Results 81 to 90 of about 2,031,294 (377)
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Predictive Testing for Tumor Predisposition Syndromes in Pediatric Relatives: An Asian Experience
Frontiers in Pediatrics, 2020 Approximately 10% of pediatric cancer patients possess germline pathogenic/likely pathogenic variants (PV/LPV) in known tumor predisposition genes.
Jianbang Chiang +7 more
doaj +1 more source
Cascade utilization of lignocellulosic biomass to high-value products
Green Chemistry, 2019 Sustainable and effective methods for biomass pretreatment and biomass cascade utilization are reviewed in this work.
Yanrong Liu +10 more
semanticscholar +1 more source
Not All Pixels Are Equal: Difficulty-Aware Semantic Segmentation via Deep Layer Cascade [PDF]
Computer Vision and Pattern Recognition, 2017 We propose a novel deep layer cascade (LC) method to improve the accuracy and speed of semantic segmentation. Unlike the conventional model cascade (MC) that is composed of multiple independent models, LC treats a single deep model as a cascade of ...
Xiaoxiao Li +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
Factors influencing young people’s transitions from child to adult mental health services in Wales
International Journal of Population Data ScienceObjectives This presentation provides an overview of young peoples’ transitions from child to adult mental health services in Wales. Transitions are unstable times where need for support can be greatest, yet many young adults fail to qualify for ongoing
Louisa Roberts +3 more
doaj +1 more source
Real-Time Observation of Target Search by the CRISPR Surveillance Complex Cascade
Cell Reports, 2017 CRISPR-Cas systems defend bacteria and archaea against infection by bacteriophage and other threats. The central component of these systems are surveillance complexes that use guide RNAs to bind specific regions of foreign nucleic acids, marking them for
Chaoyou Xue +4 more
doaj +1 more source
Cascading on extragalactic background light
, 2007 High-energy gamma-rays propagating in the intergalactic medium can interact with background infrared photons to produce e+e- pairs, resulting in the absorption of the intrinsic gamma-ray spectrum.
Aharonian +23 more
core +3 more sources
Development of a Cascade of Care for responding to the opioid epidemic
The American Journal of Drug and Alcohol Abuse, 2019 Amid worsening opioid overdose death rates, the nation continues to face a persistent addiction treatment gap limiting access to quality care for opioid use disorder (OUD).
A. Williams +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source