Journal of Nanobiotechnology, 2021 Background Carvedilol, the anti-hypertensive drug, has poor bioavailability when administered orally. Ethosomes-mediated transdermal delivery is considered a potential route of administration to increase the bioavailability of carvedilol.
Padmanabha Rao Amarachinta +5 more
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Long‐Term Mortality Associated With Use of Carvedilol Versus Metoprolol in Heart Failure Patients With and Without Type 2 Diabetes: A Danish Nationwide Cohort Study [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Carvedilol may have favorable glycemic properties compared with metoprolol, but it is unknown if carvedilol has mortality benefit over metoprolol in patients with type 2 diabetes (T2D) and heart failure with reduced ejection fraction (HFrEF ...
Brian Schwartz +8 more
doaj +3 more sources
Drug delivery of carvedilol (cardiovascular drug) using phosphorene as a drug carrier: a DFT study
Journal of Taibah University for Science, 2022 2D nanomaterial phosphorene is a chemistically stable, biocompatible, and biodegradable drug delivery platform. This study investigates the drug loading efficiency of phosphorene for the cardiovascular drug carvedilol using density-functional theory (DFT)
Javeria Rafique +8 more
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The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure [PDF]
New England Journal of Medicine, 1996 BACKGROUND Controlled clinical trials have shown that beta-blockers can produce hemodynamic and symptomatic improvement in chronic heart failure, but the effect of these drugs on survival has not been determined.
Milton Packer +6 more
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Chitosan as Valuable Excipient for Oral and Topical Carvedilol Delivery Systems
Pharmaceuticals, 2021 Chitosan is a valued excipient due to its biocompatibility properties and increasing solubility of poorly water-soluble drugs. The research presented in this paper concerns the preparation of binary combinations of chitosan (deacetylated chitin) with ...
Szymon Sip +6 more
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Clinical Pharmacology of Carvedilol [PDF]
Journal of Cardiovascular Pharmacology and Therapeutics, 1999 Background: There is now a wealth of data supporting the use of beta-blockers in heart failure and the additional pharmacological properties of carvedilol are thought to play an important role in the therapeutic efficacy of carvedilol in this disease.
William D. Carlson, Kristin C. Oberg
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Frontiers in Pharmacology, 2021 Garlic oil and its primary component, diallyl disulphide (DADS), were tested in rats with isoprenaline (ISO) induced myocardial infarction for cardioprotective benefits when combined with carvedilol.
Syed Mohammed Basheeruddin Asdaq +8 more
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Post-carvedilol myocardial function in cats with obstructive hypertrophic cardiomyopathy [PDF]
Frontiers in Veterinary ScienceIntroductionHypertrophic cardiomyopathy (HCM) is the most prevalent cardiac disease in cats, and one phenotype includes obstructive HCM with dynamic left ventricular outflow tract obstruction (DLVOTO). Myocardial function has been reported to be lower in
Takahiro Saito +9 more
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Carvedilol Confers Ferroptosis Resistance in HL-1 Cells by Upregulating GPX4, FTH1, and FTL1 and Inducing Metabolic Remodeling Under Hypoxia/Reoxygenation [PDF]
AntioxidantsHypoxia/reoxygenation (HR) often occurs under cardiac pathological conditions, and HR-induced oxidative stress usually leads to cardiomyocyte damage. Carvedilol, a non-selective β-blocker, is used clinically to treat cardiac ischemia diseases.
Yi-Chin Li, Mei-Ling Cheng
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Oral delivery of the non-β-blocking R-carvedilol enantiomer for skin cancer chemoprevention in SKH-1 mice [PDF]
AAPS OpenPurpose Skin cancer remains the most prevalent cancer worldwide with its incidence continuously rising. Previous studies have demonstrated the efficacy of the β-blocker carvedilol and its non-β-blocking enantiomer R-carvedilol in mitigating UV-induced ...
Pabitra K. Sardar +7 more
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