Results 71 to 80 of about 2,484,675 (313)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

User behaviour-driven group formation through case-based reasoning and clustering [PDF]

, 2012
Group formation for collaborative learning activities is a complex and time consuming task. Different criteria have been proposed for grouping learners in computer-based systems, such as performance and social characteristics. User behaviour is, however,
Cocea, Mihaela, Magoulas, G., Magoulas, George D.   +2 more
core   +1 more source

Using Case-Based Learning to Facilitate Clinical Reasoning Across Practice Courses in an Occupational Therapy Curriculum

Journal of Occupational Therapy Education, 2019
Although occupational therapy educators have historically used cases as a means to prepare students for clinical practice, there is little evidence that this instructional method actually facilitates clinical reasoning.
Lynne F. Murphy, Jennifer C. Radloff
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Pairwise meta-rules for better meta-learning-based algorithm ranking

, 2013
In this paper, we present a novel meta-feature generation method in the context of meta-learning, which is based on rules that compare the performance of individual base learners in a one-against-one manner.
Pfahringer, Bernhard, Sun, Quan
core   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Cased-based education rounds—the eternal heart of an international training program

Frontiers in Pediatrics
Case-based teaching or “Morning Rounds” have been used in medical education for more than a century and remain a cornerstone for teaching in many training programs.
Colm R. Breatnach, Alejandro Floh, Alejandro Floh, Melanie Hamilton, Briseida Mema, Briseida Mema   +5 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

CaseBox: a Tool for Case-based Learning

, 2005
This study reports on the development and experiment of CaseBox for case-based learning. Due to many advantages of the case-based reasoning, the authors create a learning environment for both teachers and students.
L.T. Tseng, C.H. Li, H.S. Chen
core  

Adaptive modelling of users’ strategies in exploratory learning using case-based reasoning

, 2010
In exploratory learning environments, learners can use different strategies to solve a problem. To the designer or teacher, however, not all these strategies are known in advance and, even if they were, introducing them in the knowledge base would ...
Sergio Gutierrez-Santos, Gutierrez-Santos, S., Mihaela Cocea, Cocea, Mihaela, George D. Magoulas, Magoulas, G., Gutierrez-Santos, Sergio, Magoulas, George D.   +7 more
core   +1 more source