Results 161 to 170 of about 43,177 (231)

Retinoic Acid‐Related Orphan Nuclear Receptor Alpha Promotes Cartilage Degeneration in Osteoarthritis by Activating the Wnt/β‐Catenin Pathway

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
During the development of OA, elevated RORα in chondrocytes inhibits β‐catenin degradation in the cytoplasm by activating the Wnt/β‐catenin signaling pathway. When β‐catenin protein accumulates excessively in the cytoplasm, it is transferred to the nucleus and binds to the cytosolic TCF/LEF transcriptional complex, which activates downstream target ...
Ruijue Zhu, Tianwei He, Jiawei Di, Lang Mai, Depeng Wu, Mudan Huang, Yankui Liu, Zhongyu Liu, Liangming Zhang, Lei He   +9 more
wiley   +1 more source

Proto-oncogene FAM83A contributes to casein kinase 1-mediated mitochondrial maintenance and white adipocyte differentiation. [PDF]

J Biol Chem, 2022
Huang K, Jia Z, Li H, Peng Y, Chen X, Luo N, Song T, Wang Y, Shi X, Kuang S, Yang G.   +10 more
europepmc   +1 more source

Casein kinase 1 regulates connexin-43 gap junction assembly

, 2002
Phosphorylation of members of the connexin family of gap junction proteins has been correlated with gap junction assembly, but the mechanisms involved remain unclear.
Cooper, Cynthia D, Lampe, Paul D
core   +1 more source

Fusarium oxysporum Casein Kinase 1, a Negative Regulator of the Plasma Membrane H⁺-ATPase Pma1, Is Required for Development and Pathogenicity. [PDF]

J Fungi (Basel), 2022
Mariscal M, Miguel-Rojas C, Hera C, Fernandes TR, Di Pietro A.   +4 more
europepmc   +1 more source

The conserved C-terminal residues of FAM83H are required for the recruitment of casein kinase 1 to the keratin cytoskeleton. [PDF]

Sci Rep, 2022
Kuga T, Inoue N, Sometani K, Murataka S, Saraya M, Sugita R, Mikami T, Takeda Y, Taniguchi M, Nishida K, Yamagishi N.   +10 more
europepmc   +1 more source

Clinical efficacy and safety of umbralisib, a dual PI3Kδ/CK1-ϵ inhibitor, in treatment of hematologic malignancies

Frontiers in Oncology
BackgroundUmbralisib, a dual PI3Kδ/CK-1ϵ inhibitor, has shown clinical activity in various hematologic malignancies. However, a systematic assessment of its efficacy and safety is still lacking.
Yunke Zang, Hai-en Cheng, Yanhua Sun, Jingfei Wang, Yuying Zhao, Jingning Yang, Yongping Liu, Yongping Liu, Yanli Sun   +8 more
doaj   +1 more source

Role of casein kinase 1 in the amoeboid migration of B-cell leukemic and lymphoma cells: A quantitative live imaging in the confined environment. [PDF]

Front Cell Dev Biol, 2022
Čada Š, Vondálová Blanářová O, Gömoryová K, Mikulová A, Bačovská P, Zezula N, Kumari Jadaun A, Janovská P, Plešingerová H, Bryja V.   +9 more
europepmc   +1 more source

Host casein kinase 1-mediated phosphorylation modulates phase separation of a rhabdovirus phosphoprotein and virus infection. [PDF]

Elife, 2022
Fang XD, Gao Q, Zang Y, Qiao JH, Gao DM, Xu WY, Wang Y, Li D, Wang XB.   +8 more
europepmc   +1 more source

Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling. [PDF]

J Biol Chem, 2022
Agajanian MJ, Potjewyd FM, Bowman BM, Solomon S, LaPak KM, Bhatt DP, Smith JL, Goldfarb D, Axtman AD, Major MB.   +9 more
europepmc   +1 more source

Casein kinase 1 and disordered clock proteins form functionally equivalent, phospho-based circadian modules in fungi and mammals. [PDF]

Proc Natl Acad Sci U S A, 2022
Marzoll D, Serrano FE, Shostak A, Schunke C, Diernfellner ACR, Brunner M.   +5 more
europepmc   +1 more source