Results 71 to 80 of about 38,527 (248)

Smad3 inactivation and MiR-29b upregulation mediate the effect of carvedilol on attenuating the acute myocardium infarction-induced myocardial fibrosis in rat. [PDF]

PLoS ONE, 2013
Carvedilol, a nonselective β-adrenoreceptor antagonist, protects against myocardial injury induced by acute myocardium infarction (AMI). The mechanisms underlying the anti-fibrotic effects of carvedilol are unknown.
Jie-Ning Zhu, Ren Chen, Yong-Heng Fu, Qiu-Xiong Lin, Shuai Huang, Lin-Lin Guo, Meng-Zhen Zhang, Chun-Yu Deng, Xiao Zou, Shi-Long Zhong, Min Yang, Jian Zhuang, Xi-Yong Yu, Zhi-Xin Shan   +13 more
doaj   +1 more source

Efficacy of sacubitril/valsartan vs. enalapril at lower than target doses in heart failure with reduced ejection fraction: the PARADIGM-HF trial. [PDF]

, 2016
AimsIn this analysis, we utilized data from PARADIGM-HF to test the hypothesis that participants who exhibited any dose reduction during the trial would have similar benefits from lower doses of sacubitril/valsartan relative to lower doses of enalapril ...
Claggett, Brian, Desai, Akshay S, Lefkowitz, Martin, McMurray, John JV, Packer, Milton, Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) Investigators, Rouleau, Jean, Shi, Victor, Solomon, Scott D, Swedberg, Karl, Teerlink, John R, Vardeny, Orly, Zile, Michael R   +12 more
core   +1 more source

Effects of different degrees of sympathetic antagonism on cytokine network in patients with ischemic dilated cardiomyopathy [PDF]

, 2005
BACKGROUND: The proinflammatory cytokines have been implicated in the pathogenesis of heart failure. Recent studies have shown that beta-adrenergic blockade can modulate cytokine production.
Cinquegrana, G., D'Aniello, L., De Prisco, Grande, G., Landi, M., M., PETRETTA, MARIO, SPINELLI, LETIZIA   +7 more
core   +1 more source

Sleep characteristics and self‐reported sleep quality in the oldest‐old: Results from a prospective longitudinal cohort study

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Little is known about the correlation between subjective perception and objective measures of sleep quality in particular in the oldest‐old. The aim of this study was to perform longitudinal home sleep monitoring in this age group, and to correlate results with self‐reported sleep quality.
Hugo Saner, Kevin Möri, Narayan Schütz, Philipp Buluschek, Tobias Nef   +4 more
wiley   +1 more source

Oral delivery of the non-β-blocking R-carvedilol enantiomer for skin cancer chemoprevention in SKH-1 mice

AAPS Open
Purpose Skin cancer remains the most prevalent cancer worldwide with its incidence continuously rising. Previous studies have demonstrated the efficacy of the β-blocker carvedilol and its non-β-blocking enantiomer R-carvedilol in mitigating UV-induced ...
Pabitra K. Sardar, Steven Yeung, Ruby Tow, Jacqueline Luga, Matthew Huang, Ayaz Shahid, Bradley T. Andresen, Ying Huang   +7 more
doaj   +1 more source

Clinic of dogs with dilated cardiomyopathy (DCM) treated or not by carvedilol [PDF]

, 2011
O tratamento convencionalmente preconizado para cães acometidos pela CMD consiste na prescrição de vasodilatadores, agentes inotrópicos positivos (digitálico), diuréticos, dieta hipossódica e, quando necessário, antiarrítmicos.
BALIEIRO, Júlio César Carvalho, LARSSON, Maria Helena Matiko Akao, LEOMIL NETO, Moacir, OLIVEIRA, Valéria Marinho de, PEREIRA, Elaine Cristina Soares, PEREIRA, Guilherme Gonçalves   +5 more
core   +1 more source

Management Strategies for Refractory Esophageal Varices

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Refractory esophageal varices that are difficult to control or unresponsive to endoscopic treatment remain a major clinical challenge in the management of portal hypertension. This review provides a comprehensive overview of treatment strategies for these cases, along with a comparative analysis of the American Association for the Study of ...
Keita Maki, Hiroaki Haga, Yoshiyuki Ueno
wiley   +1 more source

EVALUATION OF CARVEDILOL EFFECTS ON THE BASIC DATA OF LEFT VENTRICLE SYSTOLIC AND DIASTOLIC FUNCTION AFTER ACUTE MYOCARDIAL INFARCTION

Российский кардиологический журнал, 2001
We have examinated 106 patients with primary acute myocardial Q-infarction. Favourable effects of carvedilol on basic parameters of central, intracardial and peripheral hemodynamic was identificated.
L. N. Mingazetdinova, L. F. Maxiutova, L. A. Valeeva, A. F. Maxiutova, M. E. Kanshina, V. N. Golubkova   +5 more
doaj  

ESTIMATION OF CLINICAL AND PHARMACOKINETIC EQUIVALENCE OF ORIGINAL AND GENERIC CARVEDILOLS IN PATIENTS WITH HYPERTENSION OF 1-2 GRADES

Рациональная фармакотерапия в кардиологии, 2016
Aim. To study clinical equivalence of original (DilatrendR, ≪Hoffmann-La Roche≫, Switzerland) and of generic (VedicardolR, ≪Synthesis≫, Russia) carvedilols with estimation of their serum level.
E. I. Bambysheva, S. N. Tolpygina, D. F. Guranda, I. E. Koltunov, V. G. Belolipetskaja, S. J. Martsevich   +5 more
doaj   +1 more source

Clinicopathological Characteristics With the Status of Mismatch Repair Deficient Invasive Colorectal Cancer With Spontaneous Regression

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Spontaneous regression of endoscopically invasive colorectal cancer (CRC) after biopsy has been rarely reported. We report three cases of endoscopically invasive CRC with spontaneous regression after biopsy and a review of the literature regarding spontaneous regression of CRC with somatic mismatch repair deficiency (MMR‐d).
Fumiya Okano, Naohisa Yoshida, Yukiko Morinaga, Naoto Iwai, Reo Kobayashi, Ken Inoue, Osamu Dohi, Takashi Ando, Yoshito Itoh   +8 more
wiley   +1 more source