Results 61 to 70 of about 2,484,675 (313)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Designing professional learning [PDF]

, 2014
The Designing Professional Learning report provides a snapshot of the key elements involved in creating effective and engaging professional learning in a globally dispersed market.
Learning Forward
core  

Comparison of the effectiveness of case-based and lecture-based learning strategies on the moral knowledge of the nursing staff

Journal of Education and Health Promotion
BACKGROUND: Ethics education is essential for nursing students to enhance their ethical decision-making skills. Training methods such as case-based learning (CBL) can improve nurses’ moral reasoning and sensitivity.
Shiva Khaleghparast, Zahra Ghaffarinejad, Mahta Arbabi, Samaneh Karimian, Fidan Shababi, Mansoureh Ashghali Farahani   +5 more
doaj   +1 more source

Medical student attitudes and educational interventions to prevent neurophobia: a longitudinal study

BMC Medical Education, 2017
Background With an aging American population, the burden of neurologic disease is intensifying and the decline in neurology residents and practicing neurologists is leaving these patients helpless and unable to find care. ‘Neurophobia’, a chronic illness
Lisa Shiels, Pratish Majmundar, Aleksander Zywot, John Sobotka, Christine S. M. Lau, Tuula O. Jalonen   +5 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

An innovative approach of using online problem.based learning and case-based learning in teaching disaster nursing during the COVID-19 pandemic

Journal of Integrative Nursing, 2020
Objective: The objective of this study is to evaluate the learning experience effect of online problem-based learning (PBL) and case-based learning (CBL) in teaching disaster nursing.
Yin-Ji Liang, Wei-Ju Chen, Shuang Zhou, Lin Wang, Qiu-Ying Liao, Wan-Xian Lu, Chen-Li Lin   +6 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

LEARNING APPROACHES OF MEDICAL STUDENTS IN A CASE-BASED LEARNING CURRICULUM IN PRE-CLINICAL YEAR

Pakistan Armed Forces Medical Journal, 2018
Objective: To determine the learning approaches of medical students in their pre-clinical years in a case based learning curriculum. Study Design: Descriptive (Quantitative) study.
Ambreen Gul, Ahsan Altaf, Khadija Qamar, Noor- Ul Huda, Hania Liaqat   +4 more
doaj  

Supplementation: An Improved Approach to Question Based Collaborative Learning [Letter]

Advances in Medical Education and Practice, 2021
Mohammed Haris Javed-Akhtar, Hasan Ahmed, Adil Ali Department of Medicine, Imperial College London, School of Medicine, London, UKCorrespondence: Hasan AhmedDepartment of Medicine, Imperial College London, South Kensington, London SW7 2BU, UKTel +44 ...
Javed-Akhtar MH, Ahmed H, Ali A
doaj