Results 61 to 70 of about 96,982 (307)

Ex Vivo Systems to Study Chondrogenic Differentiation and Cartilage Integration

Journal of Functional Morphology and Kinesiology, 2021
Articular cartilage injury and repair is an issue of growing importance. Although common, defects of articular cartilage present a unique clinical challenge due to its poor self-healing capacity, which is largely due to its avascular nature.
Graziana Monaco, Alicia J. El Haj, Mauro Alini, Martin J. Stoddart   +3 more
doaj   +1 more source

Role of PACAP and VIP Signalling in Regulation of Chondrogenesis and Osteogenesis [PDF]

, 2016
Pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are multifunctional proteins that can regulate diverse physiological processes. These are also regarded as neurotrophic and anti-inflammatory substances in
A Akopian, A Hernanz, A Miyata, A Mobasheri, A Pan, A Sanchez, A Suzuki, A Szabo, AI Gogakos, B Botz, B Crombrugghe de, B Lv, B Sandor, B Winding, C Bataille, C Matta, CS Kovacs, CS Somogyi, D Li, D Reglodi, D Reglodi, D Reglodi, D Vaudry, E Banki, E Fabian, E Persson, EL Hohmann, G Chen, GN Onuoha, H Miraoui, H Ogawa, H Oka, H Okura, HH Strange-Vognsen, HJ Kwon, HJ Park, HW Ehlen, HW Lee, I Harfi, J Fodor, J Yang, JA Waschek, JH Jonason, JH Kim, JY Yan, K Csanaky, K Dohi, K Gelse, K Hayashi, K Schuhmann, K Tanaka, KA Pavelock, KB Paiva, L Pulsatelli, L Wang, L Zhao, M Barberi, M Carrion, M Hughes-Fulford, M Koppan, MB Goldring, MC Dvorakova, MD Payet, MJ Serrano, MM Heimesaat, MP Yavropoulou, N Ahmed, N Sangphech, N Sassi, N Shintani, P Gourlet, P Lundberg, P Niewiadomski, Q Lu, R Barrett-Jolley, R Brubel, R Yu, R Zakany, R Zakany, R Zakany, R Zhang, RL Pitts, RT Franceschi, S Giunta, S Hattori, S Onoue, S Piera-Velazquez, S Rahman, SJ Rozzi, T Juhasz, T Juhasz, T Juhasz, T Juhasz, T Juhasz, T Mustafa, TF Li, TW Moody, UH Lerner, V May, V Sethi, W Ma, Y Duan, Y Juarranz, Y Maeda, Y Rais, Y Zhang, YM Yoo, YT Konttinen   +107 more
core   +2 more sources

Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction

Advanced Functional Materials, EarlyView.
Despite over three decades of research, no tissue‐engineered solution for auricular reconstruction in microtia patients has reached clinical translation. The key challenge lies in generating functional elastic cartilage ex vivo. Here, we integrate synergistic cell‐biomaterial strategies to engineer auricular grafts with mechanical and histological ...
Philipp Fisch, Sandra Kessler, Simone Ponta, Anna Puiggalí‐Jou, Guoliang Lyu, Killian Flégeau, Anastasiya Martyts, Florian Roth, David Fercher, Filippo M. Rijli, Daniel Simmen, Eva Novoa Olivares, Thomas Linder, Marcy Zenobi‐Wong   +13 more
wiley   +1 more source

Surgical Treatment of Articular Cartilage Defects in the Knee: Are We Winning?

Advances in Orthopedics, 2012
Articular cartilage (AC) injury is a common disorder. Numerous techniques have been employed to repair or regenerate the cartilage defects with varying degrees of success.
A. R. Memon, J. F. Quinlan
doaj   +1 more source

Medial opening-wedge high tibial osteotomy with microfracture in treatment of varus medial compartmental knee osteoarthritis: clinical outcomes and second-look arthroscopic results

Frontiers in Bioengineering and Biotechnology, 2023
Objective: This study aimed to investigate the clinical outcomes of medial opening high tibial osteotomy (MOWHTO) combined with arthroscopic microfracture in the treatment of varus medial compartmental knee osteoarthritis and to assess cartilage ...
Yunpeng Bai, Binhui Lin, Miao Wang, Haoliang Ding, Weibing Sun, Jian Sun   +5 more
doaj   +1 more source

Development of Bone Targeting Drugs. [PDF]

, 2017
The skeletal system, comprising bones, ligaments, cartilage and their connective tissues, is critical for the structure and support of the body. Diseases that affect the skeletal system can be difficult to treat, mainly because of the avascular cartilage
Alméciga-Díaz, Carlos J., Mackenzie, William G., Mason, Robert W., Orii, Tadao, Sawamoto, Kazuki, Stapleton, Molly, Tomatsu, Shunji   +6 more
core   +2 more sources

In Situ 3D Bioprinting: Impact of Cross‐Linking on the Adhesive Properties of Hydrogels

Advanced Functional Materials, EarlyView.
In situ 3D bioprinting enables the direct deposition of cell‐laden, adhesive biomaterials for on‐site tissue regeneration. This review provides a comprehensive overview of how cross‐linking influences the bioadhesive properties of hydrogels used in 3D bioprinting, highlighting cross‐linking triggers, bioadhesion mechanisms, polymer interpenetration ...
Odile Romero Fernandez, Mulazim Hussain Asim, Shumaila Arshad, Gergely Kali, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Promotion of osteochondral repair through immune microenvironment regulation and activation of endogenous chondrogenesis via the release of apoptotic vesicles from donor MSCs

Bioactive Materials
Utilizing transplanted human umbilical cord mesenchymal stem cells (HUMSCs) for cartilage defects yielded advanced tissue regeneration, but the underlying mechanism remain elucidated.
Guangzhao Tian, Han Yin, Jinxuan Zheng, Rongcheng Yu, Zhengang Ding, Zineng Yan, Yiqi Tang, Jiang Wu, Chao Ning, Xun Yuan, Chenxi Liao, Xiang Sui, Zhe Zhao, Shuyun Liu, Weimin Guo, Quanyi Guo   +15 more
doaj   +1 more source

O-alg-THAM/gel hydrogels functionalized with engineered microspheres based on mesenchymal stem cell secretion recruit endogenous stem cells for cartilage repair

Bioactive Materials, 2023
Lacking self-repair abilities, injuries to articular cartilage can lead to cartilage degeneration and ultimately result in osteoarthritis. Tissue engineering based on functional bioactive scaffolds are emerging as promising approaches for articular ...
Yucong Li, Linlong Li, Ming Wang, Boguang Yang, Baozhen Huang, Shanshan Bai, Xiaoting Zhang, Nan Hou, Haixing Wang, Zhengmeng Yang, Chong Tang, Ye Li, Wayne Yuk-Wai Lee, Lu Feng, Micky D. Tortorella, Gang Li   +15 more
doaj   +1 more source

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source