Results 231 to 240 of about 251,083 (336)

Cut Site Selection by the Two Nuclease Domains of the Cas9 RNA-guided Endonuclease [PDF]

, 2014
Hongfan Chen, Ji-Hoon Choi, Scott Bailey
openalex   +1 more source

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

Advanced Science, EarlyView.
Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim, Minhae Cha, Hien Thi My Ong, Jung Yoo, Yu Hyun Jeon, Sang Wu Lee, Soo Yeon Oh, Min‐Jung Kang, Youngsoo Kim, So Hee Kwon   +9 more
wiley   +1 more source

HPV-driven cancers: a looming threat and the potential of CRISPR/Cas9 for targeted therapy. [PDF]

Virol J
Kermanshahi AZ, Ebrahimi F, Taherpoor A, Eslami N, Baghi HB.   +4 more
europepmc   +1 more source

Generation of Genomic Deletions in Mammalian Cell Lines via CRISPR/Cas9

, 2014
Daniel E. Bauer, Matthew C. Canver, Stuart H. Orkin   +2 more
openalex   +2 more sources

The SlDOF9‐SlSWEET17 Module: a Switch for Controlling Sugar Distribution Between Nematode Induced Galls and Roots in Tomato

Advanced Science, EarlyView.
Root‐knot nematode (RKN) disease seriously affects the yield and quality of vegetable crops. SlDOF9‐SlSWEET17 model helps plants resist RKN infection during early stage by switching off the sugar transport capacity of other SlSWEET proteins that are hijacked by RKNs.
Xiaoyun Wang, Zhimei Wang, Xinyue Tang, Jiamei Qin, Xiaoxuan Zhou, Lixia Gu, Huihui Bian, Lulu Sun, Huang Huang, Rui Yang, Jianli Wang, Shaohui Wang, Shuangchen Chen, Zhongren Yang, Wenchao Zhao   +14 more
wiley   +1 more source

Mannosylated neutrophil vesicles targeting macrophages alleviate liver inflammation by delivering CRISPR/Cas9 RNPs. [PDF]

Theranostics
Wu D, Shu H, Zhang M, Wei X, Ji J, Shen H, Zhang H, Xie L, Zhou L, Yang L, Jiang J, Chen C, Tian S, Zhang X, Long X, He X, Wang H.   +16 more
europepmc   +1 more source

The TET3/GATA6 Axis Drives Lipid Metabolism and Therapeutic Vulnerabilities in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
The DNA demethylase TET3 drives lipid metabolic reprogramming in pancreatic ductal adenocarcinoma via a non‐catalytic mechanism. TET3 recruits histone deacetylases to repress GATA6, sustaining lipogenic enzyme expression and ferroptosis resistance.
Shuai Liu, Shaobo Kang, Na Lin, Wenqi Zhang, Shiwen Wang, Yuqing Ren, Xiaofan Ding, Jianxiu Yu, Ruiyu Xie   +8 more
wiley   +1 more source

Learning to utilize internal protein 3D nanoenvironment descriptors in predicting CRISPR-Cas9 off-target activity. [PDF]

NAR Genom Bioinform
Mak JK, Bendandi A, Salim JA, Mazoni I, de Moraes FR, Borro L, Störtz F, Rocchia W, Neshich G, Minary P.   +9 more
europepmc   +1 more source

Colorectal Cancer Cells–Derived Exosomal PIK3CA Mutation DNA Promotes Tumor Metastasis by Activating Fibroblast and Affecting Tumor Metastatic Microenvironment

Advanced Science, EarlyView.
PIK3CAH1047R DNA in colorectal cancer (CRC) cell‐derived exosomes can be delivered into recipient fibroblasts, where it is transcribed and translated, leading to the activation of fibroblasts into cancer‐associated fibroblasts, which secrete elevated levels of IL6. The simultaneous detection and targeting of PIK3CAH1047R mutation and IL6 may serve as a
Rui Wang, Wanming Li, Yuqiong Lv, Wei Ba, Ying Jiang, Xiaoshuai Li, Jin Fang   +6 more
wiley   +1 more source

Engineering tripartite gene editing machinery for highly efficient non-viral targeted genome integration. [PDF]

Nat Commun
Nam H, Xie K, Majumdar I, Wang J, Yang S, Starzyk J, Lee D, Shan R, Li J, Wu H.   +9 more
europepmc   +1 more source