Results 51 to 60 of about 1,452,828 (281)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Condensate in quasi two-dimensional turbulence [PDF]
, 2019 We investigate the process of formation of large-scale structures in a turbulent flow confined in a thin layer. By means of direct numerical simulations of the Navier-Stokes equations, forced at an intermediate scale, we obtain a split of the energy ...
Boffetta, Guido, Musacchio, Stefano
core +2 more sources
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Do children receiving care and support have higher rates of school exclusion than their peers?
International Journal of Population Data ScienceThe Children, Young People and Education Committee recently held an inquiry to scrutinise the Welsh Government’s progress in delivering its Programme for Government Commitment to ‘explore radical reform of current services for children looked after and ...
Helen Hodges
doaj +1 more source
Cascade and anti-Cascade Polarization Measurements at 800 GeV/c
, 2006 The polarization of neutral Cascade and anti-Cascade hyperons produced by 800 GeV/c protons on a BeO target at a fixed targeting angle of 4.8 mrad is measured by the KTeV experiment at Fermilab.
A. Alavi-Harati +62 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Improved triplet loss for domain adaptation
IET Computer VisionA technique known as domain adaptation is utilised to address classification challenges in an unlabelled target domain by leveraging labelled source domains.
Xiaoshun Wang +2 more
doaj +1 more source
Electromagnetically induced transparency in multi-level cascade scheme of cold rubidium atoms
, 2004 We report an experimental investigation of electromagnetically induced transparency in a multi-level cascade system of cold atoms. The absorption spectral profiles of the probe light in the multi-level cascade system were observed in cold Rb-85 atoms ...
Ahufinger +42 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source