Results 121 to 130 of about 136,745 (341)

Recent Progress in Cartilage Tissue Engineering—Our Experience and Future Directions

Engineering, 2017
Given the limited spontaneous repair that follows cartilage injury, demand is growing for tissue engineering approaches for cartilage regeneration. There are two major applications for tissue-engineered cartilage.
Yu Liu, Guangdong Zhou, Yilin Cao
doaj   +1 more source

Interfacial Yield Stress Response in Synthetic Mucin Solutions

Advanced Materials Interfaces, EarlyView.
The solution rheology of novel synthetic mucins mimicking natural mucin domains is studied. Like many natural mucin solutions, apparent solid‐like rheology is seen. However, no bulk structural features are found to explain it. Interfacial rheology and robust modelling reveal that this arises from molecular associations at the air–water interface ...
Sumit Sunil Kumar, Travis Leadbetter, J. Brandon McClimon, Manuel A. Lema, Farhana M. Khan, Prashant K. Purohit, Adam B. Braunschweig, Robert W. Carpick   +7 more
wiley   +1 more source

4D Bioprinted Self‐Folding Scaffolds Enhance Cartilage Formation in the Engineering of Trachea

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
A bilayer self‐folding scaffold, triggerable by humidity, is fabricated via 4D bioprinting for trachea engineering. An analytical model is derived to predict its radius of curvature, enabling its scalability. Cartilage progenitor cells seeded on the scaffold perceive scaffold final curvature and react to it, by enhancing the upregulation of pro ...
Irene Chiesa, Alessio Esposito, Giovanni Vozzi, Riccardo Gottardi, Carmelo De Maria   +4 more
wiley   +1 more source

Vertical Membrane‐Free Organ‐on‐a‐Chip for High‐Throughput In Vitro Studies and Drug Screening

Advanced Materials Technologies, EarlyView.
This novel microfluidic organ‐on‐a‐chip (OoC) platform enables cost‐effective, high‐throughput in vitro modeling. With vertical compartmentalization and gravity‐driven flow, it eliminates porous membranes and external pumps. Successfully generating intestine, cartilage, and tendon models, this study demonstrates drug responses, including 5‐fluorouracil
Xavier Barceló, Pooya Azizian, Blanca del Pozo, Marta Olle‐Monge, Lourdes Gombau, Joan M. Cabot   +5 more
wiley   +1 more source

Intraarticular injection of SHP2 inhibitor SHP099 promotes the repair of rabbit full-thickness cartilage defect

Journal of Orthopaedic Translation, 2022
Background: Cartilage repair has been a challenge in the field of orthopaedics for decades, highlighting the significance of investigating potential therapeutic drugs.
Ziying Sun, Xingquan Xu, Zhongyang Lv, Jiawei Li, Tianshu Shi, Heng Sun, Kuoyang Sun, Guihua Tan, Wenqiang Yan, Yannick Xiaofan Yang, Rui Wu, Jia Xu, Hu Guo, Qing Jiang, Dongquan Shi   +14 more
doaj  

Thermoanalytical and histological study of intra-articular papain-induced degradation and repair of rabbit cartilage. II. Mature animals. [PDF]

, 1976
Tamás Farkas, M Bihari-Varga, Tamás Bı́ró   +2 more
openalex   +1 more source

Local stimulation of articular cartilage repair by transplantation of encapsulated chondrocytes overexpressing human fibroblast growth factor 2 (FGF-2) in vivo [PDF]

, 2006
Background Defects of articular cartilage are an unsolved problem in orthopaedics. In the present study, we tested the hypothesis that gene transfer of human fibroblast growth factor 2 (FGF-2) via transplantation of encapsulated genetically modified ...
Arntzen, David, Cucchiarini, Magali, Kaul, Gunter, Kohn, Dieter, Madry, Henning, Menger, Michael D., Trippel, Stephen B., Zurakowski, David   +7 more
core  

Miniaturized Devices for On‐the‐Spot Generation of Small‐Diameter Vascular Grafts

Advanced Materials Technologies, EarlyView.
An intracorporeal extrusion device is developed for on‐the‐spot generation of vascular grafts with tunable diameters spanning from 1 to 6 mm. The device uses biomimetic polymers and light, to promptly obtaining biocompatible and high‐burst pressure‐resistant grafts.
Deyanira Hernandez‐Sanchez, Maxime‐Emmanuel Comtois‐Bona, Antony El‐Khoury, Sergio David Garcia Schejtman, Aidan Macadam, Juan‐David Figueroa‐Alegria, Jesus M. Calderon‐Torres, Irene Guzmán‐Soto, Marc Ruel, Erik J. Suuronen, Marcelo Muñoz, Emilio I. Alarcon   +11 more
wiley   +1 more source

High-precision bioactive scaffold with dECM and extracellular vesicles targeting 4E-BP inhibition for cartilage injury repair

Materials Today Bio
The restoration of cartilage injuries remains a formidable challenge in orthopedics, chiefly attributed to the absence of vascularization and innervation in cartilage. Decellularized extracellular matrix (dECM) derived from cartilage, following antigenic
Yu Han, Yixin Dong, Bo Jia, Xiangyu Shi, Hongbo Zhao, Shushan Li, Haitao Wang, Binbin Sun, Li Yin, Kerong Dai   +9 more
doaj  

A comparison of BMP2 delivery by coacervate and gene therapy for promoting human muscle-derived stem cell-mediated articular cartilage repair

Stem Cell Research & Therapy, 2019
Background Osteoarthritis and cartilage injury treatment is an unmet clinical need. Therefore, development of new approaches to treat these diseases is critically needed.
Xueqin Gao, Haizi Cheng, Hassan Awada, Ying Tang, Sarah Amra, Aiping Lu, Xuying Sun, Guijin Lv, Charles Huard, Bing Wang, Xiaohong Bi, Yadong Wang, Johnny Huard   +12 more
doaj   +1 more source