Results 121 to 130 of about 286,988 (311)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Prediksi Proses Persalinan Menggunakan Case Based Reasoning

JEPIN (Jurnal Edukasi dan Penelitian Informatika), 2016
Penelitian ini mengusulkan salah satu pendekatan dalam memprediksi proses persalinan menggunakan Case Based Reasoningr. Case Based Reasoning (CBR) merupakan suatu penalaran yang mengambil kesimpulan atau solusi dengan cara mengadopsi solusi yang sudah ...
Tursina Tursina
doaj   +1 more source

A New Strategy for Case-Based Reasoning Retrieval Using Classification Based on Association

, 2016
This paper proposes a novel strategy, Case-Based Reasoning Using Association Rules (CBRAR) to improve the performance of the Similarity base Retrieval SBR, classed frequent pattern trees FP-CAR algorithm, in order to disambiguate wrongly retrieved cases ...
Parsons, DJ, David Parsons, Meziane, F., Farid Meziane, Ahmed Aljuboori, Aljuboori, AS   +5 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Operationalizing Comprehensive Software Knowledge Reuse Based on CBR Methods

, 2022
S.89-98 : Ill., Lit.Reuse of software knowledge is a principle for improving productivity of software development and reliability of software systems. To achieve this, reuse must be done systematically.
Tautz, C., Althoff, K.-D.
core  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Retracted: Nursing Care Systematization with Case-Based Reasoning and Artificial Intelligence. [PDF]

J Healthc Eng, 2023
Healthcare Engineering JO.
europepmc   +1 more source

Web-based CBR (case-based reasoning) as a tool with the application to tooling selection

, 2006
Over the past few years, manufacturing companies have had to deal with an increasing demand for feature-rich products at low costs. The pressures exerted on their existing manufacturing processes have lead manufacturers to investigate internet-based ...
Cheng, K, Toussaint, J
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Model and Application of Web-based e-Assessment With Combination of Rule Base Reasoning (RBR) and Case Base Reasoning (CBR) Methods [PDF]

, 2012
E-Assessment or known as the Computer Based Assessment, Computer-Based Testing, or the Computerized Testing is a method in the management of the test with a response that was recorded electronically.
Migunani , -
core