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The role of TGF-β2 in cartilage development and diseases
Bone and Joint Research, 2021 Transforming growth factor-beta2 (TGF-β2) is recognized as a versatile cytokine that plays a vital role in regulation of joint development, homeostasis, and diseases, but its role as a biological mechanism is understood far less than that of its ...
Qingxuan Wang, Jing Xie
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Gels, 2021 Joint diseases that mainly lead to articular cartilage injury with prolonged severe pain as well as dysfunction have remained unexplained for many years.
Xu Han, Yue Shan, Jinfeng Liao
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Sprifermin: Effects on Cartilage Homeostasis and Therapeutic Prospects in Cartilage-Related Diseases
Frontiers in Cell and Developmental Biology, 2021 When suffering from osteoarthritis (OA), articular cartilage homeostasis is out of balance and the living quality declines. The treatment of knee OA has always been an unsolved problem in the world. At present, symptomatic treatment is mainly adopted for
Yusheng Li, Guowei Shang, Songfeng Chen
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Cartilage organoids for cartilage development and cartilage-associated disease modeling
Frontiers in Cell and Developmental Biology, 2023 Cartilage organoids have emerged as powerful modelling technology for recapitulation of joint embryonic events, and cartilage regeneration, as well as pathophysiology of cartilage-associated diseases.
Weiping Lin +8 more
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Exercise improves subchondral bone microenvironment through regulating bone-cartilage crosstalk
Frontiers in Endocrinology, 2023 Articular cartilage degeneration has been proved to cause a variety of joint diseases, among which osteoarthritis is the most typical. Osteoarthritis is characterized by articular cartilage degeneration and persistent pain, which affects the quality of ...
Shihua Zhang +9 more
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Osteochondral explant for cartilage research: a promising tool linking bench to bedside [PDF]
European Cells & Materials, 2022 Diarthrodial joint diseases, affecting hundreds of millions of people worldwide, mainly include osteoarthritis and cartilage injuries. No consensus on joint disease models has been achieved so far owing to the complex aetiologies, pathophysiological ...
KH Li +5 more
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The protective activity of genistein against bone and cartilage diseases
Frontiers in Pharmacology, 2022 Genistein, a natural isoflavone rich in soybean and leguminous plants, has been shown various biological effects, such as anti-inflammation, anti-oxidation, anti-cancer, and bone/cartilage protection.
Zhenyu Wu, Zhenyu Wu, Luying Liu
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The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis. [PDF]
, 2013 Osteoarthritis (OA) is a degenerative disease that affects various tissues surrounding joints such as articular cartilage, subchondral bone, synovial membrane, and ligaments.
Maldonado, Maricela, Nam, Jin
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BioTechniques, 2014 Micromass cultures of primary embryonic limb mesenchyme are a valuable model system for studying cartilage formation in vitro. However, high efficiency introduction of plasmid DNA into this hard-to-transfect cell type typically results in considerable ...
Brent E. Bobick +2 more
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The regulatory activities of MALAT1 in the development of bone and cartilage diseases
Frontiers in Endocrinology, 2022 Long non-coding RNAs (lncRNAs) have been comprehensively implicated in various cellular functions by mediating transcriptional or post-transcriptional activities.
Di Zhang, Jinhua Xue, Fang Peng
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