Results 301 to 310 of about 251,083 (336)

Efficacy of CRISPR-Cas9 gene editing for targeting KRAS mutations in pancreatic cancer: a systematic review. [PDF]

Discov Oncol
Hashim HT, Alhatemi AQM, Fatima T, Haque T, Sulaiman FA, Ganim M, Abdullah MA, Kadhum RA, Al-Obaidi AD, Al-Obaidi A.   +9 more
europepmc   +1 more source

Animal models of lung cancer: Phenotypic comparison of different animal models of lung cancer and their application in the study of mechanisms

Animal Models and Experimental Medicine, EarlyView.
Grafts used to construct lung cancer animal models come from various sources, primarily cell lines, patient‐derived tumor tissues, and circulating tumor cells. Based on the sources of grafts and research objectives, lung cancer animal models can be categorized into several types: chemical‐induced models, orthotopic transplantation models, heterotopic ...
Zixuan Yang, Xianbin Zhao, Lili Tan, Pingxinyi Que, Tong Zhao, Wei Huang, Dejiao Yao, Songqi Tang   +7 more
wiley   +1 more source

Construction of a synthetic biology toolkit for the genetic manipulation in the cellulose-producing strain <i>Kosakonia</i> <i>oryzendophytica</i>. [PDF]

Synth Syst Biotechnol
Miao L, Feng W, Ren J, Sun K, Li G, Jiang H.   +5 more
europepmc   +1 more source

Research advancements and evaluation of multifactor‐induced murine models for gastric cancer

Animal Models and Experimental Medicine, EarlyView.
Murine models for gastric cancer. Abstract As one of the most prevalent gastrointestinal malignancies in humans, gastric cancer (GC) is often detected at an advanced stage, resulting in a poor prognosis and ranking it the fifth leading cause of cancer‐related deaths.
Yiqing Wang, Liang Zhang, Weixu Feng, Wanfeng Liu, Xiangyang Xue, Shiyu Feng   +5 more
wiley   +1 more source

High-Throughput Screening to Identify Novel Compounds Affecting the Genome Editing Efficiency of CRISPR System. [PDF]

Molecules
Chang J, Yang X, Zhang T, Sun H, Cheng H, Jia Z, Li Y, Ma S, Sun T, Cao J.   +9 more
europepmc   +1 more source

Multiple low dose streptozotocin‐induced diabetes as a model for studying autoimmune diabetes in humans

Animal Models and Experimental Medicine, EarlyView.
Multiple low dose streptozotocin‐induced diabetes is a valuable animal model of diabetes type 1. It should be improved by further research on autoantigens, microbiota and mucosal immune cells from the gut, but also from other organs. Abstract The autoimmune response directed against pancreatic β cells is the most essential pathogenic process in type 1 ...
Ivan Koprivica, Suzana Stanisavljević, Dragica Mićanović, Ivana Stojanović, Đorđe Miljković   +4 more
wiley   +1 more source

Robust prediction of synthetic gRNA activity and cryptic DNA repair by disentangling cellular CRISPR cleavage outcomes. [PDF]

Nat Commun
Riesenberg S, Kanis P, Karlic R, Maricic T.   +3 more
europepmc   +1 more source

The genetic interaction map of the human solute carrier superfamily. [PDF]

Mol Syst Biol
Wolf G, Leippe P, Onstein S, Goldmann U, Frommelt F, Teoh ST, Girardi E, Wiedmer T, Superti-Furga G.   +8 more
europepmc   +1 more source

Newborn Intravenous Injection of Liposomal CRISPR/Cas9 Complex Has No Incidence of Off-Targets or Tumors in Mice. [PDF]

Pharmaceutics
Monteagudo V, Flores LCB, Lopes M, Fachel FNS, Martins G, Siebert M, Carniel WDS, Garcez TNA, Teixeira HF, Matte U, Giugliani R, Baldo G, Poletto É, Schuh RS.   +13 more
europepmc   +1 more source