Results 131 to 140 of about 286,988 (311)

A case-based perspective on social web search

open access: yes, 2009
Paper presented at the 8th International Conference on Case-Based Reasoning (ICCBR 2009), Seattle, USA, July 20-23Web search is the main way for millions of users to access information every day, but we continue to struggle when it comes to finding the ...
Peter Briggs   +8 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

On the role of abstraction in case-based reasoning

open access: yes, 1996
This paper addresses the role of abstraction in case-based reasoning. We develop a general framework for reusing cases at several levels of abstraction, which is particularly suited for describing and analyzing existing and designing new approaches of this kind. We argue that in synthetic tasks (e.g.
Bergmann, Ralph, Wilke, Wolfgang
openaire   +2 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Does online case-based learning foster clinical reasoning skills? A mixed-methods study

open access: yesFuture Healthcare Journal
Background: Blended learning, integrating face-to-face and virtual methods, has become essential in clinical education, enhancing student satisfaction, engagement and knowledge outcomes.
Jun Jie Lim, Bhavani Veasuvalingam
doaj   +1 more source

Analogical asides on case-based reasoning [PDF]

open access: yes, 1994
This paper explores some of the similarities and differences between cognitive models of analogy and case-based reasoning systems. I first point out a paradox in the treatment of adaptation in analogy and in case-based reasoning; a paradox which can be only resolved by expanding the role of adaptation in cognitive models of analogy.
openaire   +2 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

Emergent Relations Self-Indexing Media for Case-Based Reasoning

open access: yes, 2003
A priori indexing systems for case-based reasoning are unlikely to engender interesting, let alone creative, explorations. The problem is that they assume a predetermined knowledge and conceptual structure which neglect new and emergent relations.
M. Tan
core  

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