Results 111 to 120 of about 286,988 (311)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Determinants of Sovereign Ratings: A Comparison of Case-Based Reasoning and Ordered Probit Approaches [PDF]
The paper compares two alternative techniques for the modelling of the determinants of sovereign ratings, specifically, ordered probit and case-based reasoning.
Angela Y.N.Yip +2 more
core
ADAPtER: an Integrated Diagnostic System Combining Case-Based and Abductive Reasoning
, 1995 . The aim of this paper is to describe the ADAPtER system, a diagnostic architecture combining case-based reasoning with abductive reasoning and exploiting the adaptation of the solution of old episodes, in order to focus the reasoning process.
Torasso, Pietro +4 more
core +1 more source
Case Based Reasoning and TRIZ : a coupling for Innovative conception in Chemical Engineering [PDF]
, 2009 With the evolutions of the surrounding world market, researchers and engineers have to propose technical innovations. Nevertheless, Chemical Engineering community demonstrates a small interest for innovation compared to other engineering fields.
Le Lann, Jean-Marc +2 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
A Case with a View - Towards an Integration of Visual and Case-Based Reasoning in Design
, 2001 Despite the long-term effort to establish the theoretical foundations for Case-Based Reasoning (CBR) in design, it appears that additional theoretical efforts are needed in order to achieve the promise of this affinity. In this paper we argue that visual
R. Oxman, A. Heylighen
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
International Journal of Interactive Multimedia and Artificial Intelligence, 2013 Across Latin America 420 indigenous languages are spoken. Spanish is considered a second language in indigenous communities and is progressively introduced in education.
Jorge Bacca +3 more
doaj +1 more source
, 2016 This paper presents a hierarchical approach to the problems inherent in parts of real-time strategy games. The overall game is decomposed into a hierarchy of sub-problems and an architecture is created that addresses a significant number of these through
Wender, S +3 more
core +1 more source