Results 1 to 10 of about 96,982 (307)

Bioinspired scaffold recapitulating chondrogenic ontogeny and microenvironment for functional cartilage regeneration [PDF]

Bioactive Materials
Focal articular cartilage defects often progress to osteoarthritis, imposing a substantial global health burden. Current neglect of cartilage developmental regulation and cartilage microenvironment compromises therapeutic efficacy.
Tianyu Yu, Xun Sun, Yang Liu, Yiming Dou, Ye Tian, Yiming Zhang, Genghao Wang, Lianyong Wang, Jianmin Han, Xiaohong Li, Xigao Cheng, Honglong Li, Haobo Pan, Lei Yang, Yanhong Zhao, Qiang Yang   +15 more
doaj   +2 more sources

Insights of cartilage imaging in cartilage regeneration. [PDF]

World J Orthop
Cartilage, as a specialized connective tissue, underpins joint mobility and mechanical load distribution while exhibiting inherently limited self-repair capabilities. This comprehensive review redefines the current landscape of cartilage imaging by exploring conventional and advanced modalities used to assess both the structural and biochemical ...
Jeyaraman M, Jeyaraman N, Nallakumarasamy A, Ramasubramanian S, Muthu S.   +4 more
europepmc   +2 more sources

Cartilage Regeneration [PDF]

Journal of the American Academy of Orthopaedic Surgeons, 2013
Cartilage damaged by trauma has a limited capacity to regenerate. Current methods of managing small chondral defects include palliative treatment with arthroscopic débridement and lavage, reparative treatment with marrow-stimulation techniques (eg, microfracture), and restorative treatment, including osteochondral grafting and autologous chondrocyte ...
Rocky S, Tuan, Antonia F, Chen, Brian A, Klatt   +2 more
openaire   +4 more sources

Blocking calcium-MYC regulatory axis inhibits early dedifferentiation of chondrocytes and contributes to cartilage regeneration [PDF]

Stem Cell Research & Therapy
Tissue engineering technology for cartilage regeneration has increasingly emerged as a preferred method for repairing cartilage defects. However, the loss of chondrocyte-specific phenotypes during in vitro expansion, commonly referred to as ...
Xu Wu, Yaoyao Fu, Jing Ma, Honglei Wang, Chenlong Li, Yaying Zhu, Qixuan Wang, Xudong Guo, Tianyu Zhang, Aijuan He   +9 more
doaj   +2 more sources

Differential regulation of the water channel protein aquaporins in chondrocytes of human knee articular cartilage by aging

Scientific Reports, 2021
Knee cartilage is in an aqueous environment filled with synovial fluid consisting of water, various nutrients, and ions to maintain chondrocyte homeostasis.
Bong Soo Kyung, Koo Whang Jung, Woo Jin Yeo, Hye Kyung Seo, Yong-Soo Lee, Dong Won Suh   +5 more
doaj   +1 more source

Effect of CD44 signal axis in the gain of mesenchymal stem cell surface antigens from synovial fibroblasts in vitro

Heliyon, 2022
Tissue-residing mesenchymal stromal/stem cells (MSCs) have multipotent characteristics that are important for adult tissue homeostasis and tissue regeneration after injury.
Masaaki Isono, Jun Takeuchi, Ami Maehara, Yusuke Nakagawa, Hiroki Katagiri, Kazumasa Miyatake, Ichiro Sekiya, Hideyuki Koga, Yoshinori Asou, Kunikazu Tsuji   +9 more
doaj   +1 more source

Biomimetic sulphated alginate hydrogels suppress IL-1β-induced inflammatory responses in human chondrocytes [PDF]

European Cells & Materials, 2017
Loss of articular cartilage from ageing, injury or degenerative disease is commonly associated with inflammation, causing pain and accelerating degradation of the cartilage matrix.
Ø Arlov, E Öztürk, M Steinwachs, G Skjåk-Bræk, M Zenobi-Wong   +4 more
doaj   +1 more source

Curcumin loaded polycaprolactone scaffold capable of anti-inflammation to enhance tracheal cartilage regeneration

Materials & Design, 2022
An inflammatory reaction is one of the primary reasons for deteriorating tracheal cartilage regeneration in vivo, hindering tracheal defect restoration with prominent fibrosis and granulation hyperplasia.
Minglei Yang, Weiyan Sun, Long Wang, Hai Tang, Xiang Xu, Liangwei Yang, Junjun Ni, Kuoen Zheng, Xu Jiang, Weiwen Xu, Guofang Zhao, Yunlang She, Lei Zhang, Dong Xie, Chang Chen   +14 more
doaj   +1 more source

Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model [PDF]

, 2012
Introduction: This study aimed to determine whether, as in osteoarthritis, increased levels of interleukin-6 (IL-6) are present in the synovial fluid of patients with symptomatic cartilage defects and whether this IL-6 affects cartilage regeneration as ...
Beekhuizen, M. (Michiel), Bekkers, J.E.J. (Joris ), Bot, A.G.J. (Arjan), Creemers, L.B. (Laura), Dhert, W.J.A. (Wouter), Geurts, T.B.P., Osch, G.J.V.M. (Gerjo) van, Rutgers, M. (Marijn), Saris, D.B.F. (Daniel), Tsuchida, A.I. (Anika)   +9 more
core   +9 more sources

Dynamically adaptive scaffolds for cartilage tissue engineering

MedComm – Biomaterials and Applications, 2023
Although cartilage regeneration is a continuously changing, complex process, most studies on cartilage tissue regeneration have focused on specific stages, thereby promoting regeneration in only a limited period rather than over the entire repair process.
Yachen Peng, Yaling Zhuang, Yanbo Zhang, Jianlin Zuo, Jianxun Ding   +4 more
doaj   +1 more source