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Polysaccharide-based hydrogels for cartilage regeneration. [PDF]
Front Cell Dev BiolChen N +6 more
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Chondroinductive Peptides for Cartilage Regeneration
Tissue Engineering Part B: Reviews, 2022Inducing and maintaining a hyaline cartilage phenotype are the greatest challenge for cartilage regeneration. Synthetic chondroinductive biomaterials might be the answer to the unmet clinical need for a safe, stable, and cost-effective material capable of inducing true hyaline cartilage formation.
Boushra, Ajeeb +2 more
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Immunology and cartilage regeneration
Immunologic Research, 2015The intrinsic regenerative capacity of avascular cartilage is limited. Cartilage injuries result in chronic, non-healing lesions requiring surgical management. Frequently, these surgical techniques make use of allogeneic cells and tissues. This review discusses the immune status of these materials.
Benjamin, Smith +2 more
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Cartilage Regeneration by Gene Therapy
Current Gene Therapy, 2003Damage of articular cartilage is a frequent clinical problem and is commonly considered to be irreversible. Full-thickness defects may lead to the formation of fibrous repair tissue of minor mechanical quality, while partial-thickness lesions hardly show any repair response.
K, Gelse, K, von der Mark, H, Schneider
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Regeneration of Articular Cartilage
2005Loss of articular cartilage from the ends of bones forming diarthrodial joints can be the source of profound pain and disability, and eventually lead to complete degeneration of the joint, necessitating total joint replacement. Until a few years ago, there seemed little hope of treating such defects.
B, Kinner, R M, Capito, M, Spector
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Articular Cartilage: Structure and Regeneration
Tissue Engineering Part B: Reviews, 2010Articular cartilage (AC) has no or very low ability of self-repair, and untreated lesions may lead to the development of osteoarthritis. One method that has been proven to result in long-term repair or isolated lesions is autologous chondrocyte transplantation.
José, Becerra +5 more
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Functional biomaterials for cartilage regeneration
Journal of Biomedical Materials Research Part A, 2012AbstractThe injury and degeneration of articular cartilage and associated arthritis are leading causes of disability worldwide. Cartilage tissue engineering as a treatment modality for cartilage defects has been investigated for over 20 years. Various scaffold materials have been developed for this purpose, but has yet to achieve feasibility and ...
Zigang, Ge +4 more
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Articular Cartilage Regeneration
2016The glassy translucent material found at the ends of bones, within synovial joints, is termed articular cartilage. While healthy, it provides a low-friction bearing surface, preventing bone-to-bone contact, and to an extent, absorb shock during vigorous activities.
Georg N. Duda +3 more
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Articular Cartilage Regeneration Using Periosteum
Clinical Orthopaedics and Related Research, 1999Periosteum has chondrogenic potential that makes it possible to repair or regenerate cartilage in damaged joints. Whole periosteal explants also can be cultured in vitro for the purpose of studying chondrogenesis. This chondrogenic potential arises because the cambium layer of periosteum contains chondrocyte precursor cells that form cartilage during ...
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