Results 21 to 30 of about 116,755 (297)

Copper-Containing Alloy as Immunoregulatory Material in Bone Regeneration via Mitochondrial Oxidative Stress

Frontiers in Bioengineering and Biotechnology, 2021
In the mammalian skeletal system, osteogenesis and angiogenesis are closely linked by type H vessels during bone regeneration and repair. Our previous studies confirmed the promotion of these processes by copper-containing metal (CCM) in vitro and in ...
Daorong Xu, Daorong Xu, Jikun Qian, Jikun Qian, Xin Guan, Xin Guan, Ling Ren, Kaifan Yang, Kaifan Yang, Xuan Huang, Shuyuan Zhang, Yu Chai, Yu Chai, Xiaohu Wu, Xiaohu Wu, Hangtian Wu, Hangtian Wu, Xianrong Zhang, Xianrong Zhang, Ke Yang, Bin Yu, Bin Yu   +21 more
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Osteoarthritis as a disease of the cartilage pericellular matrix [PDF]

Matrix Biology, 2018
Osteoarthritis is a painful joint disease characterized by progressive degeneration of the articular cartilage as well as associated changes to the subchondral bone, synovium, and surrounding joint tissues. While the effects of osteoarthritis on the cartilage extracellular matrix (ECM) have been well recognized, it is now becoming apparent that in many
Guilak, F., Nims, R.J., Dicks, A., Wu, C.L., Meulenbelt, I.   +4 more
openaire   +3 more sources

SOX9 in cartilage development and disease

Current Opinion in Cell Biology, 2019
SOX9 is a pivotal transcription factor in chondrocytes, a lineage essential in skeletogenesis. Its mandatory role in transactivating many cartilage-specific genes is well established, whereas its pioneer role in lineage specification, which along with transactivation defines master transcription factors, remains to be better defined.
Véronique, Lefebvre, Marco, Angelozzi, Abdul, Haseeb   +2 more
openaire   +3 more sources

Bioreactor based engineering of large-scale human cartilage grafts for joint resurfacing [PDF]

, 2010
Apart from partial or total joint replacement, no surgical procedure is currently available to treat large and deep cartilage defects associated with advanced diseases such as osteoarthritis.
Dieter Wirz, Longinotti, Cristina, Lacroix, Damien, Rosaria Santoro, Olivares, Andy L., Gerben Brans, Damien Lacroix, Wendt, David, Wirz, Dieter, Santoro, Rosaria, Martin, Ivan, Ivan Martin, Cristina Longinotti, David Wendt, Andy L. Olivares, Brans, Gerben   +15 more
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Effects of the Leptin-Mediated MAPK/ERK Signaling Pathway on Collagen II Expression in Knee Cartilage of Newborn Male Mice from Obese Maternal Offspring

Biomolecules, 2022
Epidemiological data suggest that various noncommunicable diseases develop as a result of altered maternal metabolic and physiological status due to exposure to several adverse factors during pregnancy. However, evidence for intrauterine exposure factors
Wenji Wang, Jialing Zhang, Yu Huo, Yuanzheng Zheng, Yonghao Gui   +4 more
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Postnatal development of depth-dependent collagen density in ovine articular cartilage [PDF]

, 2010
Articular cartilage (AC) is the layer of tissue that covers the articulating ends of the bones in diarthrodial joints. Adult AC is characterised by a depth-dependent composition and structure of the extracellular matrix that results in depth-dependent ...
Kranenbarg, S., Leeuwen, J.L., van, Barend van Lagen, Turnhout, van, M.C.; id_orcid, Han Zuilhof, van Leeuwen, J.L., Turnhout, van, M.C., Turnhout, M.C., van, van Lagen, B., Henk Schipper, van Turnhout, M.C., Schipper, H., Leeuwen, van, J.L., Turnhout, MC Mark van, Lagen, van, B., Schipper, H, Leeuwen, JL Johan van, Lagen, B., van, Zuilhof, Han, Zuilhof, H., Mark C van Turnhout, Sander Kranenbarg, Lagen, B van, Kranenbarg, S, Johan L van Leeuwen   +24 more
core   +1 more source

Gold Nanomaterials and Bone/Cartilage Tissue Engineering: Biomedical Applications and Molecular Mechanisms

Frontiers in Chemistry, 2021
Recently, as our population increasingly ages with more pressure on bone and cartilage diseases, bone/cartilage tissue engineering (TE) have emerged as a potential alternative therapeutic technique accompanied by the rapid development of materials ...
Yifeng Shi, Yifeng Shi, Yifeng Shi, Xuyao Han, Shuang Pan, Yuhao Wu, Yuhan Jiang, Jinghao Lin, Yihuang Chen, Haiming Jin, Haiming Jin   +10 more
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Cartilage homeostasis in health and rheumatic diseases [PDF]

Arthritis Research & Therapy, 2009
As the cellular component of articular cartilage, chondrocytes are responsible for maintaining in a low-turnover state the unique composition and organization of the matrix that was determined during embryonic and postnatal development. In joint diseases, cartilage homeostasis is disrupted by mechanisms that are driven by combinations of biological ...
Goldring, Mary B, Marcu, Kenneth B
openaire   +2 more sources

lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration

Stem Cell Research & Therapy, 2019
With the increasing incidence of cartilage-related diseases such as osteoarthritis (OA) and intervertebral disc degeneration (IDD), heavier financial and social burdens need to be faced.
Jian Zhu, Wei Yu, Yitian Wang, Kaishun Xia, Yuluan Huang, Ankai Xu, Qixin Chen, Bing Liu, Huimin Tao, Fangcai Li, Chengzhen Liang   +10 more
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Histone Modifications and Chondrocyte Fate: Regulation and Therapeutic Implications

Frontiers in Cell and Developmental Biology, 2021
The involvement of histone modifications in cartilage development, pathology and regeneration is becoming increasingly evident. Understanding the molecular mechanisms and consequences of histone modification enzymes in cartilage development, homeostasis ...
Chao Wan, Chao Wan, Chao Wan, Fengjie Zhang, Fengjie Zhang, Fengjie Zhang, Hanyu Yao, Hanyu Yao, Hanyu Yao, Haitao Li, Rocky S. Tuan, Rocky S. Tuan, Rocky S. Tuan   +12 more
doaj   +1 more source