Results 231 to 240 of about 278,076 (329)

Targeted Delivery of CRISPR/Cas9‐Mediated Cancer Gene Therapy via Liposome‐Templated Hydrogel Nanoparticles

, 2017
Zeming Chen, Fuyao Liu, Yanke Chen, Jun Liu, Xiaoying Wang, Ann T. Chen, Gang Deng, Hongyi Zhang, Jie Liu, Zhangyong Hong, Jiangbing Zhou   +10 more
openalex   +2 more sources

Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation

Advanced Science, EarlyView.
Deletion of ASAH2 in intestinal epithelial cells induces the accumulation of ganglioside GD3 via regulating ST8SIA1. GD3 is identified as the glycolipid ligand for the inhibitory receptor Siglec‐E on macrophages. GD3/Siglec‐E ligation polarizes macrophages and promotes the proliferation of colonic ST2+ T regulatory cells via the induction of IL‐33. The
Zhishan Xu, Chao Lei, Mukesh K Sriwastva, Ting Wang, Amanguli Tuohongerbieke, Xiaotong Song, Collin Noud, Shannon Derkson, Yi Tan, Gerald Dryden, Craig J McClain, Zhongbin Deng   +11 more
wiley   +1 more source

Combination of Cas9 and adeno-associated vectors enables efficient in vivo knockdown of precise miRNAs in the rodent and primate brain. [PDF]

Proc Natl Acad Sci U S A
Roura-Martinez D, Popa N, Jaouen F, Rombaut C, Lepolard C, Bachar D, Borges A, Cazorla M, Villet M, Moreno S, Marie H, Gascon E.   +11 more
europepmc   +1 more source

Genome editing of WSSV CRISPR/Cas9 and immune activation extends the survival of infected Penaeus vannamei [PDF]

Arnon Pudgerd, Sukanya Saedan, Wanida Santimanawong, Wattana Weerachatyanukul, Pitchanee Jariyapong, Thawatchai Chaijarasphong, Kamonwan Jongsomchai, Kallaya Sritunyalucksana, Rapeepun Vanichviriyakit, Charoonroj Chotwiwatthanakun   +9 more
openalex   +1 more source

Real-time observation of Cas9 postcatalytic domain motions

, 2020
Yanbo Wang, John Mallon, Haobo Wang, Digvijay Singh, Myung Hyun Jo, Boyang Hua, Scott Bailey, Taekjip Ha   +7 more
openalex   +2 more sources

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Callus and endosperm green fluorescence reporter-assisted selection system in maize CRISPR/Cas9 gene editing. [PDF]

BMC Plant Biol
Ge L, Li W, Dou Y, Ma Y, Sun M, Chen X, Feng X, Li Y, Yu Q.   +8 more
europepmc   +1 more source

CRISPR/Cas9-mediated target validation of the splicing inhibitor Pladienolide B

, 2016
Mustapha Aouida, Ayman Eid, Magdy M. Mahfouz   +2 more
openalex   +1 more source

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source

Engineered AcrIIA5 for optogenetic control of CRISPR-Cas9-based genome editing. [PDF]

mLife
Chen Q, Yao J, Lu Y, Qiu R, Deng Z, Sun Y.   +5 more
europepmc   +1 more source