Results 141 to 150 of about 29,109,104 (283)

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Comparison of the Evaluations of a Case-Based Reasoning Decision Support Tool by Expert Reviewers with those of End Users

Western Journal of Emergency Medicine, 2008
BACKGROUND: Decision-support tools (DST) are typically developed by computer engineers for use by clinicians. Prototype testing DSTs may be performed relatively easily by one or two clinical experts.
Walsh, Paul, Doyle, Donal, McQuillen, Kemedy K, Bigler, Joshua, Thompson, Caleb, Lin, Ed   +5 more
doaj  

A case-based reasoning framework for early detection and diagnosis of novel coronavirus. [PDF]

Inform Med Unlocked, 2020
Oyelade ON, Ezugwu AE.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Similarity measures and attribute selection for case-based reasoning in transcatheter aortic valve implantation. [PDF]

PLoS One, 2020
Feuillâtre H, Auffret V, Castro M, Lalys F, Le Breton H, Garreau M, Haigron P.   +6 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Combining visual analytics and case-based reasoning for rupture risk assessment of intracranial aneurysms. [PDF]

Int J Comput Assist Radiol Surg, 2020
Spitz L, Niemann U, Beuing O, Neyazi B, Sandalcioglu IE, Preim B, Saalfeld S.   +6 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

CogCBR: A Complete Case-Based Reasoning Framework for Wearable-Sensor-Based Gait Screening of Neurodegenerative Diseases. [PDF]

Sensors (Basel)
Liu H, Sun Y, Luo L, Li X, Zhang H.
europepmc   +1 more source