Results 241 to 250 of about 278,076 (329)

CRISPR/Cas9 Targeted Disruption of Herpes Simplex Virus type 1 in a Rabbit Latency Model Reduces Viral Reactivation and Associated Corneal Pathology

, 2018
Christopher M. Owens, Benjamin A. Diner, Robert Fusco, Emily King, Ari E. Friedland, Pankhuri Singhal, Kiran Gogi, Fred Harbinski, Shen Shen, Michael Stefanidakis, Luis Barrera, David Bumcrot, Donna M. Neumann, Charlie Albright   +13 more
openalex   +1 more source

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

Therapeutic applications of CRISPR-Cas9 gene editing. [PDF]

Front Genome Ed
Bharti A, Mudge J.
europepmc   +1 more source

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

Advancing cellulose degradation through synthetic biology: engineered pathways and microbial systems for sustainable biomass conversion. [PDF]

J Anim Sci Biotechnol
Liu X, Quan J, Li Y, Wang X, Zhao J.
europepmc   +1 more source

Functional analysis of autophagy-related genes using CRISPR-Cas9 during metamorphosis of Xenopus tropicalis

, 2018
美津紀 重田
openalex   +1 more source

CRISPR-Cas9-induced double-strand breaks disrupt maintenance of epigenetic information

Mengge Wang, Yingzi Zhang, Chongwei Bi, Mo Li   +3 more
openalex   +1 more source

Surface‐Associated Proteins on Extracellular Vesicles Remodel the Tumor Microenvironment by Potentiating TGF‐β Signaling in a Contact‐Dependent Manner

Advanced Science, EarlyView.
Extracellular vesicles (EVs) released from TGF‐β‐activated CAFs are enriched with ECM proteins such as TSG6 and THBS1, which facilitate their binding to recipient cell membranes. This EV–cell interaction promotes the clustering of CD44 and TGF‐β receptors on the target cell surface, thereby potentiating TGF‐β signaling activity. This study highlights a
Chao Li, Agustin Enciso‐Martinez, Lizhe Zhu, Sarah A. Rotman, Peter A. van Veelen, Roman I. Koning, Hailiang Mei, Peter ten Dijke   +7 more
wiley   +1 more source

Synthetic essentiality of isoprenylcysteine carboxylmethyltransferase in PTEN deficient triple negative breast cancer. [PDF]

Exp Hematol Oncol
Park BS, Kim J, Seo DC, Choi GE, Seo JJ, Lee SE, Kim T.   +6 more
europepmc   +1 more source