Results 11 to 20 of about 2,326,263 (272)
Sprifermin: Effects on Cartilage Homeostasis and Therapeutic Prospects in Cartilage-Related Diseases [PDF]
Frontiers in Cell and Developmental Biology, 2021 When suffering from osteoarthritis (OA), articular cartilage homeostasis is out of balance and the living quality declines. The treatment of knee OA has always been an unsolved problem in the world. At present, symptomatic treatment is mainly adopted for
Zongmian Song +7 more
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Contact mechanics modelling of articular cartilage and applications [PDF]
, 2006 Osteoarthritis (OA) is a degenerative disease of articular cartilage. The normal cartilage is known to be an excellent bearing material with remarkable lubricating properties and very low frictional co-efficient and wear and generally survives the ...
Pawaskar, Sainath Shrikant
core +6 more sources
The Effects of Crocin on Bone and Cartilage Diseases. [PDF]
Front Pharmacol, 2021 Crocin, the main biologically active carotenoid of saffron, generally is derived from the dried trifid stigma of Crocus sativus L. Many studies have demonstrated that crocin has several therapeutic effects on biological systems through its anti-oxidant and anti-inflammatory properties.
Vafaei S +3 more
europepmc +5 more sources
The effect of mechanical stress on the stiffness of articular cartilage and its role in the aetiology of osteoarthrosis [PDF]
, 1988 Although a substantial amount is known about the pathogenesis of osteoarthrosis, its aetiology and in particular the role that mechanical factors play, remains unclear.
Swann, Anthony Charles
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Joint contact modelling of articular cartilage in synovial joints [PDF]
, 2010 Hip joint is one of the important load bearing joints and has been extensively studied to investigate contact mechanics and tribology. It has known to experience high contact forces and stresses.
Pawaskar, Sainath Shrikant
core +7 more sources
Cartilage of I-Cell Disease [PDF]
Pediatric Research, 1981 Biochemical analysis and morphologic observation of the iliac crest cartilage from 8-year-old girl with I-cell disease were performed. Instead of hypertrophic change of chondrocytes in the zone of cartilage-bone junction, there were small atrophic cells having many inclusion bodies accumulated with lamellar materials.
H, Nogami +3 more
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Osteochondral explant for cartilage research: a promising tool linking bench to bedside [PDF]
European Cells & Materials, 2022 Diarthrodial joint diseases, affecting hundreds of millions of people worldwide, mainly include osteoarthritis and cartilage injuries. No consensus on joint disease models has been achieved so far owing to the complex aetiologies, pathophysiological ...
KH Li +5 more
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BAP31 Drives Cartilage Calcification through Disruption of Autophagosome-Lysosome Fusion in Osteoarthritis. [PDF]
Adv Sci (Weinh)Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Xu ZH +13 more
europepmc +2 more sources
BioTechniques, 2014 Micromass cultures of primary embryonic limb mesenchyme are a valuable model system for studying cartilage formation in vitro. However, high efficiency introduction of plasmid DNA into this hard-to-transfect cell type typically results in considerable ...
Brent E. Bobick +2 more
doaj +1 more source
Melatonin: Effects on Cartilage Homeostasis and Therapeutic Prospects in Cartilage-related Diseases [PDF]
Aging and disease, 2021 Cartilage is a relatively simple connective tissue that plays a variety of roles in the human body, including joint support and protection, load bearing of the intervertebral discs, joint lubrication, formation of the external structure of the ears and nose and support of the trachea.
Xie, Wen-qing +7 more
openaire +2 more sources