The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis [PDF]
Frontiers in Oncology, 2014 Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play major regulatory roles in many cellular processes including DNA-processing and repair, proliferation, cytoskeleton dynamics, vesicular trafficking, apoptosis, and cell
Uwe Knippschild +2 more
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Casein kinase I isoforms contribute to platelet activation and thrombogenesis via RIPK3–MLKL signaling [PDF]
Communications BiologyPlatelets are small, enucleate blood cells having life span of 10-12 days that play fundamental role in hemostasis and thrombosis. Casein Kinase 1 (CK1) is a serine/threonine-specific protein kinase that governs multiple cellular processes including ...
Vipin Singh +3 more
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Cytokeratin-1 is essential for the detection of laminar shear stress in endothelial cells [PDF]
Animal Cells and SystemsEndothelial cells regulate diverse vascular functions by perceiving and reacting to laminar shear stress. In this study, a novel shear-sensing receptor was identified through the use of a pro-inflammatory protein, lysyl-tRNA synthetase (KARS), which is ...
Sunyoung Ahn +2 more
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A conserved chronobiological complex times C. elegans development [PDF]
The EMBO JournalThe mammalian protein PERIOD (PER) and its C. elegans orthologue LIN-42 have been proposed to constitute an evolutionary link between two distinct, circadian and developmental, timing systems. While the function of PER in animal circadian rhythms is well
Rebecca K Spangler +12 more
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Metabolomic and physiological analysis of bud differentiation in dense apple (Malus×domestica Borkh.) orchards following thinning and reshaping [PDF]
PeerJBackground In China, a majority of apple orchards were initially planted under arboriculture. The branch number increases, causing a deterioration of the canopy light conditions as the trees age.
Zehua Yang +4 more
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Targeting casein kinase 1 for cancer therapy: current strategies and future perspectives
Frontiers in Oncology, 2023 Casein Kinase 1 (CK1) is a family of serine/threonine protein kinases that play a crucial role in various cellular processes, including cell proliferation, survival, and metabolism.
Ngo Hoang Long, Sook-Jeong Lee
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Dangerous Duplicity: The Dual Functions of Casein Kinase 1 in Parasite Biology and Host Subversion
Frontiers in Cellular and Infection Microbiology, 2021 Casein Kinase 1 (CK1) family members are serine/threonine protein kinases that are involved in many biological processes and highly conserved in eukaryotes from protozoan to humans.
Najma Rachidi +2 more
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Scientific Reports, 2022 The casein kinase 1 (CK1) family of serine/threonine protein kinases is involved in diverse cellular events at discrete subcellular compartments. FAM83H acts as a scaffold protein that recruits CK1 to the keratin cytoskeleton or to the nuclear speckles ...
Takahisa Kuga +10 more
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Casein Kinase 1 and Human Disease: Insights From the Circadian Phosphoswitch
Frontiers in Molecular Biosciences, 2022 Biological systems operate in constant communication through shared components and feedback from changes in the environment. Casein kinase 1 (CK1) is a family of protein kinases that functions in diverse biological pathways and its regulation is ...
Joel C. Francisco +2 more
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Probiotic characteristics and zearalenone-removal ability of a Bacillus licheniformis strain. [PDF]
PLoS ONE, 2018 Zearalenone (ZEN) is a mycotoxin produced by Fusarium species, which is one of the main animal feed contaminants causing reproductive disorders in livestock. The aim of this study was to evaluate the probiotic characteristics and ZEN removal ability of a
Tsui-Chun Hsu +3 more
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