Results 151 to 160 of about 36,826 (221)
Molecular Interactions of Viral Insulin/IGF‐Like Peptides With Zebrafish Receptors
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Signaling through the insulin receptor (IR) and the type 1 insulin‐like growth factor receptor (IGF1R) is modulated by secreted hormones and growth factor ligands (e.g., insulin and insulin‐like growth factor 1, IGF1). Impaired signaling in these receptors often leads to diabetes and oncogenic diseases.
Lev Levintov, Harish Vashisth
wiley +1 more source
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Allosteric communication is fundamental to the function of proteins, but identifying the residue‐level pathways through which signals travel and their directionality is still a major challenge. Here we present a multi‐metric information‐theoretic framework that identifies candidate allosteric communication pathways from a single protein ...
Aysima Hacisuleyman, Dirk Fasshauer
wiley +1 more source
Responsive Materials, EarlyView.Nanoheterojunctions have been synthesized as responsive biomaterials for cascade targeting of tumor cells and mitochondria, ROS‐mediated apoptosis and Cu‐promoted cuproptosis. And drug‐device‐field integration as an advanced paradigm of tumor treatment was employed for photo‐triggered tumor cell elimination in vitro and lesion eradication in vivo ...
Zhe Liu +3 more
wiley +1 more source
Small, EarlyView.Single‐molecule localization microscopy is exploited to quantify the number of hemoglobin copies bound to specific receptors on S. aureus wall. This quantification supports the design of a photoactive derivative of hemoglobin able to photo‐inactivate S.
Pietro Delcanale +10 more
wiley +1 more source
Small, EarlyView.We have designed a new type of nanoparticle‐based optical biosensor whose surface has been engineered with peptide‐polymer hybrids so that sensing of small protein‐protein interactions can be performed in simple buffers and complex biological liquids including animal and human serum. Measurements can be performed simply by mixing nanosensors with media
Gurunath Apte +10 more
wiley +1 more source
Small, EarlyView.Tunable nano‐twisted structures of novel isomeric macrocycles, which were controlled by cis/trans isomerizations of stiff‐stilbene units under light irradiations, have been exploited to modulate bent and planar configurations of 9,14‐diphenyl‐9,14‐dihydrodibenzo[a,c]phenazine (DPAC) moieties and adjust their ratiometric emissions. External factors, i.e.
Nguyen Thanh Trung +11 more
wiley +1 more source
Ethynyl Substituents as Rheostatic Triggers in Single‐Molecule Junctions
Small, EarlyView.We demonstrate a method to impart rheostatic behavior by extending the core π‐system with ethynyl substituents. Compressing and relaxing single molecule junctions gave continuous changes in conductance, akin to a traditional variable resistor: a rheostat.
R. Tom Abram +8 more
wiley +1 more source
A Cytoplasmic pH Sensor Redefines Gating in Bacterial Urea Channels and Acid Resistance
Small, EarlyView.Bacterial survival in acidic environments requires pH‐gated urea channels. Utilizing complementary approaches, we identify a conserved cytoplasmic glutamic acid residue as a pH sensor in UreI channels. Whereas Gram‐positive bacteria rely solely on this sensor, Gram‐negative bacteria employ a dual‐sensor mechanism with periplasmic residues, revealing a ...
Anna Stoib +10 more
wiley +1 more source
TESOL Quarterly, EarlyView.Abstract Generative artificial intelligence (GenAI) in digital multimodal composing (DMC) presents both opportunities and challenges for second language (L2) research and pedagogy. While GenAI tools provide linguistic and multimodal support, they also raise concerns about biased information, culturally generic outputs, and technological overreliance ...
Jialei Jiang
wiley +1 more source