Results 101 to 110 of about 286,988 (311)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Applying case-based reasoning technique to retaining wall selection

, 1998
Case-based reasoning (CBR) approach recalls and learns from previous cases to resolve or provide recommendations for current problems. This study presents a case-based retaining wall selection system (CASTLES) in which the case base consists of 254 ...
J. Yang, N. Yau
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A Recommender System for Educational Planning

Cybernetics and Information Technologies
Knowledge-based recommender systems have always had their privileged place among all Decision Support Systems (DSS), given their advantage on several points over other techniques.
Skittou Mustapha, Merrouchi Mohamed, Gadi Taoufiq   +2 more
doaj   +1 more source

Conversational Case-Based Reasoning [PDF]

, 2005
Case-based reasoning (CBR) is a problem solving methodology that focuses on reusing lessons obtained from previous (possibly generalized) experiences towards solving new problems (Kolodner, 1993; Aamodt & Plaza, 1994; Watson, 1999; Bergmann, 2002).
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Determination of the Action towards the Patient’s Psychological Therapy in the Post-accident Using Case-based Reasoning

IJCCS (Indonesian Journal of Computing and Cybernetics Systems), 2018
The accident that occurred to somebody will give much suffering; moreover, if the accident gives the serious injury, such as a broken bone which needs to get more seriously treatment.
Sri Mulyana, Ilham Sahputra
doaj   +1 more source

Preferences in Case-Based Reasoning

, 2016
Case-based reasoning (CBR) is a well-established problem solving paradigm that has been used in a wide range of real-world applications. Despite its great practical success, work on the theoretical foundations of CBR is still under way, and a coherent and universally applicable methodological framework is yet missing.
openaire   +3 more sources

Integration of linked open data in case-based reasoning systems

, 2010
This paper discusses the opportunities of integrating Linked Open Data (LOD) resources into Case-Based Reasoning (CBR) systems. Upon the application domain travel medicine, we will exemplify how LOD can be used to fill three out\ud of four knowledge ...
Bach, Kerstin, Sauer, Christian, Althoff, Klaus-Dieter   +2 more
core  

Integrating case-based reasoning and hypermedia documentation: an application for the diagnosis of a welding robot at Odense steel shipyard

, 1999
Reliable and effective maintenance support is a vital consideration for the management within today’s manufacturing environment. This paper discusses the development a maintenance system for the world largest robot welding facility.
McKendrick, R J, Richard M. Crowder, Auriol, E, Knudsen, T, Crowder, R, Eric Auriol, Rowe, R, Roger Rowe, Thomas Knudsen, Crowder, R M, Rob MacKendrick   +10 more
core   +1 more source