Results 81 to 90 of about 29,109,104 (283)
Mining competent case bases for case-based reasoning
Artificial Intelligence, 2007 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Rong Pan +2 more
openaire +3 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Conversational Case-Based Reasoning [PDF]
, 2005 Case-based reasoning (CBR) is a problem solving methodology that focuses on reusing lessons obtained from previous (possibly generalized) experiences towards solving new problems (Kolodner, 1993; Aamodt & Plaza, 1994; Watson, 1999; Bergmann, 2002).
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Case-Based Reasoning Integrations.
AI Mag., 2002 This article presents an overview and survey of current work in case-based reasoning (CBR) integrations. There has been a recent upsurge in the integration of CBR with other reasoning modalities and computing paradigms, especially rule-based reasoning (RBR) and constraint-satisfaction problem (CSP) solving.
Marling, C +4 more
openaire +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
A Case-Based Classification of Respiratory Sinus Arrhythmia
, 2004 Respiratory Sinus Arrhythmia has until now been analysed manually by reviewing long time series of heart rate measurements. Patterns are identified in the analysis of the measurements.
Funk, Peter, +3 more
core +1 more source
IJCCS (Indonesian Journal of Computing and Cybernetics Systems), 2018 The accident that occurred to somebody will give much suffering; moreover, if the accident gives the serious injury, such as a broken bone which needs to get more seriously treatment.
Sri Mulyana, Ilham Sahputra
doaj +1 more source