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Cartilage organoids for cartilage development and cartilage-associated disease modeling
Frontiers in Cell and Developmental Biology, 2023 Cartilage organoids have emerged as powerful modelling technology for recapitulation of joint embryonic events, and cartilage regeneration, as well as pathophysiology of cartilage-associated diseases.
Weiping Lin +8 more
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Matrix Biol, 2018 Hyaline cartilages, fibrocartilages and elastic cartilages play multiple roles in the human body including bearing loads in articular joints and intervertebral discs, providing joint lubrication, forming the external ears and nose, supporting the trachea, and forming the long bones during development and growth.
Krishnan Y, Grodzinsky AJ.
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The protective activity of genistein against bone and cartilage diseases [PDF]
Frontiers in Pharmacology, 2022 Genistein, a natural isoflavone rich in soybean and leguminous plants, has been shown various biological effects, such as anti-inflammation, anti-oxidation, anti-cancer, and bone/cartilage protection.
Zhenyu Wu, Zhenyu Wu, Luying Liu
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The regulatory activities of MALAT1 in the development of bone and cartilage diseases [PDF]
Frontiers in Endocrinology, 2022 Long non-coding RNAs (lncRNAs) have been comprehensively implicated in various cellular functions by mediating transcriptional or post-transcriptional activities.
Di Zhang, Jinhua Xue, Fang Peng
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MSC-EV therapy for bone/cartilage diseases [PDF]
Bone Reports, 2022 Mesenchymal stromal cells (MSCs) have been utilized in cell therapy for various diseases. Recent studies have demonstrated that extracellular vesicles (EVs) released by MSCs play an important role in their therapeutic activities. EVs contain a variety of
Joe Kodama +2 more
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The role of TGF-β2 in cartilage development and diseases
Bone & Joint Research, 2021 Transforming growth factor-beta2 (TGF-β2) is recognized as a versatile cytokine that plays a vital role in regulation of joint development, homeostasis, and diseases, but its role as a biological mechanism is understood far less than that of its ...
Mengmeng Duan +3 more
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A novel therapeutic strategy for cartilage diseases based on lipid nanoparticle-RNAi delivery system [PDF]
International Journal of Nanomedicine, 2018 Shaowei Wang,1 Xiaochun Wei,1 Xiaojuan Sun,1 Chongwei Chen,1 Jingming Zhou,2 Ge Zhang,3 Heng Wu,3 Baosheng Guo,3 Lei Wei1,2 1Department of Orthopaedics, The 2nd Hospital of Shanxi Medical University, Taiyuan, Shanxi, China; 2Department of Orthopaedics ...
Wang S +8 more
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Gels, 2021 Joint diseases that mainly lead to articular cartilage injury with prolonged severe pain as well as dysfunction have remained unexplained for many years.
Xu Han +4 more
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Stem Cells in Cartilage Diseases and Repair 2018 [PDF]
Stem Cells International, 2018 Jianying Zhang +4 more
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Exercise improves subchondral bone microenvironment through regulating bone-cartilage crosstalk
Frontiers in Endocrinology, 2023 Articular cartilage degeneration has been proved to cause a variety of joint diseases, among which osteoarthritis is the most typical. Osteoarthritis is characterized by articular cartilage degeneration and persistent pain, which affects the quality of ...
Shihua Zhang +9 more
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