Results 261 to 270 of about 200,296 (309)

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

Sex distorter male drive for resistance-resilient population control of the human malaria vector Anopheles gambiae. [PDF]

Nat Commun
Grilli S, Vertsimakha O, Marston L, Gonzalez IA, Burt A, Crisanti A, Bernardini F.   +6 more
europepmc   +1 more source

Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells. [PDF]

Proc Natl Acad Sci U S A
Sabol AL, Mengiste AA, Singh P, Sreekanth V, Hendel SJ, Tran MTN, Barybin AM, Chaudhary S, Harris RM, Liivak KE, Severance ZC, Locicero CM, Kailass K, Lee C, Xu LQ, Butty VL, Choudhary A, Shoulders MD.   +17 more
europepmc   +1 more source

Advances in gene editing for legume improvement: technologies, progress, and prospects. [PDF]

Front Genome Ed
Thakur S, Pareek S, Dixit GP, Meru G, Das A.   +4 more
europepmc   +1 more source

CRISPR-Cas9 off-target effects in urothelial gene therapy: the overlooked risk of P53 mutational signatures in bladder tissue. [PDF]

Ann Med Surg (Lond)
Zahra ST, Ahmed A, Batool V, Hasan AH.
europepmc   +1 more source

Rapid and Efficient Creation of Sweet-Waxy Maize Germplasm via CRISPR/Cas9-Mediated Gene Editing of <i>Sh2</i> and <i>Wx</i>. [PDF]

Curr Issues Mol Biol
Yan X, Li J, Liu H, Jia W, Gao G, Qin Y, Guan L, Duan X, Xu J, Zhou P, Guo Y, Li X, Yang L, Chen H, Li W, Yan P, Zhou Q, Fu Z, Tang J, Wang H.   +19 more
europepmc   +1 more source

Novel African American Colorectal Cancer <i>MSH3</i> Variants Associate With Major Genomic Instability. [PDF]

Hum Mutat
Rashid M, Brim H, Teng S, Sobitan A, Cruz-Cosme R, Qiyi T, Koi M, Casazza K, Surtees JA, Carethers JM, Ashktorab H.   +10 more
europepmc   +1 more source

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CRISPR/Cas9

2023
CRISPR/Cas9 is the genome-editing technology that is most widely used around the world. Its widespread adoption is largely due to its simplicity and ease of use. Here, we introduce the construction of vectors and genome editing of the target gene in cells using the CRISPR/Cas9 system.
Izuho, Hatada, Sumiyo, Morita, Takuro, Horii   +2 more
openaire   +3 more sources

CRISPR/Cas9

2017
CRISPR/Cas9 is a novel method that has become the most widely used genome editing technology around the world. Its widespread adoption is largely due to its simplicity and easy of use. Here, we introduce the construction of vectors and genome editing of the target gene in cells expressing the CRISPR/Cas9 system.
Izuho, Hatada, Takuro, Horii
openaire   +3 more sources