley N. Sivak, Hui Bin Sun, Peng Chang   +4 more
doaj   +2 more sources

Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes. [PDF]

, 2017
Background: MicroRNAs (miRNAs) in circulation have emerged as promising biomarkers. In this study, we aimed to identify a circulating miRNA signature for osteoarthritis (OA) patients and in combination with bioinformatics analysis to evaluate the utility
A Brazma, A Nan, A Okuhara, A Turchinovich, B Aryal, B Mayr, B Sharif, B Zhang, BM Bolstad, BM Kuhn, BM Mayr, C Beyer, C Chen, C Guay, C Taurino, CL Andersen, D Dlouha, D Iliopoulos, D Zhang, DT Felson, F Kostopoulou, FE Nicolas, G Dennis Jr, G Li, G Tardif, GD Miles, GR Sondag, GS Lien, H Causton, JB van Meurs, JD Storey, JD Storey, KC Vickers, L Qi, M Cross, M Parrizas, MB Goldring, MC Hochberg, MD Paraskevopoulou, MP Gantier, OF Laterza, Q Zhuo, R Gernapudi, RF Loeser, RI Gregory, S Kluzek, S Kumar, S Miyaki, T Thomou, TA Karlsen, VM Borgonio Cuadra, W Cleveland, WM Reichmann, X Chen, X Chen, X Tan, X Wang, Y Klipper-Aurbach, Y Zhang, YH Li   +59 more
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Strategies for Articular Cartilage Repair and Regeneration

Frontiers in Bioengineering and Biotechnology, 2021
Articular cartilage is an avascular tissue, with limited ability to repair and self-renew. Defects in articular cartilage can induce debilitating degenerative joint diseases such as osteoarthritis.
Yanxi Liu, Karan M. Shah, Jian Luo, Jian Luo   +3 more
doaj   +1 more source

c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. [PDF]

, 2012
The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands ...
Firestein, Gary S, Guma, Monica
core   +1 more source

Genome engineering of stem cells for autonomously regulated, closed-loop delivery of biologic drugs [PDF]

, 2017
Chronic inflammatory diseases such as arthritis are characterized by dysregulated responses to pro-inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor α (TNF-α).
Brunger, Jonathan M, Gersbach, Charles A, Guilak, Farshid, Willard, Vincent P, Zutshi, Ananya   +4 more
core   +3 more sources

A new type of lordosis and vertebral body compression in Gilthead seabream, Sparus aurata Linnaeus, 1758: aetiology, anatomy and consequences for survival [PDF]

, 2013
A new type of vertebral malformation is described, consisting of deformed cartilaginous neural and haemal processes and the compression and fusion of vertebral bodies. The malformation is designated as haemal vertebral compression and fusion (haemal VCF).
Georgiou, AN, Koumoundouros, G, Loizides, M, Somarakis, S, Witten, Paul   +4 more
core   +2 more sources

Use of Exogenous Hyaluronic Acid for the Treatment of Patellar Chondropathy– A Six-Month Randomized Controlled Trial [PDF]

Revista Brasileira de Ortopedia
Objective To evaluate the clinical and radiological benefits of intra-articular exogenous hyaluronic acid for the treatment of chondral patellar injury. Method Randomized clinical trial with 70 patients divided into 2 groups: those submitted to physical
Diego Costa Astur, Felipe Berteli Angelini, Marcelo Abdulchlek Santos, Gustavo Gonçalves Arliani, Paulo Santoro Belangero, Moisés Cohen   +5 more
doaj   +3 more sources

Sex-dependent variation in cartilage adaptation: from degeneration to regeneration

Biology of Sex Differences, 2023
Highlights Evidence indicates males and females respond differently to cartilage degeneration and regeneration. Few review articles available provide comprehensive information referencing clinical and laboratory research.
Jhanvee Patel, Song Chen, Torey Katzmeyer, Yixuan Amy Pei, Ming Pei   +4 more
doaj   +1 more source